Transcript Slide 1
Food and Drug Interactions Khalid A. Al-Madani, MPH, DSc Consultant In Clinical Nutrition & Vice Present of Saudi Society for Food and Nutrition Medications and Food Intake Drug Complications That Alter Food Intake Medications and Food Intake (Conti.) Medication That Alter Appetite Diet-Drug Interactions and Absorption Medication Effects on Nutrient Absorption Diet-Drug Interactions and Absorption (Conti.) Drug-nutrient binding Diet-Drug Interactions and Absorption (Conti.) Altered acidity in the stomach Diet-Drug Interactions and Absorption (Conti.) Stomach Emptying Rate Diet-Drug Interactions and Metabolism An increase in enzyme activity leads to a decrease in drug concentration and effect AND A decrease in enzyme activity leads to an increase in drug concentration and effect Diet-Drug Interactions and Metabolism ( Conti.) Diet-Drug Interactions and Metabolism ( Conti.) A New Concern - Grapefruit Can cause more of a drug to be absorbed from intestine – even toxic levels May cause a drug not to work Diet-Drug Interactions and Metabolism ( Conti.) Diet-Drug Interactions and Metabolism ( Conti.) Vitamin K and Warfarin Keep intake of foods containing Vitamin K constant Vitamin K is high in spinach, kale, cauliflower, broccoli and other leafy greens Also don’t take Vitamin K supplement Diet-Drug Interactions and Excretion Medication Effects on Nutrient Excretion Diet-Drug Interactions and Excretion ( Conti.) Dietary Effects on Medication Excretion Diet-Drug Interactions and Toxicity Diet-Drug Interactions and Toxicity ( Conti.) MOA Inhibitors No beer, red wine No cheddar, brie, mozzarella cheese No beef or chicken liver, cured meats, caviar or dried fish Diet-Drug Interactions and Toxicity ( Conti.) Conclusion Clinicians often overlook or fail to recognize diet-drug interactions, yet such interactions can raise health care costs and result in serious, and sometimes fatal, complications. With hundreds of diet-drug interactions known and more to be identified in the future, health care professionals must learn to take steps to prevent them. THANK YOU FOR LISTENING