Transcript Safe Medication Use in the Older Adult PowerPoint Presentation 2013

Safe Medication Use in the
Older Adult
James W. Cooper, RPh, PhD, BCPS, CGP, FASCP,
FASHP, Emeritus Professor and Consultant
Pharmacist,College of Pharmacy UGa and Allison H.
Burfield RN, MS, PhD, Assistant Professor of Nursing,
UNC-Charlotte and Robert Wood Johnson Scholar in
Nursing, College of Health Sciences at
www.cooperconsultantpress.com 2/14
Title: Safe Medication Use in
the Older Adult
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Objectives to :1 Review medication-related
problems
2. Outline interventions that make
medications safer
3. Present guidelines for older adults and
their caregivers that should be followed
and shared with all health care providers
4. Propose a follow-up text as an option
for those who wish to know more about
encouraging safe medication use
Disclosure
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Dr. Cooper has nothing to disclose
concerning possible financial
or personal relationships with
commercial entities (or their
competitors) mentioned in this
presentation. He will mention past
relationships with medications and their
manufacturers as they arise in the
context of this presentation.
Epidemiology
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Up to one-third of hospital and one-half of
nursing home admissions of older adults are
associated with medication problems (Frisk PA,
Walchle RC, Cooper JW, J Clin Pharmacol 1975, AJHP 1977, Cons
Pharm 1987)
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Almost one-third of medications taken are not
given by pts. on drug history.pharmacistnurse teamwork increases Hx knowledge and
problem detection . Cooper JW, Walchle RC, McKercher PL.
Physician, pharmacist and nurse-conducted drug histories. Contemp
Pharm Pract 1980;3:75-78.
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Half to two-thirds of these problems are due
to drug misuse; one-third to one-half are due
to adverse drug reactions or interactions.
(ibid.)
Key Factors in Medication
Problems
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Drug misuse problems involve lack of patient
understanding of their drugs, e.g. name , how
to take and purpose of each, as well as
improper use due to pre-existing conditions,
e.g. aspirin-like drugs with a history of stomach
or intestinal irritation or ulcers.
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Adverse drug reactions are associated with
patients using too many drugs, seeing multiple
prescribers and pharmacists and not taking
personal responsibility for meds
Definitions
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Drug misuse involves non-adherence or noncompliance with prescribed medications or
improper prescribed use.
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Adverse drug reactions are an unwanted or
unintended effect of medications to include
side or toxic effects, allergic reactions and
idiosyncratic or unexpected reactions.
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Adverse drug interactions occur when two or
more drugs add to or interfere with an
intended therapeutic effect of each other.
ADR Concepts
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Up to 70-80% of adverse drug reactions
(ADRs) are preventable by attention to
patient history, cooperation between
patients, prescribers and pharmacists
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Fewer than one-tenth of ADRs are ever
reported per FDA Med Watch Estimate
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Some studies indicate that prescribers
recognize or attribute ADRs less than onefourth of the time when they occur
Leading Causes of Death and Costs
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Adverse drug reactions are between the 4th
and 6th leading cause of death in the USA
Some 44-100,000 deaths each year are
attributed to ADRs outside the nursing
home- estimates are that the LTC figure is
twice this number but predominantly
attributed to “natural causes”.
Drug misuse or non-compliance added to
the cost of ADRs leads to an estimated 7-8
billion dollars in health care expenditures
associated with medications or doubling of
the basic cost of drugs (Bootman ,Ann Int Med
1997)
Drug- Specific Questions for Patients
to Ask Health Care Providers for
High-Risk Medications:
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If you are taking NSAIDs such as ibuprofen,
naproxen, Feldene, Daypro, Lodine, Relafen etc.
on a regular basis, you may want to ask if
Aciphex, Prilosec, Prevacid, Protonix, or Nexium
will lower your risk of GI problems. All NSAIDs,
including Mobic and Celebrex may also cause
stomach,high blood pressure, heart failure or
kidney problems! You should not use NSAID
drugs for more than one to two weeks due to
heart, brain and stomach problems that can
occur with these drugs! TOPICAL NSAIDs are
safer for localized pain!!! Eg 10%
methylsalicylate (Oil of Wintergreen) analgesic
cream or 1%diclofenac (Voltaren Cream)
Celebrex ,Mobic and all fulldose NSAID Cautions
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Be sure to weigh daily when first taking any of
these drugs. Check stool color and stop the
NSAID if stools turn black or if you get
persistent nausea and heartburn after taking.
Report a 5 pound or more weight gain and
watch for fluid retention in your legs and
“puffiness” in your feet
Check your blood pressure- if >120/80 or you
are taking drugs for high blood pressure or
heart failure, please check with your nurse,
pharmacist and doctor. ASK YOUR DOCTOR
ABOUT TOPICAL NSAIDS for localized pain!
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Drug- Specific Questions for Patients
to Ask Health Care Providers for
High-Risk Medications:
DO NOT take low-dose aspirin without your
prescriber’s approval and you should also
have a GI-protecting drug (Prilosec or
Prevacid). If you are taking Celebrex or Mobic
(C or M ) you may have less risk of GI
problems but still need low-dose aspirin
protection for , heart, and brain problems as
neither one of these drugs (C or M ) thins the
blood! Never take aspirin with any NSAID,
Plavix or Coumadin unless your doctor
approved and protects your stomach from
bleeding with a drug like Prevacid or Aciphex!
NSAID Alternatives
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If you are taking NSAIDs you may ask if
acetaminophen (APAP,Tylenol) may be
safer for you, as well as glucoseamine
with or without chondroitin for your
osteoarthritis.
If you are taking weekly Fosamax or
Actonel/Atelvia or monthly Boniva- you
especially need stomach protection if
you are also taking ASA or NSAIDs,
Coumadin, Pradaxa, Eiquis, Xarelto, or
Plavix or Ticlid. Yearly Reclast for 3 to 5
years may be safer for your
gastrointestinal tract!
NSAID Alternatives (cont’d)
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If you have a history or risk of heart attack-(MI)-or stroke (CVA) your primary care provider
may recommend low-dose aspirin or prescribe
drugs like Plavix or Effience with aspirin to
protect your heart and brain. You will still need
stomach protection and should be taking Overthe-counter (OTC) Prevacid or Prilosec-but let
your Dr. know and agree to any of these
especially if you are taking Plavix .
Acetaminophen (Tylenol) taken 4 times a day
is safer for your arthritis, stomach, brain, kidney
and heart than NSAIDs, provided that you do
not consume alcohol with your Tylenol.
Fall Risk - Medication Risk
Reduction Questions
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If you/your care receiver are taking
drugs such as Mellaril, Haldol, Abilify,
Geodon, Seroquel, Risperdal, Invega.
Latuda, Saphris or Zyprexa, has your
dose been reduced in the last 6 to 12
months or a tapering trial without the
drug been attempted? Has a fall or
fracture occurred? If so, you need to
have all drugs evaluated and possibly
changed or the dose lowered to prevent
further falls!
Fall Related Questions Cont’d
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If you are taking drugs for anxiety or sleep such
as diazepam (Valium), Tranxene, Librium, Doral,
Paxipam, Xanax, Ativan, Centrax more often
than ONCE every week, ask your doctor for a
shorter-acting version such as oxazepam
(Serax) or safer drugs such as buspirone
(Buspar) or Celexa/Lexapro, Zoloft or for anxiety
and trazodone for sleep, if you are not napping
during the day nor taking caffeine in your diet.
Sleeping pill use may lead to 4 to 5 times
HIGHER mortality rate per year of use compared
to those who do not use sleeping pills..
Fall Related Questions Cont’d
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Are you taking antidepressants such as
amitryptyline (Elavil), nortriptyline or
doxepin for mood, sleep or pain ?
If so, have you fallen or had a fracture?
Are there safer , newer drugs in this
group ? (Zoloft, Cymbalta,
Effexor/Pristique, Celexa/Lexapro in the
morning,and trazodone or Remeron at
bedtime only and Prozac weekly)
Alternatives for Agitation and
harmful Behavior in older adults
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If your loved one has been diagnosed
with dementia or Alzheimer’s and been
prescribed one of the drugs on previous
slides for agitation and fallen, you may
ask your prescriber if PLAIN TYLENOL
FIRST then Razadyne, Aricept, Exelon,
Namenda, Buspar, OR low-dose
risperidone for SHORT PERIODS can
be used as a safer alternative to those
other drugs. Cooper JW JAMA & ConsPharm, 1997 and
2007 BMJ 2001 and 2003, Pharm Pract 2007
Cognitive Drugs-Razadyne
Aricept, Exelon and Namenda
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If you or your loved one are taking any of these
medications, please be sure that you let your
pharmacist or doctor know if you or your loved
one have any increased agitation, trouble
sleeping, heartburn or GI upset to diarrhea,
glaucoma, or leaking of urine-Some medications
may not work well with these drugs-keep a list of
all prescribed and OTC drugs and be sure to
show to all doctors, nurses, pharmacists and
other clinicians such as nurse practitioners and
physician assistants who care for you or your
loved one.
Decongestants should be avoided!
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If you are taking anything with Sudafed
and have high blood pressure,
dementia, diabetes, heart attack or
stroke or impaired kidney--- DO NOT
TAKE THESE DRUGs!
Some products that contain one of these
decongestants include Acitfed, Allegra-D,
Claritin-D, Afrinol-LA, and any cold or allergy
drug that ends with a D-.Even topical
decongestants (Afrin) may be dangerous!
Diabetes Drug Questions
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If you are diabetic and using insulin or oral drugs, ask your
Dr. about insulin “enhancers” such as metformin
(Glucophage),or Precose or Glyset to lower your insulin
needs.Drugs like Zyprexa, and Lithium increase your risk of
diabetes and there are safer alternatives. Be careful about
adding or avoid adding Actos or Avandia to insulin,
especially if you have heart failure as they cause fluid
retention! Actos is associated with an increased risk of
kidney cancer, so its use is discouraged!
If you are diabetic and have a history or heart attack or
stroke, you may need to take a beta blocking drug to protect
your heart and/or brain. If you get low blood sugar you may
not feel shaky or nervous-watch your fingerstick readings if
you are taking one of these drugs and are under tight control
(Cooper Diabetes Care 1998)
All diabetics should
Diabetes Care Questions have regular eye
exams, heart,
If you are diabetic you
thyroid and lipid
should have a personal
checks, as well as
device to regularly
special foot care. If
check your blood sugar
you develop chest
and have an A1c done
or leg pain, blackout
at least every 3 months
spells or loss of
to see if your sugar is
sensation in your
under control (8 or
hands or feet, tell
less). You may also
your diabetes care
need to take low-dose
provider
aspirin and a statin to
immediately!
protect your heart, brain
and circulation.
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Heart, High Blood Pressure and
Circulation Questions
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If you are taking any medication for your heart, HBP
or circulation, be sure you take your BP and pulse
on a regular basis and report to your primary care
provider (PCP) any consistent abnormal readings.please DO NOT TAKE any drugs for arthritis e.g.
ibuprofen (Advil), naproxen (Aleve) Celebrex , or
Mobic without checking with your pharmacist or
doctor-If you are taking any blood thinners such as
Coumadin or aspirin, Pradaxa, Xarelto, Plavix or
Effience you will need to have your blood checked
on a regular basis- DO NOT consume alcohol or
pain-medications without your PCP’s approval.
High Blood Pressure Meds
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If you are taking
diuretics or “water
pills”, are you having
your blood checked
for potassium?
If you are taking
Adalat CC,
Procardia XL,
Plendil, Norvasc or
Cardene you may
get some edema the
first 1-2 wks->
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Be sure to elevate
your legs two feet
above your heart for
1/2 hour each day to
relieve edema.
If you get a
headache with any
of these drugs, take
Tylenol 1/2 hr before
dose- the headache
will usually go away
after 7 to 10 days.
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HBP Meds
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If you are taking
Capoten, Vasotec,
Monopril, Prinivil,
Zestril, Univasc,
Aceon, Lotensin or
Accupril and get a
cough or edemaask your prescriber
for an alternative
drug (Cozaar,
Avapro, Diovan,
Micardis)
If you are taking
Hytrin, Cardura or
Minipres and gain 5
pounds or have
ankle edema or your
BP is not less than
120/80 when taking,
ask you doctor for
an alternative HBP
drug. There are
better drugs for
prostate problems
(eg, Flomax and
Uroxaltra)
HBP Meds
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If you are taking
Aldomet, Catapres,
Wytensin, Ismelin or
Tenex and feel sad
all the time-ask your
Dr. for another HBP
medication
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If you are taking a
drug for high blood
pressure and are
not watching your
salt intake, you may
not be getting the
best results from
your medicationask your nurse,
pharmacist, social
worker or Dr. about
foods high in salt
and alternatives
Heart failure drugs
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If your have congestive heart failure, you may
be taking drugs such as Lanoxin, Lasix or
Bumex, Capoten or Vasotec, Diovan or
Benecar, Coreg or Toprol and Aldactone or
Inspra.
Please be sure to weigh daily and watch for
any fluid weight gain of 5 pounds or morethis is of vital importance if you start on any
prescribed arthritis drug such as Celebrex ,
Mobic or even OTCs like ibuprofen (Advil) or
naproxen (Aleve)! Do not take any of these
NSAID drugs for more than several days due
to the risk of fluid retention, blood pressure
increases and worsening of heart failure.
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Cholesterol Check
If you have not had your cholesterol checked, ask
to have this test from your doctor or pharmacistIf you have chest or leg pain on walking, or
blackout spells or have had a heart attack or
stroke----->It is very important that you have your
cholesterol not only checked, but lowered with a
statin drug such as GENERIC FIRST of Lipitor,
Crestor, Pravacol, Zocor, Mevacor or Lescol if you
have any of these problems-you may also need to
be taking low-dose aspirin if your doctor
recommends this drug.Do NOT take aspirin with
Plavix, Pradaxa, Xarelto or Coumadin unless your
doctor has approved AND is doing frequent lab
Other Cholesterol Drugs
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If you are taking any
statin drug and have
muscle aches that
keep you awake,
ask your doctor for
another statin or the
combination of a
statin with a drug
that works in your
gut (eg add Zetia)
AND ADD COQ10
100mg/day if muscle
aches persist!
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If you are taking drugs
to lower triglycerides,
such as Lopid, Tricor
or Lipidil, call your
doctor if you get
persistent muscle
aches or flu-like
symptoms. Do NOT
take with a statin
unless your doctor is
carefully following your
lipids AND RENAL
FUNCTION!.
Depression Check
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Do you feel “down” for more than a
day or two at a time?
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Do you sleep too little or too much?
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Do you not enjoy things that used to
give you joy?
.
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Depression Check Cont’d
Has your appetite or weight changed much in
the last 6 months to a year?
Have you had any illnesses or loss of love ones
that keeps you sad for more than two weeks?
Do you have someone you can talk to about
these losses?
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If any two of these are bothering you,
please see your doctor or mental health
professional
Cancer Check
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Do you have any of the 7 warning signs?change in bowel or bladder habits?
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A sore that does not heal?
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Unusual bleeding or discharge?
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Thickening or lump in breast, testicle or
elsewhere?
Cancer Check Cont’d
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Indigestion or difficulty swallowing?
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Obvious change in a wart or mole?
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Nagging cough or hoarseness?
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Do you see a doctor at least yearly?-have a
female or male exam?
Men- PSA yearly?- Both Sexes need
Sigmoidoscopy every 3 to 5 yrs. After 50
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Cancer Check Cont’d
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Women- do you do a monthly breast
exam, annual mammogram and pelvic
with Pap test annually? This is critical
when taking any estrogen or progestin
product orally for more than 5 years. The
topical or vaginal hormone form as
cream or ring may be safer alternatives
than oral hormones but STOP ALL BY
60!.Both sexes-if fair-skinned, do you
have a dermatologist inspect sunaffected areas every year?
Eyes, Ears and Throat Drugs
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Have your eyes checked at least yearly?
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If you have glaucoma, be sure to check how
your drops are put in each eye and squint or
squeeze the bridge of the nose for 30
seconds after each dose
If you have dry eyes-or eye infections ask
your pharmacist for a tear substitute eye
drop (Liquifilm tears)and use daily with baby
shampoo cleansing of both eye sockets.
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Eyes, Ears and Throat Drugs
Cont’d
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Have your ears checked by someone close
to you-
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If there is any excessive wax, ask for an ear
cleansing solution ( Debrox)
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If you have stuffy nose- do not use oral
decongestants that have Sudafed or nose
sprays like Afrin if you have high blood
pressure, angina, TIAs or Hx of heart attack
or stroke
Throat and Breathing
medications
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If you have a sore throat, check for fever and
tenderness underneath your jaw- see your
doctor if both are present
If you have an ear ache-be sure to check your
throat
If you have asthma, bronchitis or emphysema,
be sure you know which drugs you need to
take to help your breathing
Also be sure you know which drugs you can
use for sudden shortness of breath
If you are over 50 and
Infections
NOT taking a high-potency
multiple vitamin such as
 If you get frequent Centrum Silver or
infections in your Stresstabs with Zinc or a
generic equivalent, please
chest or urinary
start taking one daily,
track, ask your
unless you are taking
prescriber about
Coumadin. A vitamin and
drugs that may
mineral supplement may
decrease the
frequency of these decrease your sick days
due to these infections.
infections
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Immunizations
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If you have not had a
flu shot or Pneumonia
shot, ask your
prescriber about
these shots.
If you have not had a
tetanus whooping
cough and diptheria
shot in the last 10
years, you need a
booster! ALSO ASK
about a shingles shot.
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If you have a
chronic cough and
are not a smoker,
nor live with
someone who
smokes, nor taking
drugs called ACE
inhibitors, you may
need a whooping
cough booster shot
with your tetanus
and diptheria
booster (TdpBoostrix, Adacel).
Osteoporosis
 Be sure that you are taking at least 1500 mg of
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calcium citrate per day and 800 to 1,000 units of
vitamin D-Ask your doctor, nurse or pharmacist
about drugs to preserve bone strength
You should NOT be taking hormones for
osteoporosis, but if you are taking them be sure
that you have a mammogram and female exam
at least yearly or more often.
Fosamax, Actonel, Boniva, Zometa/Reclast,
Forteo, Micalcin or Evista are the only drugs that
should be used for osteoporosis FOR NOT
MORE THAN 3 to 5 years. If you have
esophagitis, reflux heartburn or stomach ulcers,
yearly IV ONLY Reclast or Zometa may be the
only safe drug for your osteoporosis.
Oral bisphosphonates for OP
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If you are taking Fosamax or Actonel /Atelvia
weekly to bi-weekly or Boniva monthly, you
should be able to swallow a full-glass of plain
water and sit-upright for 30 minutes to an hour
after taking these drugs to prevent erosion of
your esophagus or stomach or small intestines. If
you are taking any drugs for reflux, GERD or
stomach problems you may not be able to take
any of the above oral drugs- ask your doctor
about a yearly to biyearly infusion of Reclast for
3 to 5 years at most, or Forteo daily injections for
no more than 6 months. YOU MUST TAKE
ADEQUATE CALCIUM AND VITAMIN D FOR
ANY OF THESE DRUGS TO WORK!
Hormones for Osteoporosis or
Perimenopausal Symptoms
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The oral pills like  Ask your doctor about the
topical patch (Climara,
Premarin and
Estrace should not Vivelle, Combipatch)
be taken for more creams (Premarin) or
than one year after intravaginal ring (Nuvaring)
menopause due to a that may be safer for your
breasts and uterus than the
greatly increased
pill AND SOME PATCHES
risk of breast and
uterine cancer, heart forms for ONE YEAR OR to
age 60- then NO
attacks, stroke,
ESTROGEN!.(Manson JE,et al.
diabetes and
NEJM 2001;345:34-40; Gennazzani AD
dementia.
et al Fert Steril 2001;76:241-8)
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Hormone Myths
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Estrogen and progestin
do NOT protect against
cardiovascular (CV)
disease-peri and
postmenopausal women
need statin therapy for
high lipids, not
hormones. Hormones
actually increase risk of
clots, heart attack,
diabetes, dementia and
stroke !
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Estrogen and
progestin do NOT
protect against
memory loss they
actually INCREASE
risk of Alzheimers
dementia.
Estrogen can be
safely used at any
age is FALSE-all
women should stop
oral hormone
replacement therapy
by one year after
menopause. Never
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Hormone Precautions!
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Be sure that if you
are taking any
estrogen product
and still have your
uterus that you ask
your prescriber
about progestin
therapy to protect
your uterus from
cancer caused by
unopposed
estrogen!
Any sex hormone
replacement
therapy, pill, patch,
cream or vaginal
ring requires that the
woman do a
monthly breast selfexam, and have at
least an annual
pelvic exam and
Pap smear. If you
Dr. does not want to
do this-get another
Dr.!
Other Hormones
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If you are taking thyroid, ask to have your
tests checked yearly- if you did not have
blood work before your thyroid was
prescribed, ask for blood work after thyroid
has been stopped for 4 to 6 weeks

If you are taking cortisone-like medications
such as prednisone by mouth or into your
lungs as an inhalation, ask about bone and
stomach protection

Do not take ANY alternative or herbal
medications without medical advice and
approval!
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Urinary Incontinence

Many older adults
have some
incontinence, from
occasional to frequent
leaking of urine. If you
or you loved one has
this problem, please
seek advice on
management of this
problem from your
health care providers
Incontinence can
lead to dehydration,
chronic constipation,
and more frequent
lung and urinary
tract infections as
well as falls. Some
drugs can help and
some drugs can
cause incontinenceplease ask your
pharmacist to look
at your drug list if
you develop leaking
urine.
Wellness Medication Checklist
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If you are not taking a multiple vitamin and
mineral supplement, consider or ask for a
recommendation to decrease sick days due to
infections
What is your support system- church,
synagogue, temple ,mosque, friends, and
loved ones?
Is your diet adequate? Are you able to exercise
daily?
Do you have someone to talk with about things
that bother you?
Do you have a doctor and pharmacist who know
all your medications?
Summary and Conclusions

In the year elderly become progressively to
severely disabled a large proportion are
hospitalized for a small number of diagnoses,
most of which relate to drug use. (Ferruci L, et al JAMA
1997;277:728-34)

Adverse Drug Rxns (ADRs) are only 1/3 of
drug-related admissions; other 2/3 are related
to nonadherence to prescribed treatment (Frisk
PA, Walchle RC ,Cooper JW, et al. AJHP 1977; 34:738-42)
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How can health care practitioners and
caregivers improve drug use among older
adults?
How can patients decrease
medication problems?

Keep a personal record of all drugs prescribed
or self-treated, and avoid alternative
treatments or supplements unless they are
approved by a primary care provider physician
or pharmacist. (personal drug checklist)

Show this medication record to every health
care provider utilized- e.g. doctors, dentists,
podiatrists, nurses, pharmacists etc.

Expect each health care provider to review all
current drugs and problems before adding
another drug.
Consumer Responsibilities And
Rights Concerning Medications

Patient “Bill of Rights” considers that
each patient will have the right drug in
the right dose for the right period of
time for the right indication

The patient can expect that they will
have minimal risk of adverse drug
reactions
Consumer Responsibilities And
Rights Concerning Medications

Cont’d
Patients should be able to give the name of each
drug, how to use the drug and what to expect
from the drug in order to best use the drug in
their overall treatment scheme-Patients should
expect reasonable medication outcomes! If you
want to present these slides, e-mail me at
[email protected] for free copy. Dr. Jack
Fincham’s superb book “Taking Your Medicine” is
highly recommended for the caregiver and
layperson who wants to better understand their
medications and may be ordered via
www.takingyourmedicine.com. Or by sending $20
to Jack Fincham, PhD, RPh, 7311 W. 145
Terrace, Overland Park KS, 66223.