Transcript Molecular Immunology

Molecular Immunology
Saverio Minucci
General informations
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PPT slides
– home page: http://users.unimi.it/minucci/index.htm
– Click on “didattica” :
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http://users.unimi.it/minucci/didattica.htm
– Anche su ARIEL
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Exams:
– team presentation of one paper related to the topics discussed during the lessons
– 1 written test at the end of the course (open essay: 1 topic of your choice, 1 topic chosen by
me)
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Official books: none
– Abbas/Lichtman (Basic Immunology- or italian translation)
– Pier/Lyczak/Wetzler (Immunology, infection and immunity –or italian translation)
– Whatever…
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X info:
– [email protected]
– [email protected]
Examination dates
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- 25 gennaio 12.00-14.00 aula da definire
- 08 febbraio 12.00-14.00 aula da definire
- 22 febbraio 12.00-14.00 aula da definire
- 15 giugno 12.00-14.00 aula da definire
- 28 giugno 12.00-14.00 aula da definire
- 12 luglio 12.00-14.00 aula da definire
- 30 settembre 12.00-14.00 aula da definire
A few questions for you…
• What’s the difference between innate and
adaptive immunity?
– What can you say about innate immunity
• Describe phagocytosis
– How is the phagocyte attracted by its target?
• How many types of adaptive immune
responses do you know?
• Can you give me one example of passive
immunity?
Let’s define together
the cardinal features of
adaptive immune responses
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Specificity
Diversity
Memory
Non reactivity to self
Adaptive immune response
• What is a “naïve” T (or B) cell?
• How is it that immune cells are able to avoid
killing “self” cells?
• Activated immune cell becomes either
an…….or a ……….cell
• What is the difference between a CD4+ and a
CD8+ cell?
• Which is the cell that is the main producer of
antibodies?
Lymphocytes
• What’s the CD nomenclature?
• What is the main difference among B and T
lymphocytes?
• Which are the main classes of effector T
lymphocytes?
• What is an APC? What’s the name of the most
important class of APCs?
Phases of adaptive response
• Antigen recognition
• Lymphocyte activation
• Effector Phase
Response to infective agents:
an example
Topics to be addressed in the course
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Vaccines
Autoimmune diseases
Allergy
Immunological reactions against tumors
Transplantation
AIDS and Kaposi sarcoma