Transcript Overview of the Immune System

Overview of the Immune
System
A Historical perspective
First Historical reference
Thucydides, first
refers to immunity
describing a
plaque in Athens
(430 BC)
Variolation
Crude attempts at
immunization were
made in the fifth
century by the
Chinese and the Turks
Edward Jenner (1798)
Louis Pasteur
Proved that Vaccination
works
Used Dubious means to
conduct his experiment
Father of Microbiology
Found vaccines for both
Rabies and Anthrax a
scourge of the nineteenth
century
Emil von Behring and Shibasaburo Kitsato (1890)
provided the first insights into the mechaniism of
immunity.
They demonstrated that SERUM (THE
NONCELLULAR PORTION OF BLOOD) could transfer
the immune state to unimmunized host.
This component could
neutralize toxins,
precipitate toxins, rupture
(lyse) bacteria and
agglutinate bacteria
Antibody
Phagocytes: White Blood Cells
Cell Mediated Immunity
Humoral and Cell
mediated Immunity
were both shown to
be necessary for the
immune response
Paul Ehrlich (1900)
Clone Wars?
Anatomical Barriers: Skin
Skin
Mucous Membrane
Sebum: Sebaceous Glands
Cilia
Lysozyme
Interferon
Endocytosis
Phagocytosis
Pinocytosis: Cell Mediated
Endocytosis
Endosomes: