Transcript Supplements vs Inflammation

Angelita B. Frando, MD
Board Certified in Family Medicine
Board Certified , American Academy of Medical Acupuncture
Board Certified, American Academy of Anti-Aging and Regenerative Medicine
Definition:
 complex biological response to harmful stimuli
(pathogens, damaged cells or irritants)
 Protective attempt to remove the injurious stimuli and
initiate the healing process
 Important for survival
Definition:
 Causes wounds and infections to heal (acute)
 Chronic = progressive destruction of tissue =>disease
and degenerative changes
Manifestations (Signs):
 Calor (Heat)
 Rubor (Redness)
 Tumore (Swelling)
 Dolor (Pain)
 Functio laesa (loss of function)
Causes:
 Burns
 Chemical irritants
 Frostbite
 Toxins
 Infection by pathogens
 Physical injury, blunt or penetrating
 Immune reactions due to hypersensitivity
 Ionizing radiation
 Foreign bodies (ie., splinters, dirt and debris)
 Stress
 Trauma
 Alcohol
Physical Injury,
Trauma
Burns
Infectious:
Bacteria,
Viruses,
Parasites
Immune
Reactions
(Hypersensitivity)
Ionizing
Radiation
Inflammation
Toxins
Foreign bodies
(ie., splinters,
dirt, debris)
Chemical
irritants
Frostbite
Alcohol
Stress
Types: Acute & Chronic
 Names Based on body system / organ involved:
(“-itis”)
 Appendicitis (Appendix)
 Arthritis (Bone)
 Bursitis (Bursa)
 Cholecystitis (Gallbladder)
 Colitis (Colon)
Types: Acute & Chronic
 Names Based on body systems / organs involved:
 Cystitis (Urinary Bladder)
 Dermatitis (Skin)
 Epiglotitis (Epiglotis)
 Esophagitis (Esophagus)
 Duodenitis (Duodenum)
 Gastritis (Stomach)
 Hepatitis (Liver)
 Parotitis (Parotid Gland)
 Pancreatitis (Pancreas)
Types: Acute & Chronic
 Names Based on body systems / organs involved:
 Myositis (Muscles)
 Meningitis (Meninges of brain)
 Pneumonitis / Bronchitis (Lungs)
 Rhinitis (Nose)
 Tendonitis (Tendons)
 Tonsillitis (Tonsils)
 Vasculitis (Blood vessels)
Acute vs Chronic
Acute:
Chronic:
 Bacteria, injured tissues
 Persistent acute
 Immediate onset
inflammation, viruses,
persistent foreign bodies,
autoimmune reactions
 Delayed Onset
 Up to many months or years
 Outcome:
 Duration: Few days
 Outcome:
 Resolution, abscess, or
chronic inflammation
 Tissue destruction, fibrosis,
necrosis
Process of Acute Inflammation:
 Injury/pathogen => cells activated to release
inflammatory mediators:
Process of Acute Inflammation:
 Vasodilatation => Increased blood flow => redness and
heat
Process of Acute Inflammation:
 Increased blood vessel permeability => leakage of
plasma proteins and fluid into tissues (swelling)
Process of Acute Inflammation:
 Some mediators increase sensitivity to pain
 Other biochemical reactions occur (complement
system, coagulation and fibrinolysis systems, etc.)
Cell derived mediators:
 Lysosome granules
 Histamine
 Interferon (cytokines)
 IL-8 (Interleukin 8)
 Leukotriene B4
 Nitric oxide
 Prostaglandins
 TNF-alpha and IL-1
Inflammatory Markers:
 CRP (C-reactive protein)
 Increased levels associated with increased risk of heart
attacks, strokes, high blood pressure, muscle weakness
and fragility
 ESR (erythrocyte sedimentation rate)
 Homocysteine levels
 Tumor necrosis factor –alpha (TNF-@)
 Interleukin 6, 8, 18 (IL-6, IL-8, IL18)
 Blood glucose, insulin and leptin (especially for obese)
Disorders associated with Inflammation:
 Acne vulgaris
 Allergies
 Asthma
 Atherosclerosis
 Autoimmune disease
 Cancer
 Celiac disease
 Chronic prostatitis
Disorders associated with Inflammation:
 Costochondritis
 Degenerative arthritis,
 Hypersensitivities
 Interstitial cystitis
 Inflammatory bowel / Digestive tract disordes
(Pancreatitis, Crohn’s disease, Regional enteritis,
Enteropathies, Hepatitis, etc.)
 Kidney diseases (Diabetic Nephropathy,
Glomerulonephritis, etc)
 Myopathies
Disorders associated with Inflammation:
 Obesity
 Osteoporosis
 Pelvic inflammatory disease
 Reperfusion injury
 Rheumatoid arthritis , Lupus, and other connective tissue




disorders
Skin: Psoriasis, Dermatitis
Sarcoidosis
Transplant rejection
Vasculitis
Medications vs Inflammation
 Aspirin
 Works on prostaglandins

Watch for gastrointestinal ulcers and bleeding
 NSAIDS


May cause gastric/duodenal ulcers
May damage kidneys with prolonged use
 Cox-2 inhibitors
 Steroids:
 Problems with acute use:

Weight gain, Irritability, steroid psychosis, acne
 Problems with prolonged use
 Weight gain, metabolic syndrome, gastric ulcers, blunts adrenal
function, etc.
Supplements vs
Inflammation
Benefits of OPCs
 Anti-inflammatory properties
 Helps decrease asthma attacks
 Helps reduce mild menstrual cramping and abdominal
pain
 Helps maintain joint flexibility
 Promotes healthy Cox2 activity
 Decrease allergic response
 Reduce histamine production and prevent formation
(inflammatory chemicals)
 Promotes normal immune function
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Scientific Studies:
 Improvement in Circulation and in Cardiovascular Risk
Factors with a Proprietary Isotonic Bioflavonoid Formula
OPC3
 Maria R. Cesarone, MD, Andrea Di renzo, Silvia Errichi, MD, Frank Schonlau, PhD, James
L. Wilmer, PhD, and Julian Blumenfeld, MD; Angiology, Volume 59; Number 4;
August/September 2008, 408-414
 Subjects were supplemented with OPC3 or placebo over 2 months.
Plasma oxidative stress status was significantly lowered by 10.1% with
OPC3. OPC3 significantly improved endothelial function. Cardiac
ultrasound revealed a significant increase of left ventricular ejection
fraction. Blood pressure, total cholesterol and fasting blood glucose
were lowered. Skin microcirculation was enhanced and better tissue
perfusion led to increased oxygen pressure and decreased p CO2. A
dramatic and significant plasma C-reactive protein decrease by 52.1%
occurred.
Omega III Benefits
 Anti-inflammatory:
 Promotes healthy levels of C-reactive protein
 Promotes joint health (vs arthritis)
 Supports retinal health
 Promotes a healthy complexion
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Digestive Enzymes:
 Benefits:
 Aids in digestion of proteins, fats and carbohydrates
 Supports nutrient absorption (good for malabsorption,
in children, elderly, poor digestion, etc.)
 May help ease stomach upset
 Probiotics promote normal intestinal flora (helps for
acute gastroenteritis, diarrhea, etc.)
 Supports healthy immune function
Supplements vs Inflammation
 Arthritis:
 OPC3
 Omega 3
 Glucosatrin (Boswellia with Cox-2 inhibition)
Supplements vs Inflammation
 Acne vulgaris:
 Oxygen extreme
 Digestive enzymes
Supplements vs Inflammation
 Asthma/ Allergies:
 OPC3
 Aloe Juice
 ORAC
 Omega 3
 Curcumin
Supplements vs Inflammation
 Atherosclerosis
 OPC3
 Heart Health
 Omega 3
 Activated Vitamin B
 Resveratrol
Supplements vs Inflammation
 Autoimmune diseases:
 OPC3
 Omega 3
 Resveratrol (do not give with Coumadin or breast
cancer)
 Curcumin
 Co-Q-10
 Vitamin B, activated
 Multivitamins/Minerals
Supplements vs Inflammation
 Cancer
 During remissions

Breast Cancer
 B complex
 Vitamin D3
 Calcium
 CoQ-10
 OPC3
 Multivitamins/multiminerals
Supplements vs Inflammation
 Cancer
 During remissions (not during treatment)

Colon Cancer
 Resveratrol
 Fiber powder
 B complex
 CoQ-10
 OPC3
 Vitamin D3
 Multivitamins/multiminerals
Supplements vs Inflammation
 Celiac disease
 Digestive enzymes
 Aloe
 Probiotics
 Fiber powder (prebiotics)
Supplements vs Inflammation
 Inflammatory GI/bowel disorders, etc.
 Crohn’s disease – OPC3, Digestive enzymes, Aloe
 Irritable Bowel Syndrome – OPC3, Aloe, Digestive
enzymes
 Diverticulitis – (after bowel rest and antibiotics) Aloe,
Digestive enzymes, fiber powder (for diverticulosis),
OPC3
 Pancreatitis – Digestive enzymes
 Gastric / Duodenal Ulcer – Aloe, Digestive enzymes
 Hepatitis – Digestive enzymes, Hepatocleanse
Supplements vs Inflammation
 Inflammatory GI/bowel disorders, etc.
 Crohn’s disease :






OPC3
Digestive enzymes
Aloe
Probiotics
Vitamin D3
Vitamin B12, Folic acid
Supplements vs Inflammation
 Inflammatory GI/bowel disorders, etc.
 Irritable Bowel Syndrome:




OPC3
Aloe
Digestive enzymes
Probiotics
Supplements vs Inflammation
 Inflammatory GI/bowel disorders, etc.
 Diverticulitis : (after bowel rest and antibiotics)





Aloe
Digestive enzymes
Fiber powder (for diverticulosis)
OPC3
Probiotics
Supplements vs Inflammation
 Inflammatory GI/bowel disorders, etc.
 Pancreatitis :


Digestive enzymes
If alcoholic: Vitamin B complex
Supplements vs Inflammation
 Inflammatory GI/bowel disorders, etc.
 Gastric / Duodenal Ulcer:



Aloe
Digestive enzymes
Calcium
Supplements vs Inflammation
 Inflammatory GI/bowel disorders, etc.
 Hepatitis:


Digestive enzymes
Hepatocleanse
Supplements vs Inflammation
 Degenerative arthritis:
 Omega 3
 OPC3
 Glucosatrin
 Prime Joint Health
 Calcium (osteoporosis)
Supplements vs Inflammation
 Kidney disease due to diabetes :
 OPC3 (if potassium is normal)
 Interstitial cystitis
 OPC3
 ORAC
 Bliss
 ACTS

If thyroid normal or hypothyroid
Supplements vs Inflammation
 Osteoporosis:
 Calcium plus
 Vitamin D3 with K2 (IF Vitamin D deficient)


D3 levels should be optimally placed at around 40-60 nmol/l
Monitor blood levels to avoid toxicity
Supplements vs Inflammation
 Gout:
 OPC3
 Curcumin
 ORAC
 Aloe
Supplements vs Inflammation
 OBESITY:
 Associated with chronic inflammation

Waist circumference correlates to inflammatory response
 OPC3
 Resveratrol
 Omega 3
 Transitions :

ACTS
Supplements vs Inflammation
 Reperfusion Injury (Brain):
 Post-Stroke




OPC3
Resveratrol
Omega 3
B complex
Supplements vs Inflammation
 Reperfusion Injury (Heart):
 Post- Myocardial infarction




OPC3
Resveratrol
Omega 3
B complex
Supplements vs Inflammation
 Eczema:
 OPC3
 Omega 3
 Psoriasis:
 OPC3
 Hepatocleanse / 7 day detoxification
 Curcumin
Keep Inflammation in moderation