INFLAMMATION and YOUR HEALTH
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Transcript INFLAMMATION and YOUR HEALTH
Angelita B. Frando, MD
Board Certified in Family Medicine
Board Certified , Medical Acupuncture
Definition:
complex biological response to harmful stimuli
(pathogens, damaged cells or irritants)
Protective attempt to remove the injurious stimuli and
initiate the healing process
Important for survival
Causes wounds and infections to heal (acute)
Chronic = progressive destruction of tissue =>disease
and degenerative changes
Manifestations (Signs):
Calor (Heat)
Rubor (Redness)
Tumore (Swelling)
Dolor (Pain)
Functio laesa (loss of function)
Causes:
Burns
Chemical irritants
Frostbite
Toxins
Infection by pathogens
Physical injury, blunt or penetrating
Immune reactions due to hypersensitivity
Ionizing radiation
Foreign bodies (ie., splinters, dirt and debris)
Stress
Trauma
Alcohol
Types: Acute & Chronic
Names Based on body systems / organs involved: ( “-itis”)
Appendicitis
Arthritis
Bursitis
Colitis
Cystitis
Dermatitis
Myositis
Meningitis
Tendonitis
Tonsillitis
Vasculitis
Acute vs Chronic
Causative agent:
Bacteria, injured tissues
Persistent acute
Immediate onset
inflammation, viruses,
persistent foreign bodies,
autoimmune reactions
Delayed Onset
Up to many months or years
Outcome:
Duration: Few days
Outcome:
Resolution, abscess, or
chronic inflammation
Tissue destruction, fibrosis,
necrosis
Process of Acute Inflammation:
Injury/pathogen => cells activated to release
inflammatory mediators:
Vasodilatation => Increased blood flow => redness and
heat
Increased blood vessel permeability => leakage of
plasma proteins and fluid into tissues (swelling)
Some mediators increase sensitivity to pain
Other biochemical reactions occur (complement
system, coagulation and fibrinolysis systems, etc.)
Cell derived mediators:
Lysosome granules
Histamine
Interferon (cytokines)
IL-8 (Interleukin 8)
Leukotriene B4
Nitric oxide
Prostaglandins
TNF-alphaand IL-1
Inflammatory Markers:
CRP (C-reactive protein)
Increased levels associated with increased risk of heart
attacks, strokes, high blood pressure, muscle weakness
and fragility
ESR (erythrocyte sedimentation rate)
Homocysteine levels
Tumor necrosis factor –alpha (TNF-@)
Interleukin 6, 8, 18 (IL-6, IL-8, IL18)
Blood glucose, insulin and leptin (especially for obese)
Disorders associated with Inflammation:
Acne vulgaris
Allergies
Asthma
Atherosclerosis
Autoimmune disease
Cancer
Celiac disease
Chronic prostatitis
Degenerative arthritis,
Hypersensitivities
Interstitial cystitis
Inflammatory bowel / Digestive tract disordes (Pancreatitis, Crohn’s disease, Regional enteritis, Enteropathies, Hepatitis, etc.)
Kidney diseases (Diabetic Nephropathy, Glomerulonephritis, etc)
Myopathies
Obesity
Osteoporosis
Pelvic inflammatory disease
Reperfusion injury
Rheumatoid arthritis , Lupus, and other connective tissue disorders
Skin: Psoriasis, Dermatitis
Sarcoidosis
Transplant rejection
Vasculitis
Medications vs Inflammation
Aspirin
Works on prostaglandins
Watch for gastrointestinal ulcers and bleeding
NSAIDS
May cause gastric/duodenal ulcers
May damage kidneys with prolonged use
Cox-2 inhibitors
Steroids:
Problems with prolonged use
Weight gain, metabolic syndrome, gastric ulcers, blunts
adrenal function, etc.
Supplements vs Inflammation
Arthritis:
OPC3
Omega 3
Glucosatrin (Boswellia with Cox-2 inhibition)
Supplements vs Inflammation
Acne vulgaris:
Prevaderm
Digestive enzymes
Supplements vs Inflammation
Asthma/ Allergies:
OPC3
Aloe
ORAC
Supplements vs Inflammation
Atherosclerosis
OPC3
Heart Health
Omega 3
Activated Vitamin B
Resveratrol
Supplements vs Inflammation
Autoimmune diseases:
OPC3
Omega 3
Resveratrol (do not give with Coumadin or breast
cancer)
Co-Q-10
Vitamin B
Multivitamins/Minerals
Supplements vs Inflammation
Cancer
During remissions
Breast Cancer
B complex
Vitamin D3
Calcium
CoQ-10
OPC3
Multivitamins/multiminerals
Supplements vs Inflammation
Cancer
During remissions (not during treatment)
Colon Cancer
Resveratrol
Fiber powder
B complex
CoQ-10
OPC3
Multivitamins/multiminerals
Supplements vs Inflammation
Celiac disease
Digestive enzymes
Aloe
Supplements vs Inflammation
Degenerative arthritis:
Omega 3
OPC3
Glucosatrin
Supplements vs Inflammation
Inflammatory GI/bowel disorders, etc.
Crohn’s disease – OPC3, Digestive enzymes, Aloe
Irritable Bowel Syndrome – OPC3, Aloe, Digestive
enzymes
Diverticulitis – (after bowel rest and antibiotics) Aloe,
Digestive enzymes, fiber powder (for diverticulosis),
OPC3
Pancreatitis – Digestive enzymes
Gastric / Duodenal Ulcer – Aloe, Digestive enzymes
Hepatitis – Digestive enzymes, Hepatocleanse
Supplements vs Inflammation
Kidney disease due to diabetes:
OPC3
Interstitial cystitis
OPC3
Supplements vs Inflammation
Osteoporosis:
Calcium plus
Vitamin D3 with K2 (IF Vitamin D deficient)
D3 levels should be optimally placed at around 40-60 nmol/l
Monitor blood levels to avoid toxicity
Supplements vs Inflammation
OBESITY:
Associated with chronic inflammation
Waist circumference correlates to inflammatory response
OPC3
Resveratrol
Omega 3
Transitions
Supplements vs Inflammation
Reperfusion Injury (Heart and Brain):
Post- Myocardial infarction and Post-Stroke
OPC3
Resveratrol
Omega 3
Psoriasis:
OPC3
Keep Inflammation in moderation