Communication & cell signalling
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Transcript Communication & cell signalling
Communication & cell signalling
Explain the term ‘cell signalling’
Explain the role for membrane-bound receptors as
sites where hormones & drugs can bind
Cell Signalling
Cells communicate with each
other through signals
Inside the cell between
components
Outside the cell between cells
Different molecules send
different signals
To detect signals, cells must
have sensors-receptors (often
proteins)
Why do cells need to be able to communicate with each other and inside a
cell? Give a specific example for each.
4 points
Single celled organisms-detect & move towards nutrients for survival
Multicellular organisms-coordination between cells for:
o Growth
o Development
o Movement
o Excretion
Detect internal & external signals
Respond to signals and carrying out function/process
Receptors detect the signals
Hormone Receptors
Hormones=chemical messengers
transported in the blood
Cell communication is often
mediated by a hormone
Target cells-Any cell with a
receptor for a hormone
Hormone & receptor on target
cell bind due to their
complementary shapes
(JIGSAW!)
Binding causes the target cell to
respond in a certain way
Insulin
Where is insulin released from?
Beta cells in islets of Langerhans in
the pancreas
Why is it released?
In response to high glucose levels
What do you think happens when the
hormone binds to the receptor?
Internal cell response triggered
More glucose channels become
present in the membrane
Cell takes up more glucose
Reduces blood glucose levels
Medicinal Drugs: Interfering with Receptors
Beta Blockers- Block receptors & prevent the heart muscle from increasing
the heart rate
Some drugs mimic natural neurotransmitters e.g. in Schizophrenia
Hijacking receptors:
Viruses enter cells by binding with receptors on cells PM e.g. HIV
can enter cells of the immune system (T lymphocytes)
Due to shape which fits into the receptor
Prevents cells from doing its job/may destroy cell
How does Botox work?
Uses a toxin from the bacterium Clostridium Botulinum
Toxin binds with receptors on muscle fibres
Prevents them working
Causes paralysis
If done in the face, reduces wrinkling of skin