02. spare receptors
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Transcript 02. spare receptors
SPARE RECEPTORS
DR. SHABANA ALI
SPARE RECEPTORS
Total number of receptors present compared
with the number actually needed to elicit a
max. biological response
A
pharmacological system has spare
receptors if a full agonist can cause a max.
response when occupying only a fraction of
total receptor population
Cont.
Diverse molecular mechanisms responsible
for spare receptor
Partial agonists can become full agonist if a
receptor reserve exist
Spare receptor increase sensitivity t o drug
If EC50 < Kd, spare receptors exist