Transcript b-cells - APBiology2015-2016

B-CELLS
Rachel Gluski, Vickie Le, Lena
Wachs
https://courses.candelalearning.com/anatomyphysiology2/chapter/21
-4-the-adaptive-immune-response-b-lymphocytes-and-antibodies/
What are B-cells?
• B-Cells belong to the variety of white blood cells and play a role
in the immune system by making y-shaped proteins called
antibodies.
• They are found in the bone marrow where stem cells develop
them.
• They are also known as B lymphocytes.
http://www.clker.com/clipart-naive-b-cell.html
http://www.bdbiosciences.com/sg/research/bcell/
B-Cell Receptor
• The B-cell receptor’s(BCR) role is to specifically bind
intact antigens on the surface of invasive bacteria or
viruses.
• It can be found exposed at the cell surface in thousands
and as soluble molecules in the extracellular fluid.
Signaling (reception)
• B-cells bind intact antigens through receptor-mediated
endocytosis, causing the antigen to be digested into
fragments.
• The ligand is the antigen (Signal)
• The receptor is the BCR (reception)
B-cell Reception
https://askabiologist.asu.edu/b-cell
To Textbook
EXTRACELLULAR
FLUID
Receptor
Signaling
molecule
CYTOPLASM
Plasma membrane
Transduction
• The fragments will later appear on the cell
surface inside a molecule because it is now a
plasma cell.
• T-cells help b-cells function properly by
releasing chemicals that signal the b-cells to
divide in multiples and attack invaders inside
the cell that may interfere with the signal
pathway.
B-cell Transduction
https://askabiologist.asu.edu/b-cell
To Textbook
EXTRA-CELLULAR FLUID
Signaling molecule
(first messenger)
The cytoplasmic domains of Ig-alpha and
Ig-beta do not contain kinase domains but
are phosphorylated on tyrosine residues
immediately upon receptor ligation.
Various
proteins
activated
Cellular
responses
Phagocytosis
http://leavingbio.net/the%20human%20defence%20system-web2.htm
Receptor Mediated Endocytosis
Cellular Response
• The response of B-cells is the function of realeasing
antibodies
• Antibodies made by the B-cells bind to antigens on the
surface of germs and clump up. This process is called
“agglutination.”
• The accumulation of antibodies alerts your body to the
presence of intruders.
• The body then sends phagocytes to engulf and destroy
antibody-covered intruders.
B-cell Response
https://askabiologist.asu.edu/b-cell
Amplification
• One B-cell can result in many plasma cells, in
turn resulting in even more antibodies being
released
Reception, Transduction, &
Response
https://askabiologist.asu.edu/b-cell
Citations
• Campbell, Neil A., and Jane B. Reece. Biology. New York, NY: Custom, 2008. Print.
• "B Cells and T Cells." B Cells and T Cells. N.p., 17 Aug. 2015. Web. 08 Nov. 2015.
• National Center for Biotechnology Information. U.S. National Library of Medicine, n.d.
Web. 08 Nov. 2015.
• "OpenStax CNX." OpenStax CNX. N.p., n.d. Web. 08 Nov. 2015.
• "School of Life Sciences | Ask A Biologist." B-Cells. N.p., n.d. Web. 08 Nov. 2015.