Transcript CLASS REVIEW...in the form of Jeopardy!

Jeopardy!
Immunology Edition!
By: Brian Jackson, MS I
Instructions
1. Choose the category and dollar amount.
The answer will appear on your screen.
2. Once you’ve answered, click anywhere
for the correct question.
3. IMPORTANT: Click on the correct
question to return to the board!
4. When you’re done with a section, click
on the link at the bottom of the board to
advance.
“IL”
Wind
Be
Sensitive
I’m Cured
Less than
Ideal
Potpourri
Cell it!
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400 400 400 400 400 400
600 600 600 600 600 600
800 800 800 800 800 800
1000 1000 1000 1000 1000 1000
Click Here to advance to Double Jeopardy
Click here to return to the board.
Barely
Tolerated
Innate
Talents
Organs of
the Body
Develop
Yourself
Signal
Diagnosis:
Received Immunity
400 400 400 400 400 400
800 800 800 800 800 800
1200 1200 1200 1200 1200 1200
1600 1600 1600 1600 1600 1600
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Click to advance to Final Jeopardy
Click here to return to the board.
Final Jeopardy!
Category: Immunodeficiency
Diseases
Make your wagers now. After you have
made your wager, click anywhere to
continue to the Final Jeopardy answer,
which you will need to write down on your
own paper.
Final Jeopardy!
Category: Immunodeficiency Diseases
This named syndrome is noted by variable T and B
cell populations and is caused by thymic aplasia.
(slide will advance automatically after 30 seconds)
Final Jeopardy
The correct question is...
(click anywhere to see)
What is DiGeorge’s syndrome?
Thanks for playing!
Let me know if you had problems with the program
or if any of the questions/answers are wrong!
Comments are always appreciated as well!
E-mail: [email protected]
End Game By Clicking Here
$200 – “IL” Wind
This cytokine is secreted by T cell to selfpromote development.
What is IL-2?
$400 – “IL” Wind
This cytokine promotes immunoglobulin
switching to IgE.
What is IL-4?
$600 – “IL” Wind
Naïve CD4 T cells developing in the presence of
IL-12 and IFN-gamma become this type of cell.
What is Th-1?
$800 – “IL” Wind
These two cytokines are responsible for the
acute phase inflammation response.
What are IL-1 and IL-6?
$1000 – “IL” Wind
This molecule is expressed on stromal cells
in the thymus and is required for proper TCell development.
What is IL-7?
$200 – Be Sensitive
This type of hypersensitivity reaction is
mediated by histamine, serotonin,
prostaglandins, and chemotactic factors.
What is a Type I ?
$400 – Be Sensitive
The hypersensitivity reaction most
associated with a delay of 24 to 72 hours.
What is a Type IV reaction?
$600 – Be Sensitive
Allergens which directly enter the blood stream are
most likely to cause this disease event?
What is anaphylactic shock?
$800 – Be Sensitive
Along with prostaglandins, this mediator is most
prominent in the late-phase allergic response.
What is leukotrienes?
$1000 – Be Sensitive
Contact hypersensitivities destructive effects
are mediated by activation of this immune
system cell type.
What is macrophage?
$200 – I’m Cured
NSAIDs block this enzyme.
What is cyclo-oxygenase?
$400 – I’m Cured
This powerful cortisol analog is a strong antiinflammatory, but beware of side effects.
What is Prednisone?
$600 – I’m Cured
Anti-leukotriene drugs can help minimize the
effects of this type of disease state.
What are allergies?
$800 – I’m Cured
Cyclosporine is this type of
immunosuppressant.
What is a calcineurin inhibitor?
$1000 – I’m Cured
Monoclonal antibodies against this
substance are showing remarkable ability
to cause remission of rheumatoid arthritis.
What is TNF-alpha?
$200 – Less Than Ideal
The “boy in the bubble” had this type of
immune deficiency.
What is SCID (Severe Combined Immune
Deficiency)?
$400 – Less Than Ideal
This is an isotype switch defect with an
increased amount of IgM and a decreased
amount of other Ig’s.
What is X-Linked Hyper-IgM Syndrome?
$600 – Less Than Ideal
Chediak-Higashi syndrome involves
impairment within this cell type.
What are macrophages?
$800 – Less Than Ideal
This term describes the gene expression
events that allow many eukaryotic
pathogens to avoid the immune response.
What is programmed gene rearrangement?
$1000 – Less Than Ideal
Influenza viruses which cause major
epidemics have had this genetic event
occur.
What is antigenic shift?
$200 – Potpourri
The HIV gene which encodes the viral
capsid proteins.
What is gag?
$400 – Potpourri
The absence of this molecule on antigenpresenting APCs cause T cells to become
anergic.
What is B7?
$600 – Potpourri
The BCR signaling complex is composed of
an antibody and these additional transmembrane proteins.
What are Ig alpha and Ig beta?
$800 – Potpourri
The HIV glycoprotein necessary for viral
integration.
What is gp41?
$1000 – Potpourri
Interaction of Fas with Fas ligand initiates
this cellular process.
What is apoptosis?
$200 – Cell it!
This immunological cell can help eliminate
cancerous cells by innate responses.
What is a Natural Killer?
$400 – Cell it!
These cells are responsible for transporting
pathogens across the intestinal epithelia
layers.
What are M cells?
$600 – Cell it!
Cell responsible for the immediate allergic
response.
What is Mast Cell?
$800 – Cell it!
This interaction provides the primary signal
needed by mature B cells for activation.
What is Ab : Ag?
$1000 – Cell it!
One of two co-receptors HIV uses to adhere
to CD4-containing host cells.
What are CXCR4 or CCR5?
$400 – Barely Tolerated
The name for sites where antigens are kept
separate from most lymphocytes to
prevent an immune response.
What are immunologically privileged sites?
$800 – Barely Tolerated
This is the most important genetic factor
involved in autoimmune disease
pathogenesis.
What is MHC type?
$1200 – Barely Tolerated
Autoimmune Polyendocrinopathy
Candidiasis Ectodermal Dystrophy
involves a genetic defect in this gene.
What is the AIRE gene?
$1600 – Barely Tolerated
This molecule negatively regulates T cell
activation, and mice without this molecule
have a lethal autoimmune
lymphoproliferative syndrome.
What is CTLA-4?
$2000 – Barely Tolerated
Lymphocytes that persistently receive a
primary stimulatory signal without a costimulatory signal are likely to end up in
this inactive state.
What is anergy?
$400 – Innate Talents
These two complement molecules are
chemoattractants for additional
lymphocytic infiltration.
What are C3a and C5a?
$800 – Innate Talents
CD8+CD4- T-cells are associated with this
type of MHC Complex.
What is MHC Class 1?
$1200 – Innate Talents
Toll like receptors are an example of
receptors that bind these molecules.
What are PAMPs
(pathogen associated molecular patterns)?
$1600 – Innate Talents
C3b is this type of molecule that enhances
phagocytosis.
What is an opsin?
$2000 – Innate Talents
This enzyme is primarily responsible for the
oxidative burst in macrophages.
What is NADPH oxidase?
$400 – Organs of the Body
This immune system organ is made up of
red pulp and white pulp.
What is the spleen?
$800 – Organs of the Body
The two immune organs designated as
“primary.”
What are the bone marrow and the thymus?
$1200 – Organs of the Body
The T-Cell zone within the spleen that
surrounds certain blood vessels.
What is the periarteriole lymphoid sheath?
$1600 – Organs of the Body
This lymphatic vessel empties into the left
subclavian vein or the left jugular vein.
What is the thoracic duct?
$2000 – Organs of the Body
Areas of enhanced lymphocytic activity in
the submucosa of the small intestine are
called these.
What are Peyer’s patches?
$400 – Develop Yourself
B cell development is completed in this
organ.
What is the bone marrow?
$800 – Develop Yourself
Most T-cell receptors are made up of these
two chains.
What are alpha and beta?
$1200 – Develop Yourself
Receptor editing (additional chain
rearrangements) occurs in this type of cell
only.
What are B cells?
$1600 – Develop Yourself
Immediately prior to lineage commitment as
CD4 or CD8 cells, T-cells are called this.
What are double positive T cells?
$2000 – Develop Yourself
The principle that there is only one type of
receptor per one lymphocyte is called this.
What is allelic exclusion?
$400 – Signal Received
Found in pentamer form, this is the first type
of immungloublin produced by B cells.
What is IgM?
$800 – Signal Received
Cytotoxic T-cells use this three-lettered
receptor and its ligand to kill infected cells.
What is fas?
$1200 – Signal Received
The process of changing from producing
IgM to producing other immunoglobulins is
called this.
What is isotype switching?
$1600 – Signal Received
Interferon gamma is most associated with
this type of T cell.
What is a Th1 cell?
$2000 – Signal Received
Cells with these two CD numbers regulate T
cells by secreting IL-10 and TGF-beta.
What are CD4/CD25?
$400 – Diagnosis: Immunity
This ABO blood type is the universal donor?
What is O?
$800 – Diagnosis: Immunity
ThoGAM is this type of antibody against Rh
antigen.
What is IgG?
$1200 – Diagnosis: Immunity
A direct Coombs test detects antibodies
bound to this type of cell.
What is a red blood cell/erythrocyte?
$1600 – Diagnosis: Immunity
A type IV delayed hypersensitivity reaction is
used in a skin test for this disease.
What is Tuberculosis?
$2000 – Diagnosis: Immunity
A vaccine for HPV may help to prevent this
type of cancer.
What is cervical cancer?
The End!