Transcript Réponse non spécifique ou innée (2h)

Réponse non spécifique ou innée (2h)
Les cellules Natural Killers et leurs déficits (1h) :
Cellules NK & Immunité Innée
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Part I. Innate Immunity
Qu ickTim e™ e t un
décompresseu r TIFF (non comp ressé )
son t requ is po ur visi onner cette image .
Innate + adaptive immunity
Innate immunity only
From Thomas C. G. Bosch (Kiel)
Histoire d’une découverte
« The dirty little trick »
A paradigm:
Self vs. Non-self
« The structure of scientific revolutions » Thomas S. Kuhn 1962
- « Their achievement was sufficiently unprecedented to attract an enduring group
of adherent away from competing modes of scientific activity »
- « Simultaneously, it was sufficiently open-ended to leave all sorts of problems for
the redefined group of practitioners to resolve »
Paradigm shift:
Une expérience simple
Cold Spring Harb Symp Quant Biol. 1989;54 Pt 1:1-13.
Approaching the asymptote? Evolution and revolution in
immunology.
Insects have an open circulatory
Viruses
Bacteria
system
Dorsal blood
vessel
Fungi
Brain
Protozoa
Hematopoietic
tissues
Gut
Nervous chain
Induction of antimicrobial
activity by immune challenge
Injection of bacteria
Antimicrobial
activity in the
cell-free
hemolymph
Control
0
3
6
9
12
24
Time (h)
48