Transcript Janeway's Immunology

Biophysical Immunology Laboratory
Thomas Vorup-Jensen
Institute for Medical Microbiology and Immunology
University of Aarhus
Denmark
[email protected]
Innate Immunity
Janeway’s Immunobiology Chapter 2&3
Lecture I:(mainly) Cellular factors
Important messanges:
Important cell types supporting innate immunity effector functions
Important molecular mechanisms in leukocyte functions
Molecules of microbial origin triggering an innate immune response
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Innate immunity: a role everywhere in the immune system
Humoral
Immune response
Chap. 10
Cell mediated
immunity
Chap. 8&9
INNATE
IMMUNITY
Antigen capture
Chap. 4-6
Immune
pathogenesis
(autoimmunity
& cancer)
Several chap.
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Figure 8-1
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Figure 8-6
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(macrophages are diffrentiated monocytes)
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Further differentiation to macrophage, DC
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(e.g. defensins, lysozym
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Time
(adaptive immunity)
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Innate Immunity
Janeway’s Immunobiology Chapter 2&3
Lecture I:(mainly) Cellular factors
Important message !:
Innate immunity protects the body against infection in the early phases
of infection
Damage to the host may occur as a consequence of innate immunity
effector functions – inflammation may be excessive
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How to trigger the complement system:
Discrimination between self and non-self by pattern recogniti
Janeway (1989) Cold Spring Harb Symp Quant Biol 54:1-13
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Mogensen (2010) Clin. Rev. Microbiol. 22: 240-273
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Innate Immunity
Janeway’s Immunobiology Chapter 2&3
Lecture I:(mainly) Cellular factors
Important message !:
Many molecules in innate immunity recognize ”patterns” on microbial
surfaces. This recognition leads to triggering on the immune response.
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Innate Immunity
Janeway’s Immunobiology Chapter 2&3
Lecture I:(mainly) Cellular factors
Important message !:
Innate immunity triggers the production bactericidal compounds
and cytokines that control cell migration
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Downloaded from: StudentConsult (on 29 October 2007 04:52 PM)
© 2005 Elsevier
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Carman (2009), J Leuk Biol 122:3025-35
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Innate Immunity
Janeway’s Immunobiology Chapter 2&3
Lecture I:(mainly) Cellular factors
Important message !:
Adhesion molecules play an important role in supporting contact
between leukocytes and inflammed tissue during migration and
phagocytosis.
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Viruses:
typically a job for
the aqcuired immune
system
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…to be continued
Innate Immunity
Janeway’s Immunobiology Chapter 2&3
Lecture II:(mainly) Soluble (humoral) factors
Important messages:
Important soluble molecules supporting innate immunity effector
functions
Connection between molecular structure and function in the immune
system
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