Transcript Uvod u imunski sistem - University of Belgrade

IMMUNOLOGY
Doc. dr Dušan Popadić
Doc. dr Miloš Marković
Ass. dr Emina Savić
Prof. dr Vera Pravica
[email protected]
Tel. 3643-236
Facebook: Antitelija Limfocitic
Welcome to Immunology
Course
Advice
• for successful learning
• and passing the exam
Immunology Course
(40 hours)
Lectures
(12 hrs)
Practice
(Seminars and Labs 28 hrs)
Seminars and Labs during first 14 weeks
Lectures during first 12 weeks
Seminars, Labs and Lectures are integral parts of the course
Student are allowed to be absent on seminar or lab twice
during the semester
In addition to these 40 hrs to prepare the exam
you will need
60 hours of effective work
Preparation of colloquium
and final exam (45 hrs)
Preparation for lectures and
practice (15 hrs)
Lectures
(12 hrs)
Practise
(seminars and labs 28 hrs)
References
Basic Immunology: Functions and Disorders of the Immune System
- Authors: Abbas AK, Lichtman AH.
- Publisher: Elsevier
- 3rd edition updated, 2011
.ppt presentations and authorised supplementary material
(available on web site)
Continuous assessment
activities on the course (seminars, labs and lectures) – through activity
points
presence on lectures noted separately
colloquium – partial, after every 4 weeks (5th, 9th and 13th week)
Colloquium
Test (multiple choice – 1 correct answer out of 4)
It consists of 30 questions in total (divided into 3 mini tests)
1 point for each answer, max 30 points
15 minutes per mini test
- first: in the 5th week
- second: in the 9th week
- third: in the 13th week
Final exam
Final test with combined multiple choice and short answer questions
Threshold for a pass is 31 points, max 60 points
Final mark in Immunology
Final exam mark (60%)
Colloquium score
(30%)
Regularity of
course
attendance
(3%)
Activity on seminars and
labs (7%)
Final mark in Microbiology and Immunology
Final mark in Immunology (25%)
February session→
Final mark in Microbiology (75%)
June session→
Pass in Immunology is a condition for starting the exam in
Microbiology
Introduction to immune system
• Innate and adaptive immunity
• Types of adaptive immunity
• Properties and phases of adaptive immune
response
• Central and peripheral lymphoid organs
• Lymphocyte recirculation
INNATE
(Natural)
(Native)
ADAPTIVE
(Aquired)
IMMUNITY
Principle mechanisms of
innate and adaptive immunity
Principle mechanisms of
innate and adaptive immunity
The most important cells of the immune system
Chain of events in infection
Pathogen(s) enter(s) tissue
Pathogen(s) enter(s) tissue
Pathogen(s) enter(s) tissue
Macrophages recognize (and eliminate) pathogens
Macrophages recognize (and eliminate) pathogens
Macrophages recognize (and eliminate) pathogens
Inflammation is induced and PMNs attracted
Inflammation is induced and PMNs attracted
Antigen-presenting cells (APCs) capture antigen(s)
Antigen-presenting cells (APCs) capture antigen(s)
APCs migrate to draining lymph node
APCs migrate to draining lymph node
APCs migrate to draining lymph node
APCs migrate to draining lymph node
APCs migrate to draining lymph node
APCs migrate to draining lymph node
APCs migrate to draining lymph node
APCs migrate to draining lymph node
APCs migrate to draining lymph node
T cells are activated by APCs
T cells are activated by APCs
T cells are activated by APCs
B cell are activated (helped by T cells)
B cell are activated (helped by T cells)
B cell are activated (helped by T cells)
Activated B cells (plasma cells) produce antibodies (Abs)
Activated B cells (plasma cells) produce antibodies (Abs)
Activated B cells (plasma cells) produce antibodies (Abs)
Activated B cells (plasma cells) produce antibodies (Abs)
Activated T cells and Abs leave lymph node...
... enter blood stream and...
... enter blood stream and...
... migrate to site of infection
... migrate to site of infection
... migrate to site of infection
Activated T cells stimulate phagocytes
Activated T cells stimulate phagocytes
Activated T cells stimulate phagocytes
Activated T cells stimulate phagocytes
Abs neutralize pathogens and stimulate phagocytes
Abs neutralize pathogens and stimulate phagocytes
Abs neutralize pathogens and stimulate phagocytes
Abs neutralize pathogens and stimulate phagocytes
Abs neutralize pathogens and stimulate phagocytes
Pathogen is eliminated
http://instruction.cvhs.okstate.edu/vmed5253/immunobiology.swf
Principle mechanisms of
innate and adaptive immunity
Mechanisms of adaptive immunity
- acquired throughout a lifetime of an individual
- result of previous contact with pathogen
- present in vertebrates
Properties of adaptive immunity
- diversity and specificity
- memory
- clonal expansion
- specialization
- autotolerance
- stimulation of mechanisms of innate immunity
Types of adaptive immunity
Phases of adaptive immune
response
Types of
lymphocytes
Lymphoid organs
Lymph node structure
Lymph node structure
Recirculation of T lymphocytes
The morphology of
the spleen
Introduction to immune system
• Innate and adaptive immunity
• Types of adaptive immunity
• Properties and phases of adaptive immune
response
• Central and peripheral lymphoid organs
• Lymphocyte recirculation
1. Innate immunity is also called
a. phagocytes and NK cells
2. Mechanisms of innate immunity
mediate
b. humoral and cellular immunity
3. First line of defence of innate
immunity is provided by
c. B and T lymphocytes
4. Cells of innate immunity are
d. natural or native immunity
5. Cells of adaptive immunity are
e. diversity, specificity and memory
6. Types of adaptive immunity are
f.
7. Important properties of adaptive
immune cells are
g. early defence against infectious
agents
8. Human central (primary) lymphoid
organs are
h. epithelial barriers
9. Human peripheral (secondary)
lymphoid organs are
i.
peripheral lymphoid organs
j.
lymph nodes, spleen and MALT
10. Primary adaptive immune
response begins in
1._____
2._____
d.
g.
3._____
4._____
h.
a.
bone marrow and thymus
5._____
6._____
7._____
c.
b.
e.
8._____
9._____
f.
j.
10.____
i.