Transcript Activated B cells

Welcome to Immunology
Course
IMMUNOLOGY
Prof. dr Vera Pravica
Prof. dr Dušan Popadić
Doc. dr Miloš Marković
Assist. dr Emina Savić
[email protected]
Tel. 3643-236
Facebook: Antitelija Limfocitic
Advice
• for successful learning
• and passing the exam
Immunology
• independent subject (separated from Microbiology)
• winter semester
• 45 hours during 15 week
Seminars (20)
Lectures (15)
Labs (10)
Seminars, Labs and Lectures are integral parts of the course
Student are allowed to be absent on seminar or lab twice
during the semester
Textbook
Basic Immunology: Functions and Disorders of the Immune System
- Authors: Abbas AK, Lichtman AH.
- Publisher: Elsevier
- 3rd edition updated, 2011
.ppt presentations and authorised supplementary material
(available on web site)
Continuous assessment
Activity during the course (seminars, labs and lectures)
through activity points
Presence on lectures noted separately
Colloquium – divided in three separate mini-tests after every 4 weeks
(5th, 9th and 13th week)
Final test
Colloquium
Test (multiple choice – 1 correct answer out of 4)
It consists of 30 questions in total
(divided into 3 mini tests with 10 questions each)
- first: in the 5th week (first 4 chapters from the textbook)
- second: in the 9th week (chapters 5 to 8)
-third: in the 13th week (chapters 9 to 12 plus immunological methods and vaccines)
1 point for each correct answer (max 30 points)
15 minutes per mini test
Final test
70 points in total
consists of:
• 20 multiple choice questions with one correct answer out of four
(2 points for each correct answer, max. 40 points)
• 5 fill-in questions where correct word should be filled in the blanks
(max. 20 points)
• 2 questions that require short answers up to five sentences
(max. 10 points)
Threshold for passing the final test is 36 points (50% plus 1)
Final mark in Immunology
For the passing of the Immunology exam the minimum of 51 points (out
of 100) should be collected on condition that the 50% of points plus one
(minimally 36) has been reached in the final test
Note: If the student collected less than 15 points in colloqium (i.e. 50%),
he/she must perform better than 36 in the final test
100 points in total
51-60 6 (six)
61-70 7 (seven)
71-80 8 (eight)
81-90 9 (nine)
91-100 10 (ten)
Activity points (max. 10 points) are added only if the minimum of 51 points
has been reached
Introduction to immune system
• Innate and adaptive immunity
• Types of adaptive immunity
• Properties and phases of adaptive immune
response
• Central and peripheral lymphoid organs
• Lymphocyte recirculation
INNATE
(Natural)
(Native)
ADAPTIVE
(Aquired)
IMMUNITY
Principle mechanisms of
innate and adaptive immunity
Principle mechanisms of
innate and adaptive immunity
The most important cells of the immune system
Chain of events in infection
Pathogen(s) enter(s) tissue
Pathogen(s) enter(s) tissue
Pathogen(s) enter(s) tissue
Macrophages recognize (and eliminate) pathogens
Macrophages recognize (and eliminate) pathogens
Macrophages recognize (and eliminate) pathogens
Inflammation is induced and PMNs attracted
Inflammation is induced and PMNs attracted
Antigen-presenting cells (APCs) capture antigen(s)
Antigen-presenting cells (APCs) capture antigen(s)
APCs migrate to draining lymph node
APCs migrate to draining lymph node
APCs migrate to draining lymph node
APCs migrate to draining lymph node
APCs migrate to draining lymph node
APCs migrate to draining lymph node
APCs migrate to draining lymph node
APCs migrate to draining lymph node
APCs migrate to draining lymph node
T cells are activated by APCs
T cells are activated by APCs
T cells are activated by APCs
B cell are activated (helped by T cells)
B cell are activated (helped by T cells)
B cell are activated (helped by T cells)
Activated B cells (plasma cells) produce antibodies (Abs)
Activated B cells (plasma cells) produce antibodies (Abs)
Activated B cells (plasma cells) produce antibodies (Abs)
Activated B cells (plasma cells) produce antibodies (Abs)
Activated T cells and Abs leave lymph node...
... enter blood stream and...
... enter blood stream and...
... migrate to site of infection
... migrate to site of infection
... migrate to site of infection
Activated T cells stimulate phagocytes
Activated T cells stimulate phagocytes
Activated T cells stimulate phagocytes
Activated T cells stimulate phagocytes
Abs neutralize pathogens and stimulate phagocytes
Abs neutralize pathogens and stimulate phagocytes
Abs neutralize pathogens and stimulate phagocytes
Abs neutralize pathogens and stimulate phagocytes
Abs neutralize pathogens and stimulate phagocytes
Pathogen is eliminated
http://instruction.cvhs.okstate.edu/vmed5253/immunobiology.swf
Principle mechanisms of
innate and adaptive immunity
Mechanisms of adaptive immunity
- acquired throughout a lifetime of an individual
- result of previous contact with pathogen
- present in vertebrates
Properties of adaptive immunity
- diversity and specificity
- memory
- clonal expansion
- specialization
- autotolerance
- stimulation of mechanisms of innate immunity
Types of adaptive immunity
Phases of adaptive immune
response
Types of
lymphocytes
Lymphoid organs
Lymph node structure
Lymph node structure
Recirculation of T lymphocytes
The morphology of
the spleen
Introduction to immune system
• Innate and adaptive immunity
• Types of adaptive immunity
• Properties and phases of adaptive immune
response
• Central and peripheral lymphoid organs
• Lymphocyte recirculation
1. Innate immunity is also called
a. phagocytes and NK cells
2. Mechanisms of innate immunity
mediate
b. humoral and cellular immunity
3. First line of defence of innate
immunity is provided by
c. B and T lymphocytes
4. Cells of innate immunity are
d. natural or native immunity
5. Cells of adaptive immunity are
e. diversity, specificity and memory
6. Types of adaptive immunity are
f.
7. Important properties of adaptive
immune cells are
g. early defence against infectious
agents
8. Human central (primary) lymphoid
organs are
h. epithelial barriers
9. Human peripheral (secondary)
lymphoid organs are
i.
peripheral lymphoid organs
j.
lymph nodes, spleen and MALT
10. Primary adaptive immune
response begins in
1._____
2._____
d.
g.
3._____
4._____
h.
a.
bone marrow and thymus
5._____
6._____
7._____
c.
b.
e.
8._____
9._____
f.
j.
10.____
i.