Transcript Slide 1
Journal Club of Veterinary Medicine, 18 October 2007 Infection of parasite nematodes confounds vaccination efficacy (Urban et al. 2007) Ingeniøren, 13 October 2007 If you want to be innovative? The get rid of the laid back attitude! It has to hurt a little to participate in an innovation project. If it is too fun and cozy, it does not move, concludes a ph.d.-dissertation. Immune System Adaptive Immune System T-cell development Cytokines can prime of T helper cells development Th0 INF IL4 IL12 IL13 TNF IL10 Th1 Th2 Intracellular Extracellular “Infection of parasite nematodes confounds vaccination efficacy” Veterinary Parasitology. 2007 August 19; 148(1): 14-20 (Urban et al. 2007) General vaccination strategy + Vaccination Antibodies Cytokines (IgG1, IgG2) Challenge (2nd vaccination) “Infection of parasite nematodes confounds vaccination efficacy” Veterinary Parasitology. 2007 August 19; 148(1): 14-20 (Urban et al. 2007) Mouse model + + Nematode Vaccination Heligomosomoides polygyrus Plasmodium yoelii (malaria antigen, mice) • IL3 • IL4 • IL5 • IL9 • IL13 • IgG1 & IgE INF IL4 IL13 IL10 TGF Challenge (2nd vaccination) “Infection of parasite nematodes confounds vaccination efficacy” Veterinary Parasitology. 2007 August 19; 148(1): 14-20 (Urban et al. 2007) Pig model + + Nematode Vaccination Ascaris suum Mycoplasma hyopneumonia (commercial killed vaccine) • Weak Th1 (lungs) • Th2 (intestine) Challenge (2nd vaccination) • 33% specific antibody response to M. Hyopnemonia. • Serum conversion did not exceed 78 %. • More lung pathology Parasitic infections as medicine Chron’s Disease (regional interitis) An inflammatory bowel disease Autoimmune disease Th1-dominated Th2 Thank you for listning!