Transcript Document
Diverse studies on the role of inflammation in disease Basic to applied research Bruce Walcheck: Role of neutrophils in acute lung injury, bacterial lung infection, and sepsis (cell based assays and in vivo studies in mice). Sriram Rao and Mathur Kannan: Eosinophil and smooth muscle cell influences on asthma and airway hyperresponsiveness (cell based assays and in vivo studies in mice). Jennifer Granick: Role of hematopoietic and progenitor cell derived neutrophils in infection (S. aureus skin infection) (cell based assays and in vivo studies in mice). Jimmy Wu: Immunogenetics of human inflammatory diseases e.g., lupus, rheumatoid arthritis, and cardiovascular diseases. Maxim Cheeran: Mechanisms of neuroinflammation during viral encephalitis (cell based assays and in vivo studies in mice). Yuying Liang: Influenza virus-induced airway inflammation and the role of epithelial cells, and innate and adaptive immune cells (cell based assays and in vivo studies in mice). Scott O’Grady and Tamene Melkamu: Innate immune functions by epithelial cells, eosinophils, and macrophages in the lungs (cell based assays and in vivo studies in mice) Alice Larson: Role of mast cells in the brain in the regulation of pain (cell based assays and in vivo studies in mice and rats). Al Beitz: Cancer inflammation and effects on pain (cell based assays and in vivo studies in mice and rats). Zheng Xing: Host responses in birds infected with avian influenza (in vitro and in vivo studies in mice and avian species). John Collister: Central nervous system regulation of hypertension and heart failure (in vivo studies in rats). Lucy Vulchanova and Sheila Torres: Organotypic cultures of primary keratinocytes from normal and atopic dermatitis dogs to test the effects of drugs on barrier function and innate immune responses (cell based assays and in vivo studies in rats and dogs). Mike Murtaugh: Pathogenesis of lung inflammation during bacterial and viral pneumonia (cell based assays and in vivo studies in pigs). Srinand Sreevatsan: Macrophage-pathogen interactions during mycobacterial and influenza infections (in vitro and in vivo studies in mice, birds, pigs, cattle). Sandra Godden: Examining the effects of NSAIDs on inflammatory/immune response/pain in calves undergoing dehorning (in vitro and in vivo studies in cattle). Ricardo Chebel: Study various influences on innate immune functions and antibody responses before and after birth in cows – endometritis, metritis and mastitis (in vitro and in vivo studies in cattle). Troy Trumble: Discovery and translational research focusing on the onset and progression of osteoarthritis (horse) Sheila Torres: Preclinical and clinical trials to test the safety and efficacy of anti-inflammatories for atopic dermatitis (dogs). Mike Conzemius: Preclinical and clinical trials to test the safety and efficacy of anti-inflammatories and analgesics for synovitis and osteoarthritis (dogs). Diverse animal models Induced to natural disease Murine: Sepsis, endotoxemia, neuro-inflammation, asthma, lung injury, host response to infection, mast cells in CNS, cancer inflammation, cardiovascular disease…. Avian: Influenza, salmonella, ExPEC…. Porcine: Viral pneumonia, Influenza, autoimmunity…. Canine: SIRS, atopic dermatitis, synovitis, osteoarthritis…. Equine: Osteoarthritis, colic, endometritis, laminitis…. Bovine: Mycobacterial infection, pain, endometritis, metritis and mastitis…. Veterinary Clinical Investigation Center Equine Research Center membrane-associated protein shed protein Membrane -proximal region ADAM17 Outcome Measures for Pain and Inflammation Tekscan Pressure Mat 3D Kinematics Force Platform Gait Analysis Animal Activity Monitoring