Transcript ppt - UMD Biology - University of Maryland

Jonathan Simon
Biology / Electrical & Computer Engineering
University of Maryland, College Park
Thanks to Luiz Pessoa for MNC slides
 NSF
grant by NACS faculty
3 Tesla Siemens MRI machine
 Funds
from the campus: $2-3 million
• Broad support across several colleges (BSOS,
ENGR, CMNS, etc.)
 Northeast
of campus
• Across route 193
• Off Metzerott road
 Multiple
modalities for brain research
• MRI
• EEG: Electroencephalography (soon)
• MEG: Magnetoencephalography (~ 1 year)
http://ling.umd.edu/assets/photos/2011/06/07/KIT_MEG_350x350.jpeg
http://uuhsc.utah.edu/uumsi/images/sensor_array.jpg
 Basic
studies of perception, cognition,
and emotion
 Clinically relevant research
• Autism, Dyslexia, Anxiety, Addiction, etc.
 Work
with adults and children
• Not yet with animals (only barrier is $$)
 Determine “activations” to
task conditions
Region does X!
e.g. , V1 “does”
orientation processing
http://t2.gstatic.com/images?q=tbn:ANd9GcTu4yd12HA97oU222KOoUrVELjAE5kVdhVS_71JOAYq2woSjJGr
 Ocular
dominance columns
• Because of the connectivity from eye to cortex,
eye-of-origin related columns exist in early
visual cortex
Horton
 Ocular
dominance
columns with fMRI
session 1
• In-plane resolution:
470 x 470 µm
• Column width: 1.1 mm
session 2
Horton
SA
 Machine
states
learning to “decode” brain
What is the person seeing?
 Graph-theoretic
analysis
• How are brain regions organized as a function of
condition, population (autism vs. control), etc.?


Nodes: brain regions
Edges:
“functional connectivity”
between regions
• Correlation
 Reconstructing
physical connection paths
http://www.epicareflorida.com/images/
Hippocampal_sclerosis.jpg
http://3.bp.blogspot.com/XaZAD5nhhH4/TVbUkY0aJjI/AAAAAAAAHis/dZXN82sE03o/s1600/
Fiber_Tractography.JPG
 Run
the same experiment with functional
MRI and MEG
 Integrating the two modalities
• Spatial resolution of functional MRI
• Temporal resolution of MEG
t = 32 ms
t = 38 ms
From Ou et al (2009)
 $600/hour
 Seed
funding available
• Faculty
• Students + Faculty
• Idea is that pilot data will be used for grant
application to support research
 Meets
every other Friday from noon-1
• Focus on MRI, MEG, and EEG related work
• Open to all techniques that study the brain!
 Come
visit sometime!
http://www.thecnnh.org/ACEC/images/jimmysmile_phan.jpg