Transcript Excerpt-from-Uveitis-Medical-Affairs-training-slide-deck-1

CONFIDENTIAL – FOR INTERNAL TRAINING PURPOSES ONLY
OCULAR INFLAMMATION AND UVEITIS
EYE CARE
CONFIDENTIAL – FOR INTERNAL TRAINING PURPOSES ONLY
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This is an excerpt from a series of interactive slide decks that were
transferred to the program Articulate. The deliverable included instructions
for animation as well as a voiceover script. While the interactive product is
no longer available as a writing sample, this excerpt is offered to
demonstrate PowerPoint skills.
CONFIDENTIAL – FOR INTERNAL TRAINING PURPOSES ONLY
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Treatment of Uveitis
CONFIDENTIAL – FOR INTERNAL TRAINING PURPOSES ONLY
Treatment of Uveitis
Goals of Therapy
● Suppress inflammation
● Avoid complications
CONFIDENTIAL – FOR INTERNAL TRAINING PURPOSES ONLY
Review of Ophthalmology. http://www.revophth.com/content/d/features/i/1305/c/25117/
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Treatment of Uveitis
Standard Treatments
● Cycloplegics
–
Dilate the pupil
–
Relieve some pain
–
Prevent anterior synechiae
● Antimicrobials
–
Used in infectious uveitis
● Corticosteroids
–
The gold standard of treatment
–
Block the inflammatory cascade at its origin
–
Modulate other inflammatory mediators
CONFIDENTIAL – FOR INTERNAL TRAINING PURPOSES ONLY
Allergan. http://www.allergan.com/assets/images/US/products/pred_forte.jpg.
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Treatment of Uveitis
Standard Treatments
● Corticosteroid Delivery
–
Topical
–
Periocular
–
Systemic
–
Intravitreal

Triamcinolone injections

Implantable devices
(eg, Retisert®, Ozurdex™)
CONFIDENTIAL – FOR INTERNAL TRAINING PURPOSES ONLY
Mohawk Valley Retina. http://www.mvretina.com/education/images/injws_000.jpg.
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Treatment of Uveitis
Other Treatments
● Antimetabolites
–
Azathioprine (Imuran)
–
Methotrexate
–
Mycophenolate (CellCept®)
● T-cell inhibitors
–
Cyclosporine
–
Tacrolimus (Prograf®)
● Cytotoxic agents
–
Cyclophosphamide (Cytoxan)
–
Chlorambucil (Leukeran®)
CONFIDENTIAL – FOR INTERNAL TRAINING PURPOSES ONLY
http://www.drug3k.com/img2/imuran_10554_5_(tb)_.jpg
http://www.drug3k.com/img2/cellcept_10987_5_%28big%29_.jpg.
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Treatment of Uveitis
Other Treatments
● Anti-tumor necrosis factor-α
–
Adalimumab (Humira®)
–
Infliximab (Remicade®)
● Anti-interleukin-2 receptor
–
Daclizumab (Zenapax)
● Anti VEGF
–
Bevacizumab (Avastin) or
–
Ranibizumab (Lucentis®) for refractory
CME and neovascular complications of uveitis
CONFIDENTIAL – FOR INTERNAL TRAINING PURPOSES ONLY
Ophthotech Corporation.
http://www.ophthotech.com/wp-content/gallery/e10030/e10030c_lg.jpg
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