Transcript The Reductionistic Journey of the Y

The reductionistic journey of the Y-chromosome
the last 300 million years
Sigbritt Werner
Professor in Endocrinology
Karolinska Institutet
Levels of genus (lat) and gender (eng)
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chromosomal sex
hormonal sex
anatomical sex
phenotypical sex
sexual orientation
sexual identity
sexual role
social sex
Hormones
stimulators
Signal substances
inhibitors
peptides
steroids
ions
gases
acids
bases
temperature
viscosity
nutritional status
Some gender differences in disease incidence
female
dominance
hypothyroidism
hyperthyroidism
ACTH prod
pituitary tumours
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thyroid cancer
pyloric stenosis
adrenal aplasia
male
dominance
growth hormone
prod pituitary
tumours
Lupoid hepatitis
type 1
P Biliary Cirrhosis
Scleroderma
Sjögren’s syndrome
Systemic Lupus
Erythematosus
Rheumathoid Arthritis
Autoimmune diseases
schizophrenia
migraine
subarachnoid
hâmorrhage
multiple sclerosis
epilepsy
melanoma
stroke
other
skin
cancers
Mb Reiter
Mb Bechterew
Pelvospondylitis
X-transduced recessive diseases
Haemophilia
Fabry’s syndrome
Adrenoleukodystrophia
Applying the sex ratio coefficient (i.e., -11.2422) from Table 1 to these values suggests that the males in
Sweden's "least culled" birth cohort (i.e., 1910) lived, on average, 3 (i.e., 11.2422 x 12 x 0.0215 = 2.9)
fewer months than expected from the lifespan of females in that cohort as well from historic trends unique to
male cohort lifespan. Those in the most "most culled" cohort (i.e., 1784), on the other hand, lived 3.7 more
months than was expected from history and from the lifespan of females in that cohort.
This improves the mother’s chance of grandchildren since weak sons produce
fewer offsprings than weak daughters