Transcript Role of Resveratrol in Cell Health and Longevity

Curcumin Extreme™
Julian Blumenfeld, MD
Chief Medical Officer
Market America & nutraMetrix
Curcumin Extreme™
Code: 13145 and 13145NM
Curcumin Extreme™
• Curcumin (BCM-95®): 400 mg
• Broccoli Seed Extract (6% Glucosinolates): 167 mg
• Selenium (Selenomethionine): 100 mcg
Curcumin
•Turmeric root extract
•3 major curcuminoids
•Curcumin
•Demethoxycurcumin
•Bis-demethoxycurcumin
Curcumin: Biological Activities
• Powerful antioxidant
•Reduces
superoxide
anions
• Promotes
normal
activity
of NF-kappaB
•Reduces peroxides
•Inhibits
LDL oxidation
and lipid
peroxidation
• Promotes
normal
cell cycle
activity,
normal
cellular regeneration
• Promotes neurological health, helps to
maintain neurological health as we age
Curcumin: Biological Activities
• Powerful antioxidant
• Promotes normal activity of NF-kappaB
In unhealthy cells, curcumin has been shown to
•interfere
Promotes
normal
cell cycle
activity, normal
with multiple
cell signaling
pathways,
including
cellregeneration
cycle (cyclin D1 and cyclin E) and
cellular
apoptosis.
-Anand, P., etneurological
al. Curcumin and cancer:
an “old-age”
diseaseto
with
• Promotes
health,
helps
an “age-old” solution. Cancer Letters. 267: 133-164, 2008.
maintain neurological health as we age
Curcumin: Biological Activities
Curcumin: Biological Activities
• Powerful antioxidant
• Promotes normal activity of NF-kappaB
Curcumin can cross the blood-brain barrier and bind
•directly
Promotes
normal
cycle activity,
normal
to amyloid
plaquescell
and increase
the uptake
of
amyloid-β
protein
by macrophages.
cellular
regeneration
-Zhang, L., et al. Curcuminoids enhance amyloid-beta uptake by macrophages
• ofPromotes
neurological
to1-7, 2006.
Alzheimer’s disease
patients. Journal ofhealth,
Alzheimer’s helps
Disease. 10:
maintain neurological health as we age
Curcumin: The BCM-95® Difference
Broccoli Seed Extract (6% Glucosinolates)
• Promotes the normal production of
detoxification enzymes
• Helps maintain healthy
Cytosolglutathione
levels
H H
Nucleus
S S apoptosis in unhealthy
• Promotes
cells
keap1c
keap1m
• Promotes a strong
immune system
nrf2
keap1m
keap1c
S
H
S
H
ARE
GST’s, GR, GPx, HO-1
Broccoli Seed Extract (6% Glucosinolates)
• Promotes the normal production of
detoxification enzymes
• Helps maintain healthy glutathione levels
• Promotes apoptosis in unhealthy cells
• Promotes a strong immune system
– Enhance total white blood cell count
– Enhance phagocytic activity
– Reduced elevated TNFα from LPS stimulated
macrophages
-Thejass, P. and Kuttan, G. Immunomodulatory activity of sulforaphane, a naturally occuring
isothiocyanate from broccoli (Brassica oleracea). Phytomedicine. 14: 538-545, 2006.
Selenium (Selenomethionine)
•
Required cofactor for selenoproteins
– Glutathione peroxidase enzymes
Glutathione
H
H
H
Glutathione
H
O
O
H
H
– Iodothyronine deiodinase enzymes
Thyroxine (T4)
Thyroid Hormone (T3)
-Brown, K. and Arthur, J. Selenium, selenoproteins and human health: a review.
Public Health Nutrition. 4: 593-599, 2001.
Curcumin Extreme™
Directions: Take one capsule per day, with or without a meal.
Warning: If you are currently taking warfarin (Coumadin) or
other anti-platelet/anti-coagulant medications, you should
not take this product. If you are taking any other
prescription drugs or have an ongoing medical condition,
you should consult your physician before using this product.
Women who are pregnant or nursing should not take this
product.
Summary
• Curcumin Extreme™
– Curcumin (BCM-95®): 400 mg
– Broccoli Seed Extract (6% Glucosinolates): 167 mg
– Selenium (Selenomethionine): 100 mcg
• Why curcumin? Why now?
• Who would benefit?
Curcumin Extreme™
Code: 13145 and 13145NM
DC:
$28.50
SR:
$39.95
BV:
23