Transcript Head and Neck Cancer

Head & Neck Cancer Research
Report
Site Specific Group Meeting
Tuesday 9th June 2015
Maxine Taylor
Senior Research Delivery Manager
Delivering clinical research to
make patients, and the NHS, better
Content of report
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Overview of network changes
Overview of research activity
New studies for the portfolio
Request for research lead
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Introduction
• NIHR Clinical Research Network merged all cancer
research networks with all other clinical research
networks in England on 1st April 2014
• CRN - West of England is one of 15 new networks
• This new geography does not map exactly to the site
specific group geography. It now includes
Gloucestershire and Swindon but no longer includes
Taunton and Yeovil
• Taunton and Yeovil are served by the CRN – South West
Peninsula
• I will work closely with my counterpart in South West
Peninsula to support this SSG in full
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Map showing the 15 Clinical Research Networks in England
West of England
• Population 2.4 million
• - Budget £13.2 million
• - 7 Acute Trusts
• - 2 Mental Health Trusts
• - CCL Principal Treatment Centre
• - Full team only since December
2014
• - Small core support team based at
host in Bristol
• Research will follow patient
pathways regardless of network
geography
Purpose of the network
• Translation of national workstreams and objectives (generic
and specialty specific) with strategic oversight of research
activity within the geography of CRN - West of England in
terms of:
– Portfolio
• Balance, new studies, feasibility, industry trials
– Performance
• Targets, support timely set up, support timely
recruitment
– People
• Skill mix, workforce flexibility, resources, training
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CRN - West of England Management
Model
• Division
1
• Division
5
Maxine Taylor
Mary Griffin
Senior RDM
Workforce
Development
RDM
RM&G and
Industry
Mary Perkins
Chief Operating Officer
• Divisions
3&4
Chantal Sunter
Ruth Allen
RDM
RDM
Patients & Public &
Communications
Business
Intelligence
• Divisions
2&6
Network Clinical Divisions
Division 1
• Cancer
Division 2
• Diabetes
• Stroke
• Cardiovascular
Renal
Metabolic & endocrine
Division 3
• Children
• Genetics
Division 4
• Mental Health
• Dementias & neurodegenerative diseases
• Neurology
Division 5
• Primary care
research
• Oral & dental
• Musculoskeletal
Ageing
Division 6
• ENT
• Surgery
• Respiratory
• Critical care
• Hepatology
Anaesthesia & pain management
Critical care
Opthalmology
Infectious diseases
Gastroenterology
Reproductive health & childbirth
Haematology
Health services
Dermatology
Public Health
The Clinical Team
Dr Steve Falk
Clinical Director
6 Divisional Clinical Leads
Prof Hugh Barr for Div 1
30 Specialty
Leads
Sub Specialty
Leads
Sue Taylor
Network
Consultant Nurse
Clinical
Research Teams
NIHR CRN High Level Objectives
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Set up as fast as you can
Recruit as many and as fast as you can
All organisations involved
Commercial and non commercial portfolio studies
Cancer specialty specific objectives
• Recruitment overall at 20% cancer incidence
• Recruitment to interventional studies at 7.5% of cancer
incidence
• Recruitment to rare cancer studies
How important is cancer on our patch?
Research staff WTE per
division
Div 1
58
67
Div 2
Div 3
23
34
17
20
21
Div 4
Div 5
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Div 6
Generic
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Cancer incidence 9544
242 recruiting studies
£2 million (16%)
Funding per incident case
approx £220
Funding per recruit £800
Exceeded both recruitment
targets for last 2 years
Largest non commercial
portfolio
Benefit from continued good
national and international links
Chart 8: CRN: West of England Performance against Specialty goals 14/15
7000
6000
5000
4000
3000
2000
1000
0
Recruitment 2014/15
Recruitment goal 2014/15
Chart 11a: Recruitment to Cancer specialty by CRN: West of England
partner organisations 2013/14 - 2015/16 †
1000
888 909
900
800
Recruitment
700
600
500
400
403
434
377
363
294
300
225 200
249
246
200
100
127
28
15
15
25
36
4
0
Gloucestershire Hospitals Great Western Hospitals North Bristol NHS Trust Royal United Hospitals University Hospitals Weston Area Health NHS
NHS Foundation Trust NHS Foundation Trust
Bath NHS Foundation Bristol NHS Foundation
Trust
Trust
Trust
2013/2014
2014/2015
2015/2016 (April 2015)
Recruiting studies
Study Acronym/Title
Taunton and
Somerset
Gloucestershire Royal United NHS
Hospitals NHS Hospital Bath Foundation
Foundation Trust NHS Trust
Trust
ART DECO
De-ESCALaTE HPV
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3
Developing a core information set for
consent to oral cancer surgery
HeadandNeck5000 – now closed
IoN
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12
8
3
NIMRAD (NIMorazole/placebo plus
RADiotherapy in head and neck cancer)
Grand Total
20
15
8
University
Hospitals
Bristol NHS
Foundation
Trust
Grand
Total
3
3
9
17
98
98
93
125
7
10
2
2
212
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National Portfolio
• 6 studies in set up. Only 1 open to new sites
EORTC 1209EnTF
A phase II study exploring the safety and efficacy of nintedanib (BIBF1120) as second
line therapy for patients with either differentiated or medullary thyroid cancer
progressing after first line therapy.
43 Studies on National Portfolio
Only a few open to new sites
HOPON - (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis): A
Randomised Controlled Trial of Hyperbaric Oxygen to prevent Osteoradionecrosis of
the Irradiated Mandible. Closing 2018, 62% recruited.
DAHANCA 21 - Hyperbaric oxygen treatment of mandibular osteoradionecrosis. A
randomized clinical study. Closes Dec 2018. 2% recruited so far.
Head and Neck Cancer: molecular, cellular and immunological mechanisms Investigation of the molecular and genetic mechanisms promoting oral cancer
development and progression. Closing March 2020, 45% recruited.
Head and neck skin malignancy - Investigating molecular and cellular mechanisms of
head and neck skin malignancy. Closing April 2019, 12% recruited so far.
IoN Is ablative radio-iodine necessary for low risk differentiated thyroid cancer
patients. Closing May 2016, 45% recruited.
2 further studies open to new sites but nearing closure date.
Cancer Subspecialty Research Leads
• Within each network 13 subspecialty research lead roles
are identified, mapping onto the national Clinical Studies
Groups with the aim of:
– Providing link between local network and CSGs
– Promoting the research agenda to clinical colleagues
across the network
– Advising on portfolio planning locally
– Attendance at annual meeting to discuss portfolio
planning and delivery and horizon scan for new
studies
– Supporting the research delivery manager for the
cancer specialty
• Role very similar to SSG Research Lead role
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National Clinical
Studies Groups
Psychosocial &
Survivorship
Brain
Tumours
Head & CSG
Palliative &
Neck
Supportive
CSG
Care
Sarcoma
CSG
Breast
Cancer
CSG
Imaging
Adv. panel
Lung
Cancer
CSG Upper GI
Biomarkers
Adv. panel
Cancer
CSG
Colorectal
Cancer
Consumer
CSG
Melanoma
Liaison
PPI
Kidney
CSG
Group
Cancer
Primary
CSG
Lymphoma
Care
Bladder
CSG
Cancer
Screening,
Testis CSG
Haematol.
Prevention &
Cancer
CSG Prostate
Gynae
Early Diagnosis
CSG
Children’s
Cancer
Cancer
Cancer &
CSG
CSG
Teenage &
Leukaemia
Young Adult
CTRad
(Radiotherapy)
LCRN (x15)
CRN WE Exec Board
Partnership Group
Clin. Advisory Group
Clinical Director
COO
Division 1 Clinical Lead
Division 1 RDM
[ +/- other clinical roles]
13 LCRN Subspecialty Leads:
•Brain cancer
•H&N cancer
•Lung cancer
•Breast cancer
•Sarcoma
•Skin Cancer
•Children/young people
•Upper GI cancer
•Colorectal cancer
•Urological cancer
•Gynae cancer
•Haem/lymphoma
•Pall/Supportive &
Psychosocial
Research Delivery
Teams
Call for H&N sub-specialty lead
in CRN - West of England
• Each SSG already has a research lead
• We are looking for a research lead in each tumour site to
represent the network locally and nationally in terms of
developing and supporting the portfolio and providing
clinical specialty support to the Research Delivery
Manager and Principal Investigators across the network
• Expenses to attend national meetings will be met by the
network
• Discussion:
– Your current research lead continuing and taking on
the network representation and/or
– The nomination of a West of England research lead
who will take on network representation
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Contact & reference details
• [email protected]
• [email protected]
• http://csg.ncri.org.uk/portfolio-maps/
• https://www.edge.nhs.uk/Account/Index?ReturnUrl=%2f
• http://www.crn.nihr.ac.uk/can-help/fundersacademics/nihrcrn-portfolio/
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