Transcript Three Counties Cancer Research Network Research Network

Stakeholders In Clinical
Research
Research Networks
R&D Drivers
Professor Phil Warner
What are research Networks?
• A managed Topic Specific Clinical
Research Network,
• It may involve a Primary Care Research
Network and a Comprehensive NHS
Research Network.
• It aims to bring an integrated approach to
clinical research involving several
research teams, patients etc.
Definition of a research Network
• Must conduct research in human subjects or use
data from human subjects to improve human
health
• Surveillance systems and registries eligible if
there has been some research output
• Must have scientific leadership that either
develops research ideas and protocols or
evaluates ideas and protocols bought to it by
outside individuals or organisations
Definition of a research Network
• Must demonstrate multi-study capability by
publishing at least two studies from within the
group of institutions
• Must include at least three participating entities
• At least 3 entities must be independent or semi
independent from each other
• At least 3 entities must have some independent
decision making ability about the research in
which they participate
Definition of a research Network
• Network support systems and networks
facilitated to enable sharing of resources
between organisations are therefore not
research networks
• These definitions are intended in the U.K.
to help evaluate research networks
• The National Institute for Health Research
Clinical Research Network Coordinating Centre
(NIHR CRN CC) supports clinical research
and helps to facilitate the conduct of trials and
other well-designed studies within the NHS.
The NIHR Clinical Research Network (NIHR
CRN) in England is one of the four networks that
comprise the UK Clinical Research Network
(UKCRN). (Others in Scotland, Wales Northern
Ireland
So Let’s Take a Look
at Some Networks
• The NCRN was established in April 2001, and
aims to provide the NHS with an infrastructure to
support high quality cancer clinical studies and
to improve the speed, quality and integration of
research resulting in improved patient care.
• The NCRN has achieved and surpassed its
target to double the number of cancer incident
cases accrued into cancer clinical studies.
• This success contributed to the decision by the
Department of Health to establish the NIHR
CRN CC, expanding the concept into other
disease areas.
• The NCRN will increase involvement and recruitment
into trials through the creation of cancer research
networks across England, closely aligned to cancer
service networks. NCRN funding is allocated to networks
to appoint research staff, such as research nurses, data
managers and medical staff sessions and to access
pharmacy, pathology, radiology and other areas of
support, such as information systems and training, all of
which are integral to high quality research.
Thirty two cancer research networks have been
established. Each network is required to appoint a
clinical and administrative lead (Clinical Lead for
Research and Research Network Manager) with
responsibility for the overall leadership and management
of the local networks.
Three Counties Cancer Research
Network
• Three Counties Cancer Research Network
• Clinical Lead for Research: Professor Hugh
Barr
• Address: Three Counties Cancer Research
Network
Gloucestershire Royal NHS Trust
Great Western Road
Gloucester
GL1 3NNTelephone N°: 08454 226679Fax N°:
08454 226813Email: [email protected]
Three Counties Cancer Research
Network
• Research Network Manager:
Maxine Taylor
Three Counties Cancer Research Network
The Chapel
St Paul's Medical Centre
Swindon Road
Cheltenham
Glos
GL50 4DPTelephone N°: 01242 215052Fax N°:
01242 215456Email:
[email protected]
Three Counties Cancer Research
Network
• Trusts in the Network
• GLOUCESTERSHIRE HOSPITALS NHS
FOUNDATION TRUST
• FOUNDATION TRUST FOR
GLOUCESTERSHIRE
• HEREFORD HOSPITALS NHS TRUST
• WORCESTERSHIRE ACUTE
HOSPITALS NHS TRUST
3CCRN Colorectal / Lower
Gastro-Intestinal / Bowel Cancer
Trials
• The second UK Phase III anal cancer trial: A trial of
Chemoradiation and Maintenance Therapy For Patients
with Anal Cancer.
• Chemotherapy or no chemotherapy in clear margins
after neoadjuvant chemoradiation in locally advanced
rectal cancer. A randomised phase III trial of control vs
capecitabine plus oxaliplatin
• Phase III trial comparing either chemotherapy plus
cetuximab or intermittent chemotherapy with the
standard continuous palliative combination
chemotherapy with oxaliplatin and a fluoropyrimidine in
first line treatment of metastatic colorectal cancer.
3CCRN Colorectal / Lower
Gastro-Intestinal / Bowel Cancer
Trials
• Follow-up After Colorectal Surgery. A
randomised controlled trial to assess the cost
effectiveness of intensive versus no scheduled
follow-up in patients who have undergone
resection for colorectal cancer with curative
intent
• Drug treatment for bowel cancer: making the
best choices when a milder treatment is needed.
NSCCG 22 March 2005 National Study of
Colorectal Cancer Genetics.
Industry
• The UK has a strong history in clinical
research and the healthcare industry has
made a significant contribution to this track
record through the conduct of its research
and development programmes in the NHS.
The NIHR CRN is working to address the
specific challenges and pressures faced
by the healthcare industry in this area.
Industry
• As for all other research taken on by the networks,
industry-contract studies must be formally adopted by
the NIHR CRN.
• The NIHR CRN industry team has developed a process
specifically for the adoption of industry-contract studies
which has been informed by discussions with industry
through the NIHR CRN Industry Road Map Group.
• The process takes into account the needs of industry, in
particular, the time constraints faced by companies.
• The Industry Trials Adoption Process is a highly
streamlined process in order to meet the tight timelines
often required by industry.
Patients and Public
• NIHR CRN CC aims to improve patient
care and allow people across the country
access to the best treatment. A common
theme that runs throughout its work is
Patient and Public Involvement (PPI)
because NIHR CRN CC believes that
active PPI is needed if it is to achieve a
programme of research which directly
reflects the needs and views of patients
and the public..
Dementias and
Neurodegenerative Diseases
Research Network
(DeNDRoN)
• The Dementias and Neurodegenerative
Diseases Research Network (DeNDRoN)
facilitates the conduct of randomised
prospective trials and other well-designed
studies of the dementias and
neurodegenerative diseases, including
those for prevention, diagnosis and
treatment
• The creation of a UK research network for
dementias and neurodegenerative
diseases allows a sharing of resources
and methodological expertise across a
wide range of disabling long-term
disorders which we recognise to share
many common factors.
• It builds on the strengths already present
in the UK as well as increasing general
capacity in the field of dementia and
neurodegeneration and will cover major
diseases including Alzheimers, Motor
Neurone Disease, Parkinson’s Disease
and Huntington’s Disease.
The Networks
•
•
•
•
•
•
•
•
•
East Anglia (Hosted by Norfolk and Waveney Mental Health Partnership
NHS Trust, led by Dr Andrew Tarbuck)
North East (Hosted by Newcastle, North Tyneside and Northumberland
Mental Health NHS Trust, led by Professor John O'Brien)
North Thames (Hosted by Camden and Islington Mental Health and Social
Care NHS Trust, led by Dr Craig Ritchie)
North West (Hosted by Manchester Mental Health and Social Care Trust,
led by Dr Jane Byrne)
South Coast (Hosted by Hampshire Partnership Trust, led by Dr Clive
Holmes)
South West (Hosted by Avon and Wiltshire Mental Health Partnership NHS
Trust, led by Professor Roy Jones)
Thames Valley (Hosted by Oxford Radcliffe NHS Trust, led by Dr Rupert
McShane)
Dementias and Neurodegenerative Diseases Research Network Wales
Dementia Research Network Scotland (led by Dr Peter Connelly and
Professor John Starr, funded by the Chief Scientist Office, Scotland)
A Network within one City
In Australia
• The Cancer Research Network, established in
2006, is a cross-Faculty initiative of the
University of Sydney.
The Network has been established to link cancer
researchers in the University of Sydney and its
teaching hospitals and affiliated research
institutes and institutions, and thereby help build
high quality cancer research capacity and
achieve international cancer research
excellence in areas of strength.
University of Sydney
Cancer Research Network
• One of the main aims of the network is to
increase awareness of, and capacity for,
multidisciplinary collaboration across
groups. In the process, this will build a
sense of community among cancer
researchers across discipline and
geographical boundaries.
University of Sydney
Cancer Research Network
• The Network fosters communication with
and among members to facilitate research
collaboration, with an emphasis on
research translation. Translational
medicine, often known as bench to
bedside, focuses on moving research
discoveries from the laboratory into clinical
practice to diagnose and treat patients.
Research Networks
Enable researchers to share:
• Ideas
• Resources
• Patients and data
• Facilities
• Costs
• Overcome barriers
Thus leading to stronger research