Transcript CART for Rotary District 7570

The CART Fund
Coins for Alzheimer’s Research Trust
A project of Rotary Clubs of Southeast US
Rotary International District 7570
My Classmate Governor Byron (07-08) and lovely wife Kathy
Introduced by Assistant Governor Mary Miller
In Governor Byron’s
December 2007 Newsletter, this photo and caption appeared
together.
Youth Exchange from
page 1
Governor Elect Woody and First Lady Elect Lori
What we will cover today
• What is Alzheimer’s
disease?
• How does Alzheimer’s affect
the brain?
• What is CART?
• CART History
• Example CART Research
Grants
Alzheimer’s
Disease
What you need to
know
Alzheimer’s (AHLZ-high-merz)
disease is brain failure
-a progressive brain disorder that gradually destroys
brain cells and affects a person's memory,
ability to learn, make judgments, communicate,
and carry out basic daily activities.
Alzheimer’s is not normal aging.
It is a progressive, fatal disease, the cause
is unknown and it has no cure.
New meanings for familiar Words
* Sun-downing
* Wandering
*Elopement
Alzheimer’s Disease:
From Basic Research to Disease Cure
Sanjay W. Pimplikar
Cleveland Clinic
The CART Fund
Columbia, SC
May 7, 2008
What causes AD?
We do not know for sure!
Amyloid hypothesis
Alzheimer’s destroys brain
cells
There are 100 billion nerve
cells, or neurons, creating a
branching network.
Signals traveling through the
neuron forest form memories,
thoughts and feelings.
Alzheimer’s destroys
neurons, thus also destroying
memories, thoughts, impulse
control, personality, etc
Aβ
AD
AICD
Alzheimer’s causes the brain to shrink
(due to the death of neurons)
History of CART
.
In October 1995, the Sumter, S.C., Rotary
Club initiated the effort to prove CART works by
conducting an eight month testing program
which was highly successful
July 1996: District 7770 in South Carolina
adopted CART as a project.
April 1999: Our first grant of $100,000 is made to
Emory University's Alzheimer's Research Center under
the leadership of Dr. Allan Levey. AFAR (American Federation for
Aging Research).
History of CART
(cont)
.
In the 18 months from January 1999 until June 2000,
10 more Rotary districts of the Carolinas and Georgia
adopt CART as a project. The first Board of Directors
meeting was held in November 2000, bylaws were
adopted. They state that 100% of donated funds
must go to Research!!
Each district that joins the CART program has two
representatives on the board and two votes. The
District Chair and the DGN
Success to date: $3.5m
This is how we are related
History of CART Awards
1999 Emory University: Allan I. Levey, M.D. Ph.D. and
Jim Lau
2001 Case Western Reserve University: Karl Herrup,
Ph.D. and Gary Landreth
2003 University of Pennsylvania: John Q. Trojanowski,
M.D. Ph.D.
History of CART Awards
2006 University of Texas Medical Branch: Claudio
Soto, Ph.D.
2007 Mayo Clinic Jacksonville: Todd E. Golde, M.D.,
Ph.D.
2008 The Cleveland Clinic: Sanjay W. Pimplikar, Ph.D.
2009: Mayo Clinic, Jacksonville, Fl: Dr. Malcom
LeissringS, Ph.D.
History of CART Awards
2010 University of Kentucky: Paul Murphy, M.D.
$250,000
2010 University of Wisconsin-Madison:
Dr. Luigi Puglieli, Ph. D.
$150,000
2010 University of Pennsylvania:
Dr. Kurt Brunden, Ph.D.
$50,000
History of CART Awards
2011 University of Pennsylvania:
Dr. Kurt Brunden
$250,000
2011 Case Western:
Dr. Gary Landreth
$100,000
2011 Mass General
Dr. Brad Hyman $50,000
History of CART Awards
2012 Dr. Maya Koronyo-Hamaoui
Cedars Sinai, Oakland, CA.
$250,000
2012 University of Washington
Dr. Valarie Daggett, Ph. D.
$100,000
How devastating is AD on a
personal level. We lose contact
with the individual that we knew.
• How do we know what they are
thinking and feeling?
• How do they see themselves?
1996
2000
1999
1967
William Utermohlen: Self portraits
“..depict sadness, anxiety, resignation,
feeling of feebleness and shame.”
(NY Times, Oct 24, 2006)
1996
1998
1997
1997
You can help!! Lets find the cause,
and find the cure/prevention for this
dreaded disease!!