Transcript McNaughton et al (1996) J Exp Biol 199

HC Place cells
 taxi drivers enlarged
CA1 region
 Rat place cells
 How was this
diagram obtained?
 How reliable is it?
rat running in
triangular path
McNaughton et al (1996) J Exp Biol 199, 173–185
 Colours
represent
different
neurons
 recordings separated
by 1 hr in home cage
 recordings separated
by 6 hours of novel
environments
 The recording
environment consisted
of a moderately
illuminated room, with
a raised triangular
track located in the
middle. The rat’s task
was to move
continuously in one
direction around the
track to receive food
reinforcement at the
mid-point of each side
It all began…
400 ms
 Note this is actually a restrained rat, being
gently moved around
O'Keefe J, Dostrovsky J. Brain Res. 1971 Nov;34(1):171-5. [on VLE]
Multiple electrodes
Use a computer to do spike
recognition
O'Keefe &. Recce (1993) Hippocampus 3, 317–330
LEDs to track head
position and direction
Inbuilt FET amplifier, 14 x 4
Gothard et al (1996) J Neurosci: 16:823-835
Freely moving rat
O’Keefe (1976) Experimental neurol 51, 78-109 (1976)
Place unit 202-2. There is a smaller high-frequency displace unit in the background
O’Keefe (1976) Experimental neurol 51, 78-109 (1976)
trained to forage
in T-maze
light, buzzer,
fan, white
card,
O'Keefe Conway (1978) Exp. Brain Res. 31,573-590
place cells [2 and 3] firing as rat ran along runway
theta rhythm of EEG
speed of rat
O'Keefe &. Recce (1993) Hippocampus 3, 317–330
Precession
at end of rhythm
at start of rhythm
 rats foraging over
platform
 record CA1 pyramidal
cells in theta θ rhythm
Skaggs et al (1996) Hippocampus 6:149-172
Place cells fire out of θ phase
where was rat when θ was max?
Skaggs et al (1996) Hippocampus 6:149-172
where was the max firing of this
pyramidal cell?
Review
 Are the CA1 cells firing at random?
 Are the CA1 neurons firing to
 place
 some
other activity
 motivation?
http://biolpc22.york.ac.uk/750/mem/place_cells.ppt