Transcript Document

Remote memory
Hippocampus
Neocortex
Retrograde amnesia
Nongraded amnesia (Spatial memory tasks)
Multiple trace theory
methods
Physical studies
Pharmacological studies
Genetic lesion studies
Cellular and temporal precise
Optogenetics (Opsin Genes)
Specific Optogenetic Inhibition (OGI)of
Excitatory Neurons in Dorsal CA1 Reduces
Neuronal Activity
A temporally precise, stable and reversible manner
CA1 OGI Blocks Contextual Fear
Acquisition and Retrirval
A real-time involvement of CA1 excitatory cells, during acquisition and recall
No difference in exploration
Acquisition and expression of fear denpend on the amygdala
CA1 OGI Reversibly Interferes with Remote
Fear Memory Recall
Ongoing involvement, default activator of the memory trace
Disturb only recent but not remote
OPI limits expression of compensatory mechanisms
Precise but Not Prolonged CA1 OGI Blocks
Remote Contextual Fear Recall
Interrupted in the midst of a behavioral session
Hippocampus participate in remote memory trace maintenance
Brain-wide Mapping of Circuit Activity
Controlled by the Hippocampus during
Remote Recall
CA1 recruiting brain-wide fear memory activity
Increased activity compensating for hippocampal inactivation
OGI of Anterior Cingulate Cortex (ACC) Inhibits
Remote but Not Recent Contextual Memory
Olfactory bulbs (OB), no effect
Point not clear
This result at once demonstrates that a sudden
drop in a major source of synaptic input to
cortex need not nonspecifically influence recall
(without ruling out a contribution from such an
effect) and also points to the specificity of ACC
in remote memory (consistent with prior work).