Transcript The Link Between Stem Cells and Brain Tumors

Neural Stem Cells in
Treating Diseases of the
CNS
Brooke McCarthy
BME 281
Fall 2011
Stem Cells
Undifferentiated cells
Types
Cell division
Induced to become specialized cells
Physiologically
Experimentally
Neural Stem Cells
Most fundamental cell of the nervous system
Divides to create
Neurons
Astrocytes
Oligodendroglia
CNS
Malignant glioblastomas
Multiple sclerosis
Niemann-Pick’s disease
Current treatments
NSC Therapy
Inject
Migrate
Surround
Results
Multiple sclerosis
Niemann-Pick’s disease
Still too early
Pros
Best results
Injection
Either type of stem cell
Problems
Risks
BTSC
Mutation of NSC
Largest part of brain tumors
Resists treatments
Genetic engineering
Future
Genetic engineering
Cellular origins
Other diseases
Resources
Achanta, P. "Gliomagenesis and the Use of Neural
Stem Cells in
Brain Tumor Treatment." Anticancer Agents Med Chem.(2010):
121-30. Pubmed. Web. 17 Sept. 2011.
“Glioblastoma Multiforme.” Medscape. Web. 14 Sept. 2011. <http://
emedicine.medscape.com/article/283252-overview#showall>.
Taupin, P. "Potential of Neural Stem Cells for the Treatment of Brain
Tumors." Clinical Medicine: Oncology. (2008): 451-54. PubMed.
Web. 17 Sept. 2011.
“Stem Cell Information.” The National Institutes of Health. Web. 14
Sept. 2011. <http://stemcells.nih.gov/info/basics/basics1.asp>.
“What are Stem Cells?” Medical News Today. Web. 14 Sept. 2011.