Transcript Document

Amnesia
HM
- 1953 (27 y/o)
Bilateral medial temporal lobe damage
Assessment of Memory
Digit span + 1 - HM poor (8 - tops)
Block tapping - HM poor ( 5 taps)
Mirror Drawing - motor learning HM fine
Rotary Pursuit - motor learning
Incomplete pictures
Operant conditioning
Why two types?
Flexibility
Memento
QuickTime™ and a
Sorenson Video 3 decompressor
are needed to see this picture.
Amnesia & Dementia
Korsakoff’s Syndrome
- chronic alcoholism - thiamine (B1)
- medial diencephalon damage
Alzheimer’s Disease
- diffuse damage
- Ach in medial forebrain?
Concussion
Posttraumatic memory loss
- retrograde & anterograde - temporary
- electroconvulsive shock therapy - similar
- interfere with consolidation
Hebb Rule: if a synapse is repeatedly active at
the same time that the post synaptic neuron
fires, the synapse will be strengethened.
Hebb Synapse: a synapse that increases in
effectiveness because of simultaneous activity
in the presynaptic and postsynaptic neurons.
NMDA receptor - Glutamate
Inferior temporal (perirhinal) lesions disrupt this
Hippocampus lesions disrupt this
Delayed Non-matching-to-sample
- frontal lobe lesions disrupt
Frontal lobe important for remembering the task demands
object
space
The general arrangement of the pool.
In a place-learning task, a rat is put into the pool at various starting locations.
The animal must learn the location of a hidden platform, which can be done only
by considering the configuration of visual cues in the room-windows, wall decoration,
potted plants, and the like.
In a matching-to-place task, the rat is again put in the pool at random locations, but in
this case the hidden platforms is in a new location each test day. The animal must learn
that the location where it finds the platform on the first trial of each day is the location
of the platform for all that day’s trials.
In a landmark-learning task, the rat is required to ignore the room cues and to learn
that the cue on the wall of the pool signals the location of the platform.