Transcript Puberty - University of Wisconsin

Animal Science 434
Lecture 8: The Onset of Puberty
Development of
Hypothalamus and GnRH
Release Centers
Males and Females are Different!!!
Hypothalamus GnRH Control Centers
in the Female
Why does the male
only have tonic control
centers develop?
Male Brain Development
T
Testis
T
Surge Center
Does not
Develop
E2
Blood Brain
Barrier
Female Brain Development
E2
Placenta
E2
E2
E2
Ovary
Blood Brain
Barrier
Female Brain Development
aFP + E2
E2
Placenta
E2
E2
E2
Ovary
Surge Center
Develops
Blood Brain
Barrier
Fundamental Male and Female Differences
Pulse
Patterns
Surge + Tonic
Tonic
Puberty
The ability to accomplish
reproduction successfully.
Puberty in the Female
•
Age at first estrus (heat)
•
Age at first ovulation
•
Age at which the female can support
pregnancy
Puberty in the Male
•
Age when behavioral traits are expressed
•
Age at first ejaculation
•
Age when sperm first appear in the ejaculate
•
Age when sperm first appear in the urine
•
Age when the ejaculate contains a threshold
number of sperm
Average Age of Puberty (Range)
Species
Male
Female
Bovine
11 mo (7-18)
11 mo (9-24)
Ovine
7 mo (6-9)
7 mo (4-14)
Porcine
7 mo (5-8)
6 mo (5-7)
Equine
14 mo (10-24)
18 mo (12-19)
Human
13 yr
12 yr
Canine
9 mo (5 - 12)
12 mo (6 - 24)
Feline
9 mo (8 - 10)
8 mo (4 -12)
Genetic
Hormonal
Puberty
Environment
Nutritional
Hormonal
Role of GnRH Pulses
GnRH Pulses Determine Puberty
•
•
Prepubertal period
» minimal GnRH release
» FSH and LH low
» minimal to no folliculargenesis
or spermatogenesis
Puberty
» increase
in the pulse frequency and amplitude of
GnRH release
» increase in FSH and LH pulses
» folliculargenesis and spermatogenesis occur
Hormonal Changes in the Female
Changes in GnRH Secretion With Puberty
Surge
Tonic
Low Amplitude
and Frequency
Changes in GnRH Secretion With Puberty
Surge
Tonic
Changes in GnRH Secretion With Puberty
Surge
Tonic
Surge
Tonic
Surge
Tonic
Potential Regulators of GnRH Pulses
at Puberty
•
•
Development of surge center
Change in the feedback sensitivity to
estradiol
Development of
the
Hypothalamic
GnRH Surge
Center
Puberty =
28 - 30 weeks
Development of
the
Hypothalamic
GnRH Surge
Center
Puberty =
28 - 30 weeks
Positive
Feedback is
possible prior
to puberty
Changes in Feeback Sensitivity to Estradiol
Negative Feedback
Decreased Neg. Feedback
Puberty in the Female
Silent Ovulation at Puberty
Hormonal Changes in the Male
Puberty in the Stallion
Puberty
10
5
6
FSH
1
4
0.5
LH
2
T
0
0
0
0
20
40
60
Age (wk)
80 100
Testosterone (ng/ml)
15
LH
(ng/ml)
(ng/ml)
FSH
FSH
(ng/ml)
LH(ng/ml)
20
1.5
8
Testosterone (ng/ml)
25
15
10
5
0
LH
(ng/ml)
(ng/ml)
FSH
FSH
(ng/ml)
LH(ng/ml)
20
1.5
8
6
FSH
1
4
0.5
LH
2
T
0
0
0
20
40
60
Age (wk)
80 100
Testosterone (ng/ml)
25
Testosterone (ng/ml)
Increased Gonadotropins
Caused by
GnRH
10
5
0
6
FSH
1
4
0.5
LH
2
T
Testosterone (ng/ml)
15
LH
(ng/ml)
(ng/ml)
FSH
FSH
(ng/ml)
LH(ng/ml)
20
1.5
8
Testosterone (ng/ml)
25
0
0
0
20
• Sertoli cells mature and multiply
• Spermatogonia begin to divide
40
60
80 100
Age (wk)
Testosterone Remains Low
FSH Increases
Puberty
10
5
6
FSH
1
4
0.5
LH
2
T
0
Testosterone (ng/ml)
15
LH
(ng/ml)
(ng/ml)
FSH
FSH
(ng/ml)
LH(ng/ml)
20
1.5
8
Testosterone (ng/ml)
25
0
0
0
20
40
60
Testosterone Increases Age (wk)
80 100
Sperm found in
the ejaculate
Genetics
Influence of Breed on Age of Puberty
Species
Average Age at Puberty (Months)
Female
Male
Cattle
Holstein
Brown Swiss
Angus
Hereford
Brahman
8.5
11.6
12.4
13.0
19.0
9.0
8.8
9.8
10.8
17.0
3.1
6.3
7.0
3.0
5.8
6.5
Swine
Meishan
Large White
Yorkshire
Sheep
Rambouillet
Finish Landrace
9.2
8.6
Nutrition
Availability of Energy Changes with
Growth
Effect of 2-deoxyglucose on LH Pulses
GnRH
During 2DG
LH (ng/ml)
Before 2DG
3
2
1
0
1
2
3
4
5
6
7
Time (hours)
8
9
10 11
Effect of 2-deoxyglucose on LH Pulses
GnRH
During 2DG
LH (ng/ml)
Before 2DG
3
2
1
0
1
2
3
4
5
6
7
8
9
10 11
Time (hours)
Decreased Amplitude and
Frequency
Metabolic Signals Influence GnRH Neurons
Blood Glucose
Glucose sensing
neurons
?
Neuropeptide Y
neurons
GnRH
neurons
GnRH
Leptin
?
Adipocytes
(Fat)
Fatty Acid
sensing neurons
Blood Fatty Acids
Effect of Nutrition on Puberty
Body Weight (X 100 lbs.)
12
1.5 lb/day
2.0 lb/day
10
8
1.2 lb/day
6
4
2
0
0
4
8
12
16
Age (months)
20
24
% Mature Weight at Puberty
Dairy Cattle
30-40%
Beef cattle
55-65%
Sheep
40- 63%
Environmental and Social Conditions
Effect of the Number of Females
Housed Together
and
Exposure to A Male
32
Weeks
28
Weeks
24 Weeks
24 Weeks
Age at Puberty (days)
Influence of Growth Rate and Bull
Exposure on Age of Puberty
500
449
428
400
422
Moderate Growth Rate
High Growth Rate
375
300
200
100
0
Heifers
only
Bull
Exposure
Genetic
Hormonal
Puberty
Environment
Nutritional
Recommended Age to Breed
•
Heifer
15 months (65% mature BW)
• Bull
15 natural mating, 12 months AI
•
Filly
2-3 years
•
Colt
2 years
•
Boar
9 months