Transcript radiopharmaceutics lecture1

Course Content
1.Introduction
2. The
Atom
5-Biological
(Molecular and
Cellular) Effects of
Ionizing Radiation
3.Radioactive
decay
4-Interactions of
Radiation With
Matter
INTRODUCTION
Definition: Nuclear Pharmacy
Nuclear pharmacy is a specialty area of
pharmacy practice dedicated to the
compounding and dispensing of
radioactive materials for use in nuclear
medicine procedures (Diagnosis and
treatment).
Radioactivity
Character of certain atoms and therefore
in order to understand radioactivity we
must study the structure of the atom.
Introduction
All substances are made of atoms.
These have electrons (e) around the outside (negatively charged),
and nucleus in the middle.
The nucleus consists of protons (positively charged) and neutrons
(neutral), collectively called nucleons.
 Protons are positively charged with a mass 1800 times than of
electrons.
 Neutrons have the same mass like protons but carry no charge.
The atom
 All matter is made up of elements (e.g. carbon,
hydrogen, etc.).
 The smallest part of an element is called an
atom.
Atom of different elements contains different
numbers of protons.
 The mass of an atom is almost entirely due to the
number of protons and neutrons.
The Atom
The atom consists of two parts:
1. The nucleus which contains:
Protons
Neutrons
2. Orbiting electrons
For an atom of a given element, the number of electrons moving around the
nucleus equals the number of protons, balancing the electrical charge of the
nucleus.
 The electron configuration of the atom determines the
chemical properties of an element.
 The nuclear structure characterizes the stability and
radioactive decay of the nucleus of an atom.
The atom has a radius of approximately 10-8 cm, with the
nucleus having a radius of 10-12 cm.
1913
Electron configuration
Determines the
chemical properties
of an element
Nuclear structure
Characterizes the stability
and radioactive decay of
the nucleus of an atom
→ The mass M of a nucleus is always less than the combined masses of the nucleons A
in the nucleus.
→ This difference in mass (M-A) is termed the ‟mass defect”, which has been utilized
as energy in binding all the nucleons in the nucleus.
→ This energy is the ‟ binding energy” of the nucleus and needs to
be supplied to separate all nucleons completely from each other.
→ The binding energy of an individual nucleon has a definite value
depending upon the shell it occupies, it is approximately equal to
the total binding energy divided by the number of nucleons.
→ This energy is about 6 to 9 MeV and has to be supplied to remove
a single nucleon from the nucleus.
Structure of the nucleus
Mass number = number of protons + number of neutrons
A
Elemental atom
X
Z
N
Atomic number = number of protons
Neutron number
Electronic structure of the
Atom
 The electrons are located in discrete energy orbits or shells around
the nucleus (Bohr atomic theory).
 These energy shells, referred to as the K shell, L shell, N shell, etc.,
are stationary and arranged in order of increasing energy.
 Each orbit has a limited capacity to hold only a definite number of
electrons. That K contains 2 electrons, L contains 8 electrons.
► Each shell is designated by quantum number n, called the
principal quantum number.
► Each energy shell is subdivided into subshells or orbitals, which
are designated as s, p, d, f, etc. (azimuthal quantum numbers, l).
l = 0,1,2……etc.
► The electron will enter the orbital of the lowest energy first and
the next higher energy orbital is then filled.
For example: 11Na
1s2 2s2 2p6 3s1
BOHR ATOM
electrons:
n = principal
quantum number
1
2
n=3
Nucleus: Z = # protons
= 1 for hydrogen to 94 for plutonium
N = # neutrons
Atomic mass A ≈ Z + N
n labels shells; shells are composed of sub-shells: s, p, d, f, …
Electronic Structure of the Atom
Each energy shell is
subdivided
into
subshells (I=n-1) or
orbitals, which are
designated as s, p, d,
f, and so forth.
Magnetic quantum number(m)
m (No. of orbitals)= 2 I+1
Where : values of I = 0,1,2,3,4 for
the subshells s,p,d,f,g
respectively.
Electronic Structure of the Atom
The total number of electrons in a given
shell is 2n2.
Thus, the K shell can contain only two
electrons, the next L shell eight electrons,
the M shell l8 electrons, the N shell 32
electrons, and the O shell 50 electrons.
In atoms, the orbitals are filled in order of
increasing energy; that is, the lowest
energy orbital is filled in first.
Examples of the electron configurations
of some elements are given below:
11Na
1s22s22p63s1
18Ar
1s22s22p63s23p6
22s22p63s23p63d64s2
Fe
1s
26
43Tc
1s22s22p63s23p63d104s24p64d65s1 Technetium
49In
1s22s22p63s23p63d104s24p64d 105s25p1
Indium
The periodic table
 The periodic table is a chemistry reference.
 Elements are arranged left to right and top to bottom in order of
increasing atomic number.
 This order usually coincides with increasing atomic mass.
 The different rows of elements are called periods. Elements of each row have
the same number of energy levels (shells) but dissimilar chemical properties.
The period number of an element signifies the highest energy level an
electron in that element occupies.
 The different columns of elements are called groups. Elements in the same
group have similar chemical properties.
Describe the Periodic Table
Atomic Mass:
The atomic mass is the average mass of an element in atomic mass units ("amu").
Models for the arrangement of nucleons in a nucleus
1. Bohr liquid drop theory: The nucleus is assumed to be spherical
and composed of closely packed nucleons, and particle emission by
the nucleus resembles evaporation of molecules from a liquid drop.
2. In the shell model, nucleons are arranged in discrete energy shells
similar to the electron shells of the atom in the Bohr atomic theory.
Nuclei containing 2, 8, 20, 50, 82 or 126 protons or neutrons are very
stable and the nucleon numbers are called magic numbers.
3. Nuclei are less stable if they contain an odd number of protons or
neutrons, whereas nuclei with even numbers of protons and neutrons
are more stable.
 The stability of the atom depends on the neutrons to
protons ratio (N/Z) ratio in the nucleus.
 This ratio equals 1 in the stable nuclei with a low atomic
number, such as 126C, 168O and 147N, and the ratio increases
with increasing the atomic number of the nucleus.
For example, this ratio is 1.40 for 12753I.
Electrons distribution
Valence electrons:
H N H
H
●● Electrons in the highest (outer) electron shell.
●● Have most contact with other atoms.
●● They are distributed as shared or bond pairs and unshared or lone
pairs.
Octet Rule:
● All chemical bond formation is governed by the octet rule that the
electronic structure of each atom in a chemical bond containing 8
electrons.
● An octet in the outer shell makes atoms stable.
● Electrons are lost, gained or shared to form an octet.
● Metals lose electrons to match the number of valence electrons of
their nearest noble gas e.g. He [2], neon [2,8]
Octet Rule = atoms tend to gain, lose or share electrons so
as to have 8 electrons
Chemical bonds: an attempt to fill electron shells
1. Ionic bonds
2. Covalent bonds
3. Covalent coordinate
1. IONIC BOND
- bond formed between two ions by the transfer of electrons.
- Ionic compounds result when metals react with nonmetals.
- Produce charged ions all states. Conductors and have high
melting point.
Examples; NaCl, CaCl2
Ionic bond – electron from Na is transferred to Cl, this causes
a charge imbalance in each atom. The Na becomes (Na+)
and the Cl becomes (Cl-), charged particles or ions.
2. COVALENT BOND
- Bond formed by the sharing of electrons. It means that each
of the atoms participating in bond formation contributes one
electron to the bond.
- The shared electrons are localized in the region between the
two atoms and unlike to the ionic bonds, do not belong
exclusively to one atom alone.
- Stable non-ionizing molecules, they are not conductors at
any state. Examples; O2, CO2, C2H6, H2O
Covalent bonds: Two atoms share one or more pairs of outer-shell
electrons.
A. Non-Polar covalent bond
When electrons are shared equally, for example H2 or Cl2
B. Polar covalent bond
when electrons are shared but shared unequally, for example Hcl, H2O
- water is a polar molecule because oxygen is more
electronegative than hydrogen, and therefore electrons
are pulled closer to oxygen.
3. Coordinate covalent bond
The pair of electrons required for bond formation is donated by only one
atom to another that can accommodate two electrons in octet formation.
Nitrogen and oxygen atoms have donated their lone pair of
electrons to a hydrogen bond.
In a coordination complex:
an arrow is used to show the bonding interaction of an electron
pair from a neutral ligand to an acceptor central atom.
[Co(H2O)6]2+ + 6 NH3 -----> [Co(NH3)6]2+ + 6 H2O
Ligand or complexing agent
2+
NH3
H3N
NH3
Co
NH3
H3N
Metal ion
Donation of unshared pair of electrons
NH3
Ethylene Diamine Tetraacetic Acid (EDTA)
Chelating agent
● Single ligand molecule can possess more than one donor atom and
can donate more than one pair of electrons in the complex.
● In such cases, more than one coordinate covalent bond is formed in
the complex. The mechanism of bond formation is called chelation.