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Canine brucellosis Definition It is an infectious diseases of dog caused by B. canis, characterized by abortion and epididymitis Etiology B. canis is gram negative coccobacilli Dog also susceptible to infection with B. abortus Epidemiology Distribution Animal susceptible The disease present in certain locality and present in Egypt Dogs of all ages and sex Mode of transmission Source of infection: vaginal discharge, aborted fetus and urine of infected or carrier animals Mode of transmission: Contact through oronasal (ingestion or inhalation) Penetration of conjunctiva of genital mm Venereal or AI through infected semen Pathogenesis Following infection bacteremia Localized in Lymphoid tissues within macrophages Transport to genital organs Orchitis, epididymitis and abortion infertility Clinical signs Fever, lethargy and poor reproductive performance In male: Scrotal swelling due to epididymitis and infertility In female: Early embryonic death Late gestation abortion at 45-59 days Persistent brown to greenish vaginal discharges for 6 w after abortion Early fetal resorption Diagnosis Field diagnosis The clinicians suspect the disease from clinical signs of abortion, epididymitis and epidemiology of the disease Laboratory diagnosis Samples Placenta, vaginal discharge, aborted fetus, blood and serum Laboratory procedures Direct microscopic examination with gram stain Isolation on specific media Serological test: It gives negative results within 4 w after abortion or infection False positive result due to cross reaction with other bacteria Treatment It is expensive and usually unsuccessful in late stage Antibiotic as dihydrostreptomycin 10 mg/kg every 12h for 1 w alone or with doxycycline 5-10 mg/kg orally every 12 h Control Isolation of infected animals Hygienic disposal of aborted fetuses and fetal placenta Testing all breeding stock before entry in breeding Cleaning and disinfection all infected premises and equipment