Transcript 2012-07-10 Discussion Sanford-Burnham Medical Institute Update

Sanford-Burnham Update
Orlando’s Developing Life Sciences Initiative
Daniel P. Kelly, M.D.
Scientific Director
July 10, 2012
Sanford-Burnham Medical Research Institute
La Jolla
Est. 1976
Orlando
Est. 2007
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Not-for-profit research
Cancer, neurologic, infectious and childhood disease, diabetes and obesity
# 3 among research institutes in NIH funding
# 1 worldwide ranking: citation of Sanford-Burnham studies in biology and
biochemistry journals
• First Medical City facility to open (April 2009)
• 175,000 sq ft facility
• Largest GOLD LEED independent scientific
facility in Florida
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Medical City at Lake Nona
Nemours Children’s Hospital
VA Medical
Center
UCF College
of Medicine
Sanford-Burnham
University of Florida
Research Center
4
Sanford-Burnham Medical Research Institute
Infectious &
Inflammatory
Disease
Center
Cancer
Center
Sanford Child
Health Center
Metabolism
CV Pathobiology
Translational Research
Neuroscience,
Aging and Stem
Cell Center
Diabetes &
Obesity
Center
Florida Campus Focus: High-Impact,
Disease-Oriented Research
• Early drug discovery
Metabolic origins of:
 Pharmaceutical
• Diabetes
experience
• Obesity
 Biotech business
• Heart and vascular diseases
development expertise
• Cancer
• Diagnostic biomarker
discovery
 Genomics
 Metabolomics
Why Obesity and Diabetes?
•
Obesity contributes to a
variety of chronic diseases
•
Obesity is driving a dramatic
expansion of Type 2 diabetes
– major cause of death in U.S.
•
Spreading to pediatric age
groups: Super-sized kids may
have shorter life expectancy
than parents
Obesity Trends Among U.S. Adults
1990
1999
2009
No Data
<10%
10%–14%
15%–19%
20%–24%
25%–29%
≥30%
Diabetes is a Lethal Disease
•
Cardiovascular
disease is the
leading cause of
death
•
The prognosis is
grim for diabetics
following heart
attack
•
Cardiovascular
disease in diabetics
is unique, and
refractory to
current Rx
Diabetes
Cancer
CV Disease
Stroke
National Center for Health Statistics, 1998
Our Research Pursuits:
Interdisciplinary, Collaborative, Disease-oriented
Cardiovascular
Disease
Diabetic
CV
Disease
Obesity
Diabetes
Accomplishments to Date
•
2/3 of the way towards reaching our
faculty recruitment goal of 29
•
Over half way towards meeting our
2016 employment goal of 300
positions
•
Created high-value jobs, paying 130
percent average private sector wage
in Orange County
Sanford-Burnham at Lake Nona Faculty:
Recruitment by Site of Origin
Kelly
Han
Wash. Univ.
Ayala
Vanderbilt
F. Rastinejad
S. Khorasanizadeh
Univ. of Virginia
Roth
Abbott
Pratley
U Vermont
Jiang
U Mass.
Wood
Univ. of Alabama
Gulick
MGH
Osborne
Gardell
UC Irvine
Wyeth
Collins
Hamner
Altarejos
Salk
Perera
Savannah
Sikder
UTSW
S. Smith
Pennington
L. Smith
Vanderbilt;
Scripps
Accomplishments to Date
•
Received over $52 million in research grants
•
Published over 130 scientific papers
•
Written 155 contracts (MTAs, CDAs, RCAs, etc.)
•
Completed 13 patents and 21 invention
disclosures (potential patents)
•
Brought multiple pharmaceutical companies to
Orlando to consider partnerships
We are Diversifying Our Revenue Streams
•
The percentage of total
research dollars from outside of
Florida has risen from 40% to
50% in one year ( 2010 – 2011)
•
Launched commercial research
partnership with Takeda Co. and
Florida Hospital, bringing
revenue and attracting
international industry attention
to region
•
Sanford-Burnham has
successfully secured
commercial research funding
with Thermo Fisher, Eli Lilly and
Novo Nordisk…others in
negotiation
Florida Translational Research Fund
• State of Florida approved recurring $3MM to fund collaborative
research with universities and non-profit institutes throughout
Florida
• The program provides scientists statewide with access to SanfordBurnham’s state-of-the-art technologies for drug discovery
• Leverages the government’s
(state and local) prior investment
State-of-the-Art Technologies
Enable Research and Drug Discovery
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Robots screen a “library” of
compounds to discover
small chemical structures
that are the leads for the
drugs of tomorrow
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1 of 4 NIH Comprehensive
Screening Centers in U.S.
•
Leverage technology to
attract additional grants
In 2011, scientists successfully synthesized more than 500 new chemical
compounds and identified 12 novel probes (early drug candidates).
Contributing to Local Growth and Job Creation
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Sanford-Burnham’s presence in Lake Nona and desire to
collaborate helps area institutions attract top doctors and
medical researchers
“Our location in Lake Nona’s Medical City and proximity to
Sanford-Burnham has been enormously helpful as Nemours
recruits world-class physician-researchers.”
Dr. Lane Donnelly, Chief Medical Officer, Nemours Children’s
Hospital
“Sanford-Burnham was a catalyst in the formation of the
Translational Research Institute at Florida Hospital.”
Lars Houmann, President and CEO, Florida Hospital
Growth of State of Florida Biotech Industry
•
Florida’s biotechnology industry has grown by 42 percent over the past five
years
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Nearly 200 biotechnology companies operate in Florida
•
65 percent increase in life science venture dollars in Q1 2012 over Q4 2011
Florida researchers were awarded 2.3% of NIH money in 2012, up from 1.5% in 2006
Training Tomorrow’s Scientists in Orange County
Inspiring a passion for science:
• Rigorous postdoctoral
training
• United Negro College Fund –
Sanford-Burnham four year
scholarship
• Contribute to science
curriculum in local schools
• Lab clinics for teachers
• Career days for college and
high school students
• Internships and summer
camps
Bridging the Translational Divide
Discovery
Improving Patient Care
Towards Personalized Medicine
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Clinical Partnerships Test
Therapeutic Potential of Discoveries
Bench to Bedside
Basic
Research
Bedside to Bench
Steven R. Smith, M.D.
Clinical
Research
Translational Research Institute
for Metabolism and Diabetes (TRI)
Florida Hospital/Sanford-Burnham
Research Discovery and Validation in Humans
First-in-human trials
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The BRAIN-FAT Connection!
Orexin
Dr. Dev Sikder
The HEART-FAT Connection!
ANP
Dr. Sheila Collins
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Emerging Translational Research Partnerships
Regional
Health Systems
Pharma
Translational
Research
Institute
(Florida Hospital)
Sanford-Burnham
Academic Centers
UCF
VAMC
Nemours
Sanford-Burnham
Duke
UF
Wash U
Sanford-Burnham
Collaborative Regional Partnerships
Advance Science
Joint Research  Sharing Technologies  Teaching and Training
Sanford-Burnham wishes to express
special thanks to Orange County for
your support and partnership
Sources of Sanford-Burnham Grant Revenue
DoD
$1 million
2%
Industry
$3 million
6%
Non Fed
$3.8 million
7%
NIH
$44.2 million
85%
Grant Revenue by Fiscal Year
$14,000,000
$12.1 M
$10.5 M
$10.6 M
$12,000,000
$9.9 M
$10,000,000
$6.8 M
$8,000,000
$6,000,000
$4,000,000
$2.2 M
$2,000,000
$0
2008
2009
2010
SBMRI-LN
2011
Bi-Coastal
2012
2013+
Proposals/Awards
120
100
Proposals
80
60
40
20
0
Submitted
Awarded
Still Pending
FY08
14
6
0
FY09
30
6
0
FY10
55
18
0
FY11
76
18
0
FY12 To Date
101
7
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Recruitment Progress and Timeline for SBMRI - Fla
Burnham Lake
Nona
Opens temporary
labs at FBC,
Orlando
Burnham
announces
plans to expand
to Orlando, FL
2006
Sanford gift: renamed to
Sanford-Burnham Medical
Research Institute at Lake
Nona (1/10)
2007
. Faculty numbers:
1
New facility opens 4/09
2008
2 3
4
2009
56
8
9 11
Dan Kelly assumes
Scientific Director
Position; DOC
established (7/08)
2011
2010
13
Goal
15
17 18
19
28-30 (2016)
One contract not renewed
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