Transcript Dia 0 - Podcast Producer

The University of Antwerp
Faculty of Medicine
University Hospital Antwerp
K. Van Liempt
Faculty of Medicine
0
The Antwerp Region
• 470.000 people in the City of Antwerp
• Most important economic region in Flanders
• Strong economic assets:
-
Port of Antwerp 2nd largest in Europe; 4th world-wide
Largest cluster of petrochemical industry in the world
Diamond trade
Logistics
1
The University of Antwerp
• Founded in 2003 upon the merger of three
independent University Institutions
UIA
RUCA
UFSIA
• Roots dating back to 1852
2
The University of Antwerp in Flanders
3
The University of Antwerp in the World
• University Rankings
- QS World University ranking : 179
worldwide
- ARWU (“Shanghai”) : 201-300 worldwide
• Consistently in the top 250 worldwide
4
Facts and Figures
• Main partner in the Antwerp University Association
- 1 university (UA)
- 4 university colleges
•
•
•
•
30 000 students in total
400 FTE UA-faculty staff
1200 UA-research staff
1100 UA-PhD students
• Around 3500 scientific works published/year
- 1500 articles in Web of Science/year
5
Organisational Structure
Humanities and
Social Sciences
Applied Economics
Arts and Philosophy
Law
Political and
Social Sciences
Life Sciences
Pharmaceutical,
Biomedical and
Veterinary Sciences
Natural Sciences
Sciences
Medicine
7 Faculties
6
Front Line Research Domains
Harbour, Transport
and Logistics
Social Economic
Policy and
Organisation
Imaging
Urban History and
Contemporary
Urban Policy
Ecology and
Sustainable
Development
Materials
Characterisation
Neurosciences
Infectious Diseases
Drug Discovery
and Development
7
Front Line Research Domains
Harbour, Transport
and Logistics
Social Economic
Policy and
Organisation
Imaging
Urban History and
Contemporary
Urban Policy
Ecology and
Sustainable
Development
Materials
Characterisation
Neurosciences
Infectious Diseases
Drug Discovery
and Development
8
Imaging
• EGAMI: Expert Group Antwerp Molecular
Imaging
- Network of research labs
•
•
•
•
•
Biomedical Microscopic Imaging
Bioimaging Lab
Molecular Imaging Center Antwerp (MICA)
MicroCT Lab
Vision Lab
- Links with Antwerp University Hospital (UZA)
• Radiology
• Nuclear Medicine
9
Imaging
Molecular and
Cellular Imaging
Small Animal
Imaging
Light Microscopy
μMRI
MRI
(Scanning) Electron
Microscopy
μPET
PET/SPECT
Fluorescence
Microscopy
μCT
CT
In Vivo Bioluminescence and
Fluorescence
Camera
Image
Processing
Confocal Microscopy
Confocal Live Cell
Imaging
Electrophysiology
Advanced Immunohistochemistry
Clinical Imaging
Image Processing
10
Imaging
11
Imaging - Highlight
• Molecular Imaging Center Antwerp
(MICA)
- Partnership between UA – UZA – Janssen
Pharmaceutica
• Cyclotron + μPET/CT: micro-radiotherapy (320 keV),
autoradiography, direct access to FDG, FLT, FET and
possibility to produce research tracers, kinetic modeling,
multimodal image registration
- Fully operational spring 2011
12
Front Line Research Domains
Harbour, Transport
and Logistics
Social Economic
Policy and
Organisation
Imaging
Urban History and
Contemporary
Urban Policy
Ecology and
Sustainable
Development
Materials
Characterisation
Neurosciences
Infectious Diseases
Drug Discovery
and Development
13
Neurosciences
Neuronal
Degeneration
Neurogenetics
Neurobiology
Neuropathology
Biobank/
Biomarkers
Neuronal
Plasticity
Neuronal Repair/
Replacement
Cognition and
Behaviour
Stem Cells
Stem Cells
Neurogenetics
Song Birds
Neuronal
Tissue
Engineering
Rodent Models
Nanotechnology
Psychiatric
Disorders/
Dementia
14
Neurosciences
in vivo
+30 mV
-80 mV
ex vivo /
in vitro
< cell
cell
tissue
organism
15
Neurosciences - Highlight
• VIB Department of Molecular Genetics (VIB8)
(Director: Prof. Dr. Christine Van Broeckhoven)
- Genetic analysis of complex neurological and
neuropsychiatric diseases
• To identify novel molecular mechanisms for disease causation
and effective drug treatment for these diseases
- 4 research groups
•
•
•
•
Neurodegenerative Brain Diseases
Peripheral Neuropathies
Neurogenetics
Applied Molecular Genomics
- 2 centralized service facilities
• Diagnostic Service Facility
• Genetic Service Facility
16
Front Line Research Domains
Harbour, Transport
and Logistics
Social Economic
Policy and
Organisation
Imaging
Urban History and
Contemporary
Urban Policy
Ecology and
Sustainable
Development
Materials
Characterisation
Neurosciences
Infectious Diseases
Drug Discovery
and Development
17
Infectious Diseases
• Multidisciplinary research on infectious
diseases and vaccines
- Focused on microbiology and immunology, with
contributions of other disciplines
•
•
•
•
Epidemiology
Statistics/Mathematical modeling
Sociology
Economics
18
Infectious Diseases
Basic Research
Preclinical
Research
Clinical
Research
Immune
System
Biomarkers
Diagnostic
Tests
Disease
Mechanisms
Vaccines
Vaccines
Antibiotic
Resistance
Injection
Devices
Prevention
Epidemiology
19
Infectious Diseases - Highlights
• Antibiotic use and resistance
- European Surveillance of Antimicrobial
Consumption (ESAC)
• European project coordinated by Prof. Dr. Herman
Goossens of the UA
- Funded by the European Centre for Disease Prevention and
Control (ECDC)
- 34 participating countries
• Study of the use of antibiotics, antivirals and antimycotics
and occurrence of resistance
• A vaccine against leukemia?
- Wilms’ tumor 1 antigen-targeted dendritic cell
vaccination against acute myeloid leukemia
• Van Tendeloo et al., PNAS, 2010
20
Front Line Research Domains
Harbour, Transport
and Logistics
Social Economic
Policy and
Organisation
Imaging
Urban History and
Contemporary
Urban Policy
Ecology and
Sustainable
Development
Materials
Characterisation
Neurosciences
Infectious Diseases
Drug Discovery
and Development
21
Drug Discovery and Development
Preclinical
Drug
Development
Target
Discovery
Drug
Discovery
Disease
Pathology
Medicinal
Chemistry
Biomarkers
Disease
Mechanism
Small
Molecules
Toxicity
Animal
Models
In vitro
Screens
Imaging
End point:
Clinical Trials
Medicinal
Plants
22
Drug Discovery and Development
• Major Focus of Disease Areas:
- Bone disease
• Osteoporosis
- Cancer
- Cardiovascular disease
• Atherosclerosis
- Infectious disease
• Bacterial, fungal and parasitic infections
- Kidney disease
- Metabolic disease
• Diabetes
23
Drug Discovery and
Development - Highlight
• Antwerp Drug Discovery Network
- Integrated Platform for early drug discovery from
hit to lead optimisation
- Protease Inhibitors
• Urokinase Plasminogen Activator (uPA) inhibitors in
Oncology
• Molecular Probes as drug discovery tools
- Infectious Diseases
• In vitro screening panels for antifungals
and drugs against tropical diseases
• Reference Center World Health Organization
(WHO)
24
Faculty of Medicine
• Overview number of students
-
Medecine BA-MA
Nursing MA
Specialisation
Doctoral School
Physiotherapy
- Total
750
194
250
210
520
1924
25
Faculty of Medicine
• Features of medical education
- BA / MA structure
- Competence driven and student
oriented teaching
- Integration of CANMEDS roles in the
curriculum aimed at transforming
students into medical experts
- English semester, Spring, 4th year
26
University Hospital Antwerp
• Features of University Hospital
- 600 beds
- 520.000 consultations and technical
activities
- 300 MIO € yearly budget
- Legally independent from University,
but connected with several links,
especially with the faculty of medicine
- Close collaboration with regional
hospitals
27