Transcript Biofunctional imaging and image guided therapies for Neuroscience

Center for Translational Neuroscience
Seminar Series
BIOFUNCTIONAL IMAGING AND IMAGE GUIDED
THERAPIES FOR NEUROSCIENCE
Rayford Auditorium, BioMed II Bldg.
Tuesday, September 4, 12 noon
Michael J. Borrelli, Ph.D.
Director of Radiology Research
PET/CT
DTI
MRI
Molecular imaging modalities like PET/CT and MRI spectroscopy (MRS),
and other biofunctional imaging techniques like functional MRI (fMRI) and
diffusion tensor imaging (DTI), can be used repeatedly to non-invasively
obtain quantitative information about neurological activity, biochemistry, and
physiology. Such biofunctional imaging data can be fused with high
resolution morphological CT, MRI and Ultrasound images to link structure
with function for both normal and diseased tissues. These imaging
techniques and many of their applications will be presented and discussed.
These modalities can be used to image and quantify the delivery and efficacy
of therapeutic treatments and agents throughout a treatment regime . Clinically relevant information can be obtained that can help personalize treatments
for each individual patient, e.g. by indicating which patients are responding
well or poorly. The latter can be treated more aggressively or moved on to
another treatment regime that might prove more effective.
Non-invasive imaging also permits obtaining information during longer,
longitudinal studies with the same animals, which will improve developmental
studies, help reduce experimental variability, and reduce the number of
animals needed for many studies. Invasive measurements and periodic
biopsies can be used to confirm the results of the imaging procedures, which
will help define the usefulness and value of these imaging modalities.