Transcript Presentation - National Academies

The Institutional Development Award (IDeA) Program
W. Fred Taylor, PH.D.
National Institute of General Medical Science
National Institutes of Health
May 25, 2012
• Program Overview
• Centers of Biomedical Excellence (COBRE)
• Phase I, Phase II, Phase III
• IDeA Clinical and Translational Research (IDeA CTR)
• IDeA Networks of Biomedical Research Excellence
(INBRE)
• IDeA Community-Based Research
• Selected Examples
• IDeA Co-funding
• IDeA Net
• Selected Examples
• National Association of IDeA Principal Investigators
(NAIPI)
• Selected Science Advances
Program Overview
Institutional Development Award Program
•
Authorized by Congress, 1993 NIH Revitalization Act
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Intent to enhance geographical distribution of NIH
research funds and increase research capacity
•
Currently 23 states and Puerto Rico are IDeA eligible
•
Similar to NSF Experimental Program to Stimulate
Competitiveness in Research (EPSCoR, est. 1980)
•
Contact:
W. Fred Taylor, Ph.D.
[email protected]
Institutional Development Award Program
Perceived needs to increase research capacity:
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Core Laboratories
Senior and Junior Faculty development
Infrastructure (equipment)
Facilities alteration and renovation/development
Post-doctoral, student and staff development
Faculty recruitment
Bioinformatics training for students and faculty
“State of the Art” Instrumentation
Release time for teaching and clinical faculty
Undergraduate, graduate, post-doctoral recruitment
Training opportunities in grant management
Institutional Development Award Program
Overall Approach
Faculty development
• Faculty recruitment and start-up
• Funding and release time for research projects
• Mentoring to become successful independent
investigators
Enhancement of research facilities
• Core laboratories
• State-of-the-art equipment
Research education and training
• Graduate students, postdoctoral fellows, research staff
• Undergraduate students and faculty
INBRE: 24 statewide networks
COBRE: 84 thematic research centers
VT
MT
ME
ND
NH
ID
SD
RI
WY
NE
NV
DE
WV
KS
KY
OK
NM
SC
AR
MS
LA
AK
HI
PR
Centers of Biomedical Excellence (COBRE)
Phase I, Phase II, Phase III
Centers of Biomedical Research Excellence (COBRE)
Background
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COBRE center grant program launched in fiscal year 2000
•
To expand and develop biomedical faculty research capability
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To enhance research infrastructure including core facilities
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To build multidisciplinary research centers with a thematic scientific
focus at doctoral institutions or research institutes
Center Characteristics
• Led by an established investigator, funded by NIH, NSF or other
comparable Federal or private sector source
• At least 3 research sub-projects, all supervised by junior investigators
• A clear plan for mentoring, career development and graduation and
replacement of junior investigators
• Long-term plans for developing and sustaining the center,
investigators, collaborations, and physical infrastructure
Model of COBRE
Pilot
Projects
research
cores
External
Advisory
Board
bioinformatics
administrative
Administrative
and Research
Cores
•workshops
•training courses
Mentored
Junior Investigator
Subprojects
Mentors
COBRE
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Currently three sequential 5 year phases
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Phase I: To develop research infrastructure and provide
junior (new) investigators mentoring and project funding so
they can successfully compete for independent research
support
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Phase II: To further develop research infrastructure and
develop a strong critical mass of investigators (new, early
stage and established) with shared scientific interests
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Phase III: To maintain COBRE research cores and to provide
support for research pilot projects and mentoring and
training
Develop advanced research infrastructure and a
critical mass of investigators in thematic areas
Research
Infrastructure
Research Projects
(Junior Investigators)
Research
Infrastructure
Research Projects
(Junior and Senior
Investigators)
Research Cores
that are essential
for basic and
clinical research
Pilot Project
Program
Centers of Biomedical Research Excellence (COBRE)
Phase III: Transitional Centers
Purpose
• To conduct basic, clinical and translational research
• To support essential cores
• To sustain a collaborative, multidisciplinary research
environment by supporting mentoring and training
components.
Center Characteristics
• Administrative Core (mentoring and training components and
pilot projects)
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Core resources including core supplies, service contracts and
core management
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Equipment upgrades and replacement
Summary of COBRE Scientific Themes
Scientific
Themes
Number
of
Grants
Neuroscience
Cancer
Cardiovascular
Disease
Immunology
Proteomics
and
Genomics
Infectious Disease
Oral Health
Women or Minority
Health and Health
Disparity (WMHHD)
Environmental
Science (ES)
Muscle
Biology
(MB)
Biochemistry and
Biophysics (BB)
Drug
Discovery
and Design (DD)
Lung Biology and
Disease (LD)
Prenatal
Biology
(PB)
Stem Cell Biology
(SCB)
Bioengineering
and Biomaterial
18
9
11
9
8
5
5
MB
BB
DD LD
PB
SCB
ES
WMHHD
Oral
Health
4
2
3
2
3
2
2
3
1
Infectious
Disease
Proteomics and
Genomic
Immunology
COBRE Progress
In fiscal year 2011:
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84 COBRE awards supported 786 research
projects involving 1482 investigators
COBRE centers published 1449 articles with an
additional 603 papers in press
COBRE investigators made a total of 1882
scientific presentations
IDeA Clinical and Translational Research
(IDeA CTR)
IDeA Program Clinical and Translational Research Initiative
(IDeA CTR)
Rationale:
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A relatively small proportion (~10%) of IDeA-funded
centers and networks focus on developing clinical and
community-based translational research capacity
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It is critically important to translate the many
biomedical research advances from IDeA states into
better health outcomes by forging partnerships
between basic and clinical scientists in IDeA
institutions, supported by programs across NIH
IDeA-CTR
Objectives:
•To support the development of infrastructure and human
resources required to conduct clinical and translational
research in IDeA states.
•To enhance the ability of IDeA institutions and investigators
to develop competitive clinical and translational research
programs.
•To foster and sustain collaboration and coordination of
clinical and translational activities within and across IDeA
institutions /organizations.
IDeA-CTR
Award mechanism and Total Cost
• U54 cooperative agreement
• Up to $4 million per year for 5 years
• Can request additional $300K for A&R costs (year 1 only)
Lead Institution
• Academic Health Center
• Only one application per state
Partnerships
• It is required to identify one or more collaborating domestic
partner(s) within the state and in one other (or more) IDeA
state(s).
Funding Opportunity Announcement: IDeA-CTR (PAR-11-229)
Component Activities of IDeA-CTR Program
Recruitment of
Clinical/
Translational
Faculty
Community
Engagement and
Outreach
Partnerships and
Collaborations
within and across
IDeA-eligible
states
Clinical and
Clinical Research
Translational Pilot
Design, Epidemiology,
Grants Program
and Biostatistics Core
Clinical Research
Resources and
Facilities
Clinical Research
Education, Mentoring,
and Career
Development Core
Potential Key Component Activities
Biomedical
Informatics
Resources
Ethics,
Regulatory
Knowledge and
Other
Technologies and
Resources for
Core Laboratories
IDeA Networks of Biomedical Research
Excellence
(INBRE)
IDeA Networks of Biomedical Research Excellence
(INBRE)
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To develop a statewide multi-disciplinary research network of doctoral
degree-granting and undergraduate institutions
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To build and increase research capacity by supporting faculty, fellows and
students at participating institutions
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To provide bioinformatics tools, training, and expertise for researchers and
students across the network
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To provide undergraduate faculty and students research support, serve as
“pipeline” to health research careers
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To provide outreach to students at undergraduate institutions, community
colleges and tribal colleges
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To enhance statewide science and technology knowledge base
Model of INBRE
PUI
PUI
PI PC
Other Cores
Bioinfor. Core
Outreach
Institutions
Tribal/Community
Colleges
Outreach
Core
Admin. Core
PUI
PUI
Lead InstitutionResearch Intensive
Institutions or Institutes
PUI
PUI = Primarily Undergraduate Institution
KANSAS-INBRE Organization
SSC
Hays
Wichita
State Univ.
Pittsburg
Kansas
State Univ.
Haskell
Outreach ICs
K-INBRE
Emporia
Lead IC
Langston
Washburn
Kansas Univ.
Lawrence
Bioinformatics
Cores
•Data analysis of
genomics, proteomics
and lipidomics
•Data storage and web
access
Building new strengths in Cell and Developmental Biology
in the state of KS thereby paving new strategies to improve
human health
•Trans-disciplinary
training in
bioinformatics
Summary of INBRE Scientific Themes
Scientific
Themes
Microbiology and
Infectious Disease
Cell &
Developmental
Biology
Cancer
Neuroscience
Biotechnology
Environmental
Health & Toxicology
(EHT)
Genetics &
Genomics (GG)
Cardiovascular
Disease (CVS)
Women &
Reproductive Health
(WRH)
Bioinformatics (BI)
Others (O)
Diabetes/Obesity/Met
abolism (DOM)
Respiratory (Re)
Mental Health &
Biobehavioral
research (MH)
Bones/Joints (BJ)
Immunology (Im)
Hematology (H)
Total
63
46
42
33
23
23
15
11
10
9
9
8
5
5
4
3
2
INBRE Progress
In fiscal year 2011:
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24 INBRE Networks supported 658 research subprojects
and 1808 investigators
INBRE Networks published 610 research articles with
259 in press
INBRE investigators made 2561 scientific presentations
69 INBRE flagship institutions supported 800+ students
in summer research experiences
INBREs supported research and training at 270
undergraduate institutions including:
• 21 HBCUs
• 17 Tribal Colleges and Universities
• 21 Hispanic-serving institutions
IDeA Community-Based Research
IDeA Community Based Research
(IDeA CBR)
Goals:
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To support development of sustainable, culturally
appropriate prevention/intervention research programs
to decrease the disproportionate burden of disease
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To develop effective and stimulating environments to
facilitate training and development of clinical
investigators in areas of health disparities and special
populations
IDeA CBR
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To augment and strengthen translational /
clinical community based research programs to
address health disparities in rural and urban
special populations
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To promote interdisciplinary, multi-site
collaborations between academic researchers
across programs, community health care
providers, and community partners
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To leverage investments in CBPR made by NIH
and other agency partners
Yup’ik Perceptions of Body Weight and Diabetes:
Cultural Pathways to Prevention
Yup’ik Experiences of Stress and Coping:
Intervention Via Cultural Understanding
Contaminants and Nutrients in Alaskan Subsistence
Foods: Striking a Balance
Developing a Novel Set of Diet Pattern Biomarkers
Based on Stable Isotope Ratios
http://canhr.uaf.edu/
Environmental Health Science in Montana
Analyzing river water and fish
on the Crow Reservation to
identify environmental
contaminants
- mercury
- pesticides
- enteric pathogens
IDeA Co-funding
IDeA Co-funding
• IDeA co-funds awards to support R01 grant applications to
NIH Institutes and Centers from investigators within IDeA
eligible states.
• IDeA provides support to applicants whose proposals
received excellent ratings through the peer review process
but fell short of the Institute’s or Center’s (ICs) pay line.
• IDeA provides 70% or up to $260,000 for each of the first
two years of a selected co-funded R01 award.
• This activity was highlighted in the NIH fiscal year 2012
appropriation language.
IDeA Co-funding
• Meritorious applications were solicited from the 27 NIH
Institutes and Centers in fiscal year 2012.
• IDeA received 44 R01 applications nominated from 18 NIH
Institutes and Centers.
• The total request for IDeA co-funding amounted to $11.1
million.
IDeA Net
IDeANet
Provides:
Advanced cyberinfrastructure for biomedical and behavioral
research
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Regional approaches to relieve strategic bottlenecks in
connectivity through participating states
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Access to national high-speed computer networks for dataintensive science applications
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Computer hardware and software
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Staff in bioinformatics cores and data centers
http://www.loni.org/
Northeast Cyberinfrastructure Consortium
(NECC)
Multiple partnerships are formed between
state university systems and private
telecommunications companies to build
regional high-speed networks in VT, NH,
ME, RI and DE.
Cyberinfrastructure-Enabled
Research and Training
 A collaborative project for sequencing the
skate genome was developed between U. of
Delaware and Mount Desert Island Biological
Laboratory (MDIBL) .
 Three training workshops of Skate Genome
Annotation were performed through the
network. The data are stored on server at the
NECC shared data center at the U. of Delaware
and U. of Maine, and available for
investigators within the five NECC states.
 Research training courses were provided to
the first year medical students at MDIBL,
Dartmouth Medical School and U. of Vermont
College of Medicine.
Skate genome sequence
assembly and annotation
project
Cyberinfrastructure-Enabled Science
Education (Media Release)
MDIBL participated Howard Hughes
medical Institute’s Science
Education Alliance
Maine INBRE Newsletter
The Bar Harbor Times
National Association of IDeA Principal
Investigators (NAIPI)
National Association of IDeA Principal Investigators (NAIPI)
Provides leadership and communication for the development,
promotion and improvement of the IDeA Program
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Fosters interactions between the IDeA Program and its
constituencies
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Promotes resource sharing among IDeA programs
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Enhances the visibility of the IDeA Program
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Develops a consensus on priorities and new directions for IDeA
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Identifies and disseminates best practices within the IDeA Program
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Identifies opportunities and develops strategies to achieve the
common goals of the IDeA Program
National Association of IDeA Principal Investigators (NAIPI)
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Membership composed of Principal Investigators of INBRE and
COBRE grants
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National Committee consists of 20 members, five for each of four
Regional Divisions of IDeA (2 INBRE and 3 COBRE Principal
Investigators)
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National Committee members elected by voting members in each
division
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Executive Committee consists of 4 members elected by the National
Committee (President, Vice President, Past President and
Secretary/Treasurer)
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Working groups on an ad hoc basis
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Web-site at http://www.naipi.org
Selected Science Advances
Understanding the Role of Estrogen in Protecting
Against HIV Dementia
COBRE PI: Tom Curry, University of Kentucky College of Medicine
Background: HIV-associated dementia (HAD) occurs in about 30% of all HIV-infected
individuals despite aggressive anti-retroviral therapy. In vitro studies indicate that the
hormone estrogen (17β-estradiol or E2) acts as a neuroprotective agent by
suppressing the production of HIV-encoded proteins by astrocytes. The role of
estrogen receptors in this process is unclear.
Advance: In vitro studies revealed that astrocytes have low levels of ERα expression.
Surprisingly, the presence of ERα appeared to negate the reduction in HIV protein
production that results from treatment with estrogen. Analysis of postmortem brain
samples showed increased density of ERα-positive astrocytes in HIV-infected
individuals with dementia compared to those without cognitive deficits. The data
suggest that E2 may have the most dramatic effect in reducing HIV transcription and
acting as a neuroprotective agent early in the disease process when the
subpopulation of astrocytes expressing ERα is low.
How NCRR Grant Enabled Advance: NCRR COBRE grant (P20 RR18727), provided
support to the research project and core facilities.
Public Health Impact: Neurological complications are observed in about 60% of all
HIV infected patients, dementia in about 30% despite anti-retroviral therapy. It is
imperative that effective neuroprotective agents be developed if neurological
complications of HIV are to be prevented.
Publication Citation and Link: http://www.ncbi.nlm.nih.gov/pubmed/19886840
Mechanisms of Plasticity and Repair after
Spinal Cord Injury
PI: Scott Whittemore Univ of Louisville School of Medicine
Background: Multiple molecular, biochemical, and cellular events ensue following
traumatic spinal cord injury (SCI). The prevention and/or attenuation of significant
morbidity following SCI will require various neuroprotective strategies.
Advance: Following experimental SCI, studies in rats indicate that transplantation of
adult oligodendrocyte precursor cells (OPCs) that express ciliary neurotrophic factor
(CNTF) resulted in histological, physiological, and functional evidence of recovery.
Another study demonstrate that administration of rolipram, an investigational antiinflammatory agent, spared the death of oligodendrocytes, improved
neurotransmission, and reduced hind limb errors during grid walking. In yet another
study, the administration of agents that promote angiogenesis and endothelial cell
survival had similar neuroprotective outcomes.
How NCRR Grant Enabled Advance: NCRR COBRE grant (P20 RR15576), provided
support to the research project and core facilities.
Public Health Impact: Spinal cord injury (SCI) significantly impacts quality of life and
poses a considerable economic burden on those afflicted. Restorative therapies need
to be developed to reduce these burdens.
Publication Citation and Link: http://www.ncbi.nlm.nih.gov/pubmed/20181596
http://www.ncbi.nlm.nih.gov/pubmed/20375135,
http://www.ncbi.nlm.nih.gov/pubmed/19635528
Community-Based Participatory Research
in Indian Country
PI: Margaret Eggers, M.S., Little Big Horn College, Crow
Agency, Montana; Montana State University, Bozeman
Background: The poor well water quality and deteriorating river water quality are
impacting community health. The occurrence of disease seems greater on the tribal
reservation than in other communities. A collaborative research between Crow
Reservation community and academic partners was initiated to assess the risk of
exposure to contaminants via domestic and cultural water sources.
Advance: Little is known about how communities and academic partners can
effectively work together to conduct “community-based risk assessment,” and rarely
have Native American community members written about their perception of the
value of the CBPR process to their community, why they would participate in such
research, and how research should be conducted in their home community. The
Crow Tribal and academic research partners describe their experiences and what
they have learned in working together on a creative, collaborative CBPR project and
process.
How NCRR Grant Enabled Advance: The Montana INBRE provided initial research
funding for the first five years of the project, and continues to support the well water
testing costs.
Public Health Impact: This project provides an example of how community members
can initiate a risk assessment research in collaboration with academic partners. The
partnership improves the quality of the risk assessment and the effectiveness of
dissemination to community members.
Publication Citation:. Community-based participatory research in Indian country:
improving health through water quality research and awareness. Fam Community
Health. 2010 Jul-Sep;33(3):166-74.
Institutional Development Award Program
Opportunities for Inclusion