Transcript Miliary tuberculosis

Inflammation p.2
SYLLABUS:
RBP(Robbins Basic Pathology) Chapter:
Acute and Chronic Inflammation
PBD (Pathologic Basis of Disease)
Infectious Diseases
Inflammation p.2
109 Miliary tuberculosis
111 Tuberculous cavity of the lung
120 Actinomycosis
151 Sarcoidosis
241 Enterobiasis (appendix)
123 Trichinosis (muscle)
122 Cysticercosis (CNS)
Miliary tuberculosis (lung)
„millet seed”- size (up to 2mm) TB
granulomas:
- giant Langhans cells
- epithelioid cells
- lymphocytes
- caseous necrosis
Miliary tuberculosis
Miliary tuberculosis
Miliary tuberculosis
Tuberculous cavity of the lung
the wall of a cavity:
internal layer:
- caseous necrosis
middle layer:
- components of TB granulomas
outer layer:
-granulation tissue
-fibrous tissue
Tuberculous cavity of the lung
please note:
the micro-slide contains a fragment of a wall
of a big TB cavity,
don’t search for small cavities inside that
specimen
Tuberculous cavity of the lung
Tuberculous cavity of the lung
Actinomycosis
Actinomyces colonies surrounded by the
purulent inflammtory infiltration
Actinomycosis
Actinomycosis
Sarcoidosis
noncaseating granulomas
composed of:
- epithelioid cells,
- Langhans cells
- lymphocytes
Sarcoidosis
Sarcoidosis
Enterobiasis (appendix)
Tissue:
- normal mucosa
- or eosinophilic reaction
- or acute appendicitis
Worms:
- distinctive lateral alae („thorns” in cross section)
- sections may show eggs within worms (eggs may
also be seen alone)
Enterobiasis (appendix)
Enterobiasis (appendix)
Trichinosis (muscle)
Worms:
- encysted coiled roundworms
Tissue:
-muscle cells with inflammation including eosinophils and
macrophages
- fiber necrosis
- larval death triggers eosinophilic granulomatous
inflammation leading to calcification
or
- a chronic, inactive stage where encysted organisms are
found in the absence of any cellular response.
Trichinosis (muscle)
Trichinosis (muscle)
Cysticercosis (CNS)
Worm:
- fluid-filled cyst with eosinophilic laminated wall
lined by monolayer of rare nuclei
- older lesions fibrotic and calcified
Tissue:
- little inflammation unless ruptured
Cysticercosis (CNS)
Cysticercosis (CNS)