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Research at Karolinska Institutet
2010
Karolinska Institutet
A leading medical university
Dedicated to improving
people’s health through
research and higher
education
The largest centre for medical education and
research in Sweden
Research
– from molecule to patient
 22 departments
 600 research groups
 1,500 researchers/teachers
including 328 professors
 2,000 doctoral students
Traditions and innovations
A few examples of our notable research
achievements:
 SR – sedimentation rate
 Purification of insulin and heparin
 Sulphasalazin
 Antibodies from plasma cells
 Seldinger catheter
 Pacemaker
 Gamma knife
 Growth hormones
Nanna Svartz, the first female
professor at Karolinska Institutet
1937-1957, developed one of
the first anti-inflammatory drugs
for rheumatoid arthritis
Swedish Nobel Prize Laureates in Physiology or
Medicine – 5 of 8 are from Karolinska Institutet:
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1955 Hugo Theorell,
- the oxidation enzymes
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1970 Ulf von Euler,
- noradrenaline
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1967 Ragnar Granit,
- the visual processes
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1982 Sune Bergström &
Bengt Samuelsson,
- prostaglandins
Scientific publications 2009
 About 3,000 original articles
and 1,000 other publications
were written by researchers at
Karolinska Institutet 2009
 60 per cent have co-authors
outside Sweden
 Cited approx 50 per cent more
often than the global average
(2008)
Research funding accounts for 83 per
cent of Karolinska Institutet’s total income
Undergraduate education
Research and doctoral
education
Research revenue 2009
total SEK: 4,057 million (2008: 3,586 million)
Swedish foundations
and organisations
16%
Non-Swedish
foundations and
organisations 3%
Appropriations
33%
EU 6%
Swedish business
sector 5%
Non-Swedish
business sector
2%
Fin. revenue 0%
KI-funds 1%
County and
municipal councils
14%
Research councils
12%
Other government
funding 8%
9
Research funding
Februari 2010
10
Revenue from EU and USA
Februari 2010
11
Organisation
 Board of Research
 Strategy
 Research funding and recruitment
 Research networks
 Centres of excellence
 Core facilities
 Junior faculty
 Biosafety and ethics
 Veterinary unit
 22 Departments
 Research
 Doctoral education
The Stockholms Academic Healthcare System
Fields of research
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Cancer
Circulation and respiration
Endocrinology and metabolism
Infection
Inflammation and immunology
Neuroscience
Public and international health
Reproduction, growth and development
Tissue and motion
Nationally funded Centres of Excellence (Linné)
 Centre of Excellence in Developmental Biology
for Regenerative Medicine
 STARGET – a cancer research network
 Center for Research on Inflammation and Cadiovascular
Disease, CERIC
 The Human Regenerative Map
 Linné Centre for Prevention of Breast and Prostate
Cancer
Other nationally funded Centres of Excellence
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Aging Research Centre
Centre for Allergy Research
Centre for Health Equity Studies
Centre for Infectious Medicine
Stockholm Brain Institute
Strategic Research Centre for Studies of Integrative
Recognition in the Immune System
 Structural Genomics Consortium
 Swedish Brain Power
Core facilities in
many areas
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KI Biobank
Registers
Bioinformatics and biostatistics
Clinical trial centres
Experimental models
Expression analysis
Genomics
Proteomics
Visualisation techniques
Strong Research Potential
Basic Research and Clinical Research Come Together
Translational Research
Research profile
Epidemiology
 KI Biobank - core facility for all research
 contains samples of tissue, blood, serum,
plasma, DNA and other biological specimens
 Twin Registry – the largest in the world
 invaluable resource when correlating
between genes, lifestyle and environment
 Medical informatics
 strong competences in health informatics and biostatistics
Research profile
Cellterapy – from stem cell to therapy
Advanced stem cell research
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Strong clinical expertise in cell therapy and transplantation medicine
International leadership in developmental biology
Embryonic stem cell lines
Research focus on
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Parkinson’s disease
Spinal cord injuries
Diabetes
Musculature disease
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Tissue impairment after cardiac infarction
Research profile
Neuroscience
 Approx. 20 per cent of all research at Karolinska
Institutet is in neuroscience
Three world-leading research centres
 Spinal Cord Research Centre
 Gather about 10 research groups
 Stockholm Brain Institute
 Interdisciplinary research in neuroscience,
psychology and computer science
 Alzheimer Centre
 Translational research in brain aging,
dementia and Alzheimer's disease
Research profile
Infectious diseases and immunology
 Leading researchers in virology, bacteriology,
parasitology and immunology
 Neighbouring the largest infection clinic in Sweden
 Advanced laboratory facilities
 Strong international collaborations
Research focus
 Global infections – HIV, malaria, tuberculosis,
pneumonia
 Basic immunology, inflammation and infection
medicine
Research profile
Cancer
 Basic research in the emergence/origin
and development of cancer
 Cancer epidemiology
 Therapy research, e.g. hormone,
immune, and gene therapy
 Optimizing of radio therapy
 Clinical trials
 Quality of life
Research profile
Inflammatory diseases and allergy
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Reumatoid arthritis
Multipel sclerosis
Nerve and muscle inflammation
Immune defects
Autoimmunity
Allergies and eczema
Asthma and COPD
Atherosclerosis
Research profile
Metabolic diseases
 Obesity
 Advanced research in adult and child obesity
 Close clinical collaboration
 Diabetes
 Basic research in diabetes
research
 Treatment research
 Stem cell research
 Cardiovascular research
 Inflammatory factors
 Cholesterol metabolism
 Gender aspects in diagnosis and care
Research profile
Aging research
 Aging Research Centre
 Research from a medical, psychological and
socioeconomic perspective
 Dementia
 Early diagnosis and treatment of cognitive impairment
 Alzheimer Centre
 Swedish Brain Power
 A national research consortium in
neurodegenerative diseases
Research profile
Global health
Partnerships on all continents
Research focus on poverty
and health
Vaccines – HIV, malaria, tuberculosis
 Reproductive medicine
 Occupational medicine
 Psychiatry
 Geriatrics
 Humanitarian disaster assistance
Research collaborations
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Health care sector
Swedish and foreign universities
Industrial partners
International agreements with
organizations in Europe,
North America, Africa and Asia
 Offices in China and Singapore
Karolinska Institutet Innovation
- from brains to business
 Promotes the results of biomedical
research to be developed into new
products and applications
 Provides the means for researchers
to develop their research results
commercially
 Offer project management, funding
for patent protection, legal advice
and business development
 Allows researchers access to an extensive network of contacts
within the international pharmaceutical industry
Karolinska Institutet Innovation
 Reviewed more that 1 100
academic inventions
 More than 40 companies
formed since 1996
 35 license agreements concluded
 The system’s portfolio
companies own about
100 patents
 30 development project
are in its portfolio pipeline
More information: ki.se
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