Transcript In Singapore….. - GlobalSuccess4Life.com

Cardiovascular Health
HEALTHY
CARDIOVASCULAR
HEALTHY
HEART
HEALTHY
ARTERIES
HEALTHY
BLOOD
PRESSURE
SYSTEM
Globally….
• 17 million people die of
cardiovascular disease each year.
• In the United States, coronary heart
disease is the single biggest killer and
is responsible for 1 in every 5 deaths.
• In Europe, cardiovascular disease
causes 4 million deaths each year.
• In Asia, the figure is on the rise.
In Singapore…..
• Heart disease is the No.2 killer after
cancer.
• Approximately 2,000 people get heart
attacks every year. Of these 50% die
because they do not receive medical
help fast enough.
• Death rate due to cardiovascular
disease was 7.7% ( 1957 ) to 26.3 %
( 2001 ).
In Singapore…..
• Death due to ischaemic disease is
100/100,000 population.
• United States is 125/ 100,000,
Australia 97/100,000, Japan
22/100,000 and Hong Kong
40/100,000.
According to the ‘State of Health
2001’ report….
• 27% of Singaporeans are
hypertensive.
• 58% are physically inactive during
their leisure time.
• 24% are overweight with 6 % being
obese.
Surveys show that most
women are far more
afraid of breast cancer
than of cardiovascular
disease (even though 1
in 30 women’s deaths is
from breast cancer while
1 in 2.4 is from CVD
2002 Heart and Stoke Statistical
Update, American Heart Association
The Pathobiological Determinants
of Atherosclerosis in Youth (PDAY)
Study Group: ~ 3000 persons
dying of external causes
• Atherosclerosis begins in
childhood
• By age 15, all subjects had
atherosclerosis
McGill HC Jr, McMahan CA, Herderick EE, Zieske AW, Malcom GT, Tracy RE,
Strong JP; Circulation 2002 Jun 11;105(23):2712-8. Comment in: Circulation.
2002 Jun 11;105(23):2696-8.
Zieske AW, Malcom GT, Strong JP. Natural history and risk factors of
atherosclerosis in children and youth: the PDAY study. Pediatr Pathol Mol
Med 2002 Mar-Apr;21(2):213-37
Strong JP, Zieske AW, Malcom GT. Lipoproteins and atherosclerosis in children:
an early marriage? Nutr Metab Cardiovasc Dis 2001 Oct;11 Suppl 5:16-22
Estimated Direct and Indirect Costs
of Cardiovascular Diseases and Stroke
United States: 2002
Billions of
Dollars
329.2
350
300
250 214
200
111.8
150
100
49.4 47.2
23.2
50
0
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Statistical Update,
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American Heart
Association
As recently as five
years ago, most
physicians would have
confidently described
atherosclerosis as a
straight plumbing
problem.
Scientific American May, 2002 pg. 48
Atherosclerosis:
The NEW VIEW
• The long held conception of how the
disease develops turns out to be
wrong.
• Not a straight plumbing problem!
• Inflammation fuels the development
and progression of Atherosclerosis
Peter Libby Scientific American May 2002, p 47-55.
Habitual response to
events as if they were
life-threatening generates
a repetitive
stress/inflammatory
response that
may result in
atherosclerosis
Black PH, Garbutt LD. Stress, inflamation and
cardiovascular disease. J Psychosomatic Res
2002, 52, 1-23.
How many people……
1) Hypertension ?
2) High cholesterol ?
3) Diabetes ?
CVD: How
does it happen?
• Infections can inflame
arteries and lead to heart
attacks
• Six microbes associated
with CVD risk
–Cytomegalovirus
–Hepatitis A
–Herpes Simplex viruses 1 and 2
–Chlamydia pneumoniae
•
American College of Cardiology
–H. Pylori
March 2000
Targeted Transfer Factor
• Managed environment
• Unfertilized eggs
Egg Allergies
• Prevalence of probable food allergy
– 0.61% for peanut.
– 0.53% shrimp
– <0.27% for wheat
– 0.09% for cow's milk and egg
• Main egg allergens are found in
whites
•
•
Woods RK, Thien F, Raven J, Walters EH, Abramson M. Prevalence of food
allergies in young adults and their relationship to asthma, nasal allergies, and
eczema. Ann Allergy Asthma Immunol 2002 Feb;88(2):183-9
Anet J, Back JF, Baker RS, Barnett D, Burley RW, Howden ME. Allergens in
the white and yolk of hen's egg. A study of IgE binding by egg proteins. Int
Arch Allergy Appl Immunol 1985;77(3):364-71
Magnesium
“Magnesium deficiency has
been shown to correlate
with a number of chronic
cardiovascular diseases,
including hypertension,
diabetes mellitus, and
hyperlipidemia.”
Fox C, Ramsoomair D, and Carter C. South Med J
2001; 94(12) :1195-20. Abstract.
Magnesium
“The American diet is
low in magnesium,
and with modern
water systems, very
little is ingested in the
drinking water.”
Innerarity S. Crit Care Nurs 2000; 23(2): 1-19. Abstract.
Magnesium
• Allows blood vessels to relax
not spasm
• Required for metabolic
efficiency
• Deficiency leads to hypertrophy
or enlargement of the heart
• Magnesium is a NATURAL
calcium channel blocker
(1)
(1)
(2)
Stigson, L. and I. Kjellmer (1997). "Serum levels of MAGNESIUM at birth
related to complications of immaturity." Acta Paediatr 86(9): 991-4.
Med Text refs
Dietary Copper Deficiency
–high blood pressure
–enhancement of
inflammation
–anemia
–reduced blood clotting
–arteriosclerosis
Saari JT and Schuschke DA. Biofactors 1999; 10(4): 359-75.
Zinc
Zinc requirements
of the vascular
endothelium
are increased
during inflammatory conditions
such as atherosclerosis.
Hennig B, Meerarani P, et al. Br J Nutr 1999; 81(2): 85-6.
Zinc
Both men and women
who took zinc
supplements had
higher HDL
cholesterol levels than
non supplementing
individuals.
Neggers YH, Bindon JR, et al. Biol trace Elem Res 2001; 79(1): 1-13.
Selenium
• Selenium deficiency leads
to an increased frequency
of cardiovascular
diseases.
• “Selenium is well
recognized as a
preventive factor for
cancer and cardiovascular
diseases.”
Racek J, Holecek V, et al. Vnitr Lek 1999; 45(6): 373-8.
Miyazaki Y, Koyama H, et al. Nippon Koshu Eisei Zasshi 2001; 48(4): 243-57.
Hyperhomocysteinemia
• Elevated levels of
homocysteine
promote the
development of
atherosclerosis.
• Approximately 10% of coronary artery disease
cases are attributable to hyperhomocysteinemia.”
• Folic Acid  -25% homocysteine
• Vit B12  -7% homocysteine
Zacarias-Castillo R, Hernandez-Rebollar AE, et al. Gac Med Mex 2001; 137(4): 335-45.
Ubbink JB, Becker PJ, Vermaak WJ. Nutr Rev 1996; 54(7): 213-6. Clarke R, Armitage J. Semin Thromb
Hemost 2000; 26(3):341-8. Auer J, Berent R, et al. Wien Med Wochenschr 2001;151(1-2):25-8.
Vitamin C
• Antioxidants, such as vitamin C,
may slow atherogenesis.
• An increased intake of vitamin
C is associated with a reduced
risk of chronic diseases such as
cancer, cardiovascular disease,
and cataracts
Price KD, Price CS, et al. Atherosclerosis 2001; 158(1):1-12.
Carr AC and Frei B. Am J Clin Nutr 1999; 69(6): 1086-107.
Vitamin E Supplement Benefits
• Decreased cardiac events:
– U.S. Nurses’ Health Study
- 34% risk reduction
– U.S. Health Professionals’ Study
- 39% risk reduction
– Iowa Women’s Health Study
- 47% mortality reduction
– Cambridge Heart Antioxidant Study
- 47% infarct reduction
Emmert DH, Kirchner JT. Arch Fam Med
1999; 8(6): 537-42. Abstract.
Lysine and Herpes
• “Herpes group viruses, especially
cytomegalovirus and herpes simplex
virus type 1, have been associated with
both atherosclerosis and restenosis.” (1)
• L-Lysine monohydrochloride is used as
a suppressant of recurrent herpes
simplex infections. (2)
(1) Leinonen M, Saikku P. Scand Cardiovasc J 2000; 34(1): 12-20.
(2) Flodin, NW. J Am Coll Nutr 1997; 16(1): 7-21.
Arginine & NO
• Nitric oxide is a relaxing factor
• L-Arginine is the precursor for
nitric oxide (NO).
• Oral L-Arginine
supplementation can improve
symptoms of cardiovascular
disease.
(Note: Magnesium is also critical.)
Wu G, Meininger CJ. J Nutr 2000; 130(11): 2626-9.
Boger RH, Bode-Boger SM. Annu Rev Pharmacol Toxicol 2001;41:79-99.
Resveratrol
•
•
•
•
Antioxidant,
Promote nitric oxide production,
Inhibit platelet aggregation,
Increase high-density lipoprotein
(HDL) cholesterol,
• Cardioprotective agent.
Bhat KPL, Kosmeder JW, 2nd. Antioxid Redox Signal 2001; 2(6): 1041-64.
Coenzyme Q10
• Useful in congestive heart failure,
angina pectoris, cardiomyopathy,
coronary artery disease and in the
preservation of myocardium.
• Coenzyme Q10 is normally found
in LDL cholesterol and it inhibits
its oxidation.
• Cardiac levels of Coenzyme Q10
were decreased in heart disease.
Singh RB, Niaz MA, et al. J Assoc Physicians India 1998; 46(3): 299-306.
Kucharska J, Gvozdjakova A, et al. Bratisl Lek Listy 1996; 97(6): 351-4.
Red Yeast Rice
• Reduces
– total cholesterol,
– LDL cholesterol, and
– total triacylglycerol concentrations
• “Provides a new, novel, food-based
approach to lowering cholesterol in
the general population.”
Heber D, Yip I, et al. Am J Clin Nutr 1999; 69(2): 231-6.
Cardio Herbs
• Hawthorne
–Salt Balance, Vessel Integrity
• Ginkgo Biloba
–Antioxidant, stabilizer
• Garlic
–Antimicrobial, Antioxidant
SUMMARY of the Problem
• CVD is the #1 Killer
• CVD Starts Early
• CVD is NOT a Simple Plumbing
Problem
• The Immune System is Critically
Involved in CVD
• Infection may Initiate CVD
• Metabolic Toxins and Chronic
Stress Can Trigger Chronic
Inflammation
Summary of a Solution
•
•
•
•
Control Infection
Control Inflammation
Help the Blood Vessels Relax
Protect the Heart and Arteries
from Toxin and Oxidative Damage
• Increase the Pumping Efficiency
of the Heart
Summary of Supplements
• Tune the Immune System
– Targeted TF, Zn, Lysine
• Help relax the Blood Vessels
– Arginine, Mg, Ginko, Hawthorne,
Butcher’s Broom
• Help support the Pumping
Efficiency of the Heart
– Mg, CoQ10
Summary of Supplements
• Help block Oxidative Damage
– Se, Cu/Zn;
– Beta carotene, Vit C, Vit E,
Resveratrol,
• Help improve Toxin Clearance
– Folic Acid, Vit B6 and Vit B12
• Help maintain Cholesterol
Balance
– Red Rice Yeast, Garlic