Anatomy_and_Physiology_files/Blood and cardio
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Transcript Anatomy_and_Physiology_files/Blood and cardio
How does a vampire get clean? …
…He takes a blood bath!!!
Blood
and The Cardiovascular System
Volume and Composition
Average human adult has a blood volume
of about 5.3 liters.
Varies with size and sex of individual
Sample of blood =
45% cells by volume – called Hematocrit (HCT) or
Packed Cell Volume (PCV)
Types of CellsRed Blood Cells
White Blood Cells
Platelets
Volume and Composition
Other 55% is a clear, straw colored liquid
called plasma.
Plasma components:
Water
Proteins
Amino Acids
Nutrients
Electrolytes
Wastes
Blood
Where does the color come from?
Hemoglobin
True or false? Oxygenated blood is red,
unoxygenated blood is blue.
FALSE!
Oxygenated blood = bright red
Unoxygenated = deep dark red (maroonish)
DQ - Why do blood vessels look blue?
Red Blood Cells
Also called Erythrocytes
Primary function – transport gases to and from
cells
No Nucleus – Why?
Biconcave Shape –Thin in the middle and thick
on the outside.
Why might these be shaped in this way?
Reason #1 – Increases surface area, assisting in
transportation of gases
Reason #2 - places the membrane closer to
oxygen-carrying hemoglobin in the cell.
Reason #3 – Shape allows it to squeeze through
the tiny capillaries.
Erythrocytes
What is hemoglobin?
An iron based protein in red blood cells
that transports oxygen and carbon
dioxide.
A single RBC can contain over 250
million molecules
Each molecule can bind 4 oxygen
molecules
White Blood Cells
Also known as Leukocytes
Primary Function = fight disease and
infection
Why would your WBC count increase when
you are sick?
Leukocytosis - elevated WBC count
Leukopenia - abnormally low WBC count
Leukocytes
5 Types (names, amount in mm3, function)
Neutrophils (3000-7000) - phagocytize small
particles
Eosinophils (100-400) - kill parasites, controls
inflammation
Basophils (20-50) - release heparin and
histamine
Lymphocytes (1500-3000) - provides immunity,
fights tumors
Monocytes (100-700) - phagocytize large
particles
Platelets
Also called Thrombocytes
Not necessarily Red Blood Cell fragments
Arise from Megakaryocytes
These fragment, releasing small sections into
cytoplasm
Each platelet:
~ half the size of a RBC
Lack a nucleus
Function in the formation of blood clots
Plasma
92% Water
Functions
1. Transport materials (such as?)
2. Regulate Fluid and electrolyte levels
3. Regulate pH
Components
Plasma proteins
Nutrients and Gases
Plasma Electrolytes
Plasma Proteins
3 Types
Albumins
Smallest in Size, make up 60% of volume
Function – Osmotic Pressure
Why are so many needed?
Globulins
Alpha and Beta – transport lipids and vitamins
Gamma – are a type of antibody
Fibrinogen
Least common plasma protein (4%)
Function – Blood Coagulation
Nutrients and Gases
Includes amino acids, simple sugars, and lipids
Where do these nutrients come from?
How are lipids (not water soluble) able to be in the
plasma?
Lipoproteins
Low density Lipoproteins
High Density Lipoproteins
Which one is good, which is bad?
How do they have different densities?
Plasma Electrolytes
Plasma Electrolytes
Include: Sodium, Potassium, Calcium, Chloride,
and others
Where do they come from?
Large intestine
Electrolyte Purposes:
1. Maintain Osmotic Pressure
2. Supply tissues with electrolytes when
needed
3. Regulate pH
Blood Drop Activity
• As a class, we will be a blood drop, you
will be assigned a specific part of the
blood drop.
• It will be your job to describe your part
without mentioning what you are.
• We will have a class riddle session to
guess the part of blood that each person
is.
Production of a Blood Cell
• Occurs in the red bone marrow
• Can be triggered by different things
– Megakaryocytes – tissue damage
– Leukocytes – foreign invaders
– Erythrocytes – oxygen levels and erythropoietin
• Low oxygen = more erythropoietin (more production)
• High oxygen = less erythropoietin (less production)
• All types start out as a Hemocytoblast (blood stem cell)
• Then differentiates into:
– Lymphoid cells, which become lymphocytes
– Myeloid cell, which will become a leukocyte, erythrocyte or
thrombocyte
Blood Clotting
• Hemostasis – stoppage of bleeding
• Done in three ways
• 1. Platelet plug
– What is this?
• Platelets typically repelled by walls of blood
vessel
• But when wall is broken, collagen is exposed and
the platelets are attracted to and stick to that.
• Platelets then release chemicals to attract more
platelets
– This keeps building, creates a dam.
Hemostasis
• Platelets also release serotonin, this
causes:
• 2. Vasoconstriction
– What is this?
• Muscular layers in the walls of the vessel
contract
– Can sometimes close the vessel completely
– May only last for a few minutes
Hemostasis
• The damaged tissue will release a chemical that
starts the process of:
• 3. Blood Coagulation
– What is this?
• Formation of a blood clot
• This is the most effective, but takes the most
time.
• A chain of events must occur for this to happen
– Prothrombin to thrombin
– Fibrinogen to Fibrin
– Fibrin “net”
• How would anticoagulants affect this?
Hemostasis
• What must happen?
Blood Types
• On our RBCs we have antigens
– Identifiers to let our body know our cells
• Our blood also contains antibodies against
other blood types
– This will attack blood types with other
antigens (ex. Type A has anti-B antigens and
will attack type B cells)
– This will cause agglutination
• This is why blood type is so important
during blood transfusions.
Blood Types
Blood type
Antigens
Antibodies
Possible Donor
types
A
A
Anti-B
A
O
B
B
Anti-A
B
O
AB
A and B
None
AB, A, B, O
O
None
Both
O
O = Universal Donor
AB = Universal Recipient
• There are other factors (Rh factor) that play a
role too but we are not going to worry about those
Blood Types
• The genes for A and B are codominant, the
genes for type O are recessive.
• This means that there are four possible blood
types
• And 6 possible genotypes
•This is useful in eliminating potential fathers in
paternity cases
Blood Type
Possible Genotypes
A
AA
AO
B
BB
BO
AB
AB
O
OO
Parts of the heart
• External Anatomy
• Average - 14 cm long (base to apex)x 9
cm wide and 280 g
• Covered with the Pericardium
– A sac like structure filled with fluid
surrounding the heart.
• Why would this be here?
• Used mainly for protection
• Walls of the heart are thick and muscular
– Why would this be?
Parts of the heart
• Internal Anatomy
• 4 Chambers
• Atria – Blood enters heart here
– From where?
• Body or the lungs
• Ventricles – Blood leaves heart from here
– The walls are much thicker around the
ventricles, why
Parts of the heart
• Atrioventricular valves
– What are they going to do?
• Separate the atria and ventricles
• They prevent blood from flowing the wrong
direction
• Tricuspid valve – between right atrium and
right ventricle
• Mitral valve – between left atrium and left
ventricle
• Also valves at the beginning of pulmonary
veins and aorta
Parts of the Heart
• What would be a problem if the valves
would not working correctly?
– AKA Heart murmur
• Heart becomes inefficient – can cause
complications
*****Sound of the heart beat comes*****
from the valves closing.
Cardiac Cycle
• AKA Heartbeat
• Atrial walls contract while ventricular walls
relax
• Ventricular walls contract while atrial walls
relax
• What valves would close during each of
these processes?
• Atrial contraction = pulmonary and aorta
• Ventricular contraction = Mitral and tricuspid
Path of Blood
•
•
•
•
•
•
•
•
•
•
Right atrium
Right ventricle
pulmonary artery
lungs
pulmonary vein
left atrium
left ventricle
aorta
body
vena cava right atrium
Electrocardiogram (ECG/EKG)
• Records electric impulses in the heart
– Where do these come from?
• 3 parts
• P wave – atrial contraction
• QRS complex – ventricular
contraction
• T wave – ventricular relax.
Blood Vessels
•
•
•
•
•
3 types
Arteries
Veins
Capillaries
All of these provide a closed system for
blood to continuously flow through
– But each are structurally and functionally
different.
Blood Vessels
• Arteries
• Carry blood away from the heart at high
pressures
• Characteristics of the walls:
– Strong
– Thick
– Elastic
• Why would the walls have these
characteristics?
Blood Vessels
•
•
•
•
Veins
Designed to carry blood back to the heart.
Run parallel to arteries
Wall is similar in structure to arteries, but
muscular layer is less developed.
– Wall is thinner, weaker, and less elastic
Blood Vessels
• Capillaries
• Smallest of blood vessels
– Some are so small that only a single RBC can
make it through at a time
• Have extremely thin walls
• Why would they have such thin walls?
• This is the point where gases and
nutrients are exchanged.
Blood Pressure
• Measures amount of pressure on large
arteries
• Two numbers (i.e. 120/70)
• First number is systolic pressure
– Amount of pressure when heart is contracting
• Second number is diastolic pressure
– Amount of pressure when heart is relaxed
• Why is high or low blood pressure bad?