Transcript Introduction - People.vcu.edu

Development
• In time
• In space
End result...
Too complicated
End result... much simpler
Bacillus sporulation
Anabaena heterocysts
Myxobacteria fruiting
Caulobacter cell cycle
Bacillus subtilis
Temporally regulated differentiation
Restart
Pause
Start
Caulobacter crescentus
Cell cycle-regulated differentiation
Anabaena
Spatially regulated differentiation
Time after nitrogen removal
0h
3h
6h
9h
12 h
Myxococcus xanthus
Socially regulated differentiation
Feast
Famine
Route to altered states in bacteria
Bacillus, Anabaena, Myxococcus
Starvation Permissive
conditions
Initiation
pH, Fe,...
Pathogens
Signal
transduction
Altered State