Transcript Diapositiva 1 - The EndoExperience

Pulpal and periapical
immune responses
to infection
Carmen D. Cohn
There is no evidence that
necrotic pulp tissue per se
can elicit periapical
inflammation, in the absence
of bacteria.
Carmen D. Cohn
Moller & Fabricius 1981
No apical inflammation
26 bacteria-free
7 months
78 monkey teeth
with
aseptically necrotized pulps
52 bacteria infected
Apical periodontitis
Carmen D. Cohn

Periapical
responses to
pulpal infection
Carmen D. Cohn
Bacterial products
IL-1, IL-6
TNFα
PGE
MF
MHC-II
Th
IL-1
+
Ag
B
IL-2
Periapical inflammation and bone destruction
Carmen D. Cohn
Periradicular lesions - barrier
Microbial
Epithelial
plugs
Complement
Antibodies
Microorganisms
products
PMNs
Granulomatous
tissue
Defence
elements
Very few endodontopathogens can advance through the barrier.
Carmen D. Cohn
Extraradicular microorganisms




Abscessed AP
Actinomyces spp, Propionibacterium
propionicum
Infected radicular cysts
Infected material displaced into the periapical
tissues
Possible factor in the failure of the endodontic therapy.
Carmen D. Cohn