Transcript Chapter 17

CH 17 – WBC Morphology
Five Types of Leukocytes (WBCs)
Granular Leukocytes
Eosinophil
Neutrophil
Basophil
Neutrophil
 60-70% of all WBC’s
 Anatomy
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10-12 µm diameter
2-6 nuclear lobes
Fine, pale inconspicuous
granules
 Physiology
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

Respond first to bacteria
damage by chemotaxis
Phagocytosis
After engulfing pathogen
releases several chemicals



lysozyme
strong oxidants
defensins
Eosinophil
 2-4% of all WBC’s
 Anatomy
 10-12 µm diameter
 2 connected nuclear
lobes
 red/orange large,
uniform granules, do
not obscure the nucleus
 Physiology
 exit capillaries, enter
tissue fluid
 combat parasites
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
histamine
phagocytize antigenantibody complexes
Basophil
 0.5-1% of all WBC’s
 Anatomy
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
8-10 µm diameter
bilobed or irregular nucleus
round, blue-black granules
may obscure the nucleus
 Physiology
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exit capillaries to enter
tissue fluid
mature into mast cells


release heparin,
histamine, serotonin –
stimulate inflammation
Hypersensitivity
(allergic) reactions
Agranular Leukocytes
Lymphocyte
Monocyte
Lymphocytes
 20-25% of all WBC’s
 Anatomy
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

7-15µm
nucleus large and
dark stained, round
or indented
cytoplasm forms a
pale blue rim
around the nucleus
Monocytes
 3-8% of all WBC’s
 Anatomy
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14-19 µm
indented or kidney-shaped
nucleus (not round)
cytoplasm foamy
 Physiology
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slower to arrive but survive
longer
enlarge, differentiate into
fixed and wandering
macrophages
remove microbes, cellular
debris, following injury
End
WBC Morphology
CH 17