Transcript Chapter 17
CH 17 – WBC Morphology
Five Types of Leukocytes (WBCs)
Granular Leukocytes
Eosinophil
Neutrophil
Basophil
Neutrophil
60-70% of all WBC’s
Anatomy
10-12 µm diameter
2-6 nuclear lobes
Fine, pale inconspicuous
granules
Physiology
Respond first to bacteria
damage by chemotaxis
Phagocytosis
After engulfing pathogen
releases several chemicals
lysozyme
strong oxidants
defensins
Eosinophil
2-4% of all WBC’s
Anatomy
10-12 µm diameter
2 connected nuclear
lobes
red/orange large,
uniform granules, do
not obscure the nucleus
Physiology
exit capillaries, enter
tissue fluid
combat parasites
histamine
phagocytize antigenantibody complexes
Basophil
0.5-1% of all WBC’s
Anatomy
8-10 µm diameter
bilobed or irregular nucleus
round, blue-black granules
may obscure the nucleus
Physiology
exit capillaries to enter
tissue fluid
mature into mast cells
release heparin,
histamine, serotonin –
stimulate inflammation
Hypersensitivity
(allergic) reactions
Agranular Leukocytes
Lymphocyte
Monocyte
Lymphocytes
20-25% of all WBC’s
Anatomy
7-15µm
nucleus large and
dark stained, round
or indented
cytoplasm forms a
pale blue rim
around the nucleus
Monocytes
3-8% of all WBC’s
Anatomy
14-19 µm
indented or kidney-shaped
nucleus (not round)
cytoplasm foamy
Physiology
slower to arrive but survive
longer
enlarge, differentiate into
fixed and wandering
macrophages
remove microbes, cellular
debris, following injury
End
WBC Morphology
CH 17