Transcript Enteric defensins are essential regulators of intestinal

Enteric defensins are essential
regulators of intestinal micorbial
ecology
Nita Salzman
Nature immunolgy 11, 76-83
The problem
Friendly
bacteria
??
?
Background
Lumen
Friendly
bacteria
Mucous
membrane
Innate
proinflamatory
response
TL5,9
Il-1, a,Bbefensins
Lamina
Cytokines
IgA
DC
Propria
Tcell
IL-17
Previously
DEFA-5
Protection against
Salmonella
Hypothesis
• Addition of DEFA5, kills Salmonella
directly, therefore providing protection, or,
• DEFA5 alters intestinal flora which in turn
provides protection against the pathogen.
Expression
Bacterial colonisation mRNA
So ..?
• So far,
• mice expressing functional DEFA5, have a
different microbiological ecology. Which is
not due to other paneth cell functions.
Recipricating data
SFB
Total numbers
Th-17 cells
The problem refined
Friendly
bacteria
IL-17 T
cells
Implications
•
•
•
•
Crohns type diseases
Probiotics
Allergies
Antibiotic treatments!