Transcript A Short Introduction To Platelet Rich Plasma Therapy

A Short Introduction To
Platelet Rich Plasma Therapy
Blood Components
• Blood Components
-93 % RBCs
-6 % Platelets
-1 % WBCs
-Plasma(Liquid Component)
• PRP
- 94 % Platelets and Plasma
- 5 % WBCs
Function of Blood Cells
Leukocytes ;
Infection Removal Bacteria
Erythrocytes;
Oxygen Transport
Platelets;
Blood clotting and wound healing.
Platelets
• Platelets derived from megokaryocytes
• Important in Hemostasis/Clotting
• Platelets are normally activated during the
inflammatory phase to begin healing
• Role in the normal healing response via the
secrection of local growth factors
• Growth factors released by platelets recruit
reparative cells and augment soft-tissue repair
What Is PRP
Platelet-rich plasma (PRP) is blood plasma that has
been enriched with platelets. As a concentrated
source of autologous platelets, PRP contains (and
releases through degranulation) several different
growth factors and other cytokines that stimulate
healing of bone and soft tissue.
PRP Application Areas
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Orthopedic and Traumatology
Maxillo-Facial Surgery
Plastic/Reconstructive Surgery
Cardiac Surgery
Cosmetic Surgery
General Surgery
Sports Medicine
Hair Transplantation
Skin Rejuvanation
Platelet Growth Factors
Growth Factor
Sources
Transforing Growth Factor –Beta
TGF-β
Platelets,extra cellular matrix of bone,
Cartilage matrix,activated TH cells and natural killer
cells,macrophages/monocytes
And neutrophils.
Basic Fibroblast Growth Factor,
bFGF
Platelets,macrophages,mesenchymal
cells,chondrocytes,osteoblasts
Epidermal Growth Factor
EGF
Platelets,macrophages,monocytes
Vascular Endothelial Growth Factor
VEGF
Platelets,endothelial cells
Connective Tissue Growth Factor
CTGF
Platelets through endocytosis from extraCellular environment in bone marrow.
Action of PRP Growth Factors
Healing Cascade
Platelet Count
Normal Platelet Count
Concentrated Platelet Count
Cellular Factors İn Wound Healing
Benefits of PRP in the Healing Cascade
Easy PRP Kit
Advantages
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Easy to use
High concentrated PRP
Buffy Coat
Cost Effective
Simple Operation
No Contamination by Pathogens
Convenient for Office use
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