Transcript Document

COUNTRY PAPER
on
"BIOTECHNOLOGY"
presented in the
SECOND EXPERT GROUP MEETING ON BINASIA
HELD IN BANGKOK, THAILAND
FROM JANUARY 24-25, 2006
PREPARED BY
PROF. DR. S. RIAZUDDIN
Director
Centre Of Excellence Molecular Biology
Thokar Niaz Baig, Canal Bank Road
GENES CAN BE ISOLATED
FROM BACTERIA, VIRUSES,
FUNGI, PLANTS OR ANIMALS
AND MADE TO EXPRESS IN
CHOICE HOSTS
IT WILL SOME DAY BE POSSIBLE TO
MANIPULATE GENES
FOR ALMOST ANY CHARACTER
RESULTING IN THE PRODUCTION
OF DESIRED TRAITS ON WHATEVER
SCALE WE DESIRE
PRODUCTS AND SERVICES OF
BIOTECHNOLOGY ARE EMERGING
AS A VERY SUBSTANTIAL
REVENUE-GENERATING SOURCE
FOR THE ECONOMIES OF
DEVELOPED NATIONS
BIOTECH MARKET ANALYSIS OF
DIFFERENT BIOTECH SECTORS
a) Genetically Modified (GM) Crops
b) Biopharmaceuticals
c) Molecular Diagnostic
CURRENT STATUS OF
BIOTECH RESEARCH IN
PAKISTAN
Centre of Excellence in Molecular Biology (CEMB)/
Centre for Applied Molecular Biology
University of the Punjab, Lahore
 Bt transgenic rice and Bt cotton.
 Disease free seeds of potatoes, sugarcane and gladiolus
flowers.
 Bt bioinsecticide, mycopesticide.
 Prenatal diagnosis of -thalassemia.
 DNA Typing for crime investigation and parenthood
identification,
 PCR based diagnosis of infectious diseases (hepatitis
B&C and tuberculosis) – services and kits.
 Human recombinant proteins – interferon alpha 2a and
insulin.
National Institute of Biotechnology &
Genetic Engineering (NIBGE),
Jhang Road, Faisalabad

BioPower developed to support growth of different grains, fodder
legumes, cereals, cotton etc.

DNA purity test for basmati rice (Export National focal point).

Production of industrial Enzymes.

PCR/ DNA based diagnostic tests for cotton/ banana viruses.

Inocula for methane and ethanol production.

Test for formaldehyde, heavy metal and microbiological content for
export goods in export goods.

Broad spectrum virus resistant GM cotton and GM tomato. oduction of
citric acid and Alpha-amylase.

Model process for coal desulphurisation at industrial scale.

Biotechnological process for recovery of copper from indigenous ores.

Microbial consortia for waste treatment for various industries
Centre for Molecular Genetics (CMG),
University of Karachi, Karachi

Biological filters using indigenous resources for the
treatment/detoxification of industrial effluents. This technology
could be commercialized to recycle the waste matter and recovery
of heavy metals.

Development of oil degrading bacteria.

Production of biodegradable plastic (PHA) by bacteria.

Production of alginate and water absorbing polysaccharides by
bacteria using the sugar- cane waste. These could be used for
improving fertility of agricultural lands, for preparing materials like
tissue papers and baby diapers.

Bacterial production of dextran.

Production of antimicrobial compounds from marine bacteria
(pharmaceutical industry).

Development of plant growth promoting bacteria which have the
ability to degrade complex phosphate compounds to liberate free
phosphorus and produce plant growth hormones.
ISSUES AND CONCERNS
REGARDING
COMMERCIALIZATION OF
BIOTECHNOLOGY
PRODUCTS AND
PROCESSES
IMPACT ON TRADE OF
ASIAN COUNTRIES
(a) Switching on to new raw material base may
actually be effectuated much quicker than in the
past,
(b) a large number of commodities will undergo
major changes in supply and demand at the
same time, and
(c) alternative sources for foreign exchange
earnings may be more limited than at other
historical junctures.
INHERENT CONSTRAINTS
IN THE PROMOTION OF
APPLICATIONS OF
BIOTECHNOLOGY IN
ASIAN COUNTRIES
VARIOUS SEGMENTS INVOLVED IN
MARKETING LABORATORY RESEARCH
1
Science Managers (Based on needs – Technical
feasibility vizs-à-vis infrastructure and market
trends – which other institions are working to
produce it – value addition / cost economics)
Conceiving a project
Identification of a
Product/Process
2
Laboratory
Research
Sound Scientific Plan (Molecular
Biology)
Legal Protection/ Patent
3
Upscale;
Fermentation
4
Chemical Engineers (Economy, byeproduct, other products)
Ease of Distribution (Shelf
Life; persistence, mode of
application)
Formulation
5
Field Trial
6
Packaging &
Marketing
Compliance with
approval/ Regulatory
Procedure
By the Non–biologists,
Attractive/ aggressive
PROPOSED STRATEGY
TO REAP A HARVEST OF
BIOTECHNOLOGY
BIO-FORUM 2006
MARCH 13-15, 2006
The Centres for Molecular Biology, University of the Punjab,
Lahore, Pakistan and PISELLI CONSULTING S.L. Barcelona,
Spain, will jointly organize “Bioforum 2006” in Lahore,
Pakistan from March 13-16, 2006. This will be the first
partnering conference held in Pakistan and will bring together
industry and academia from Pakistan, neighboring India, and
Middle-Eastern countries.
Participants
include professionals,
company
regulatory affairs and project management.
officials,
The forum will also include
Concurrent Workshops
information please visit
and
Plenary
Lecture
www.cemb.edu.pk/Bioforum2006
For
more
VENUE
National Centre of Excellence in Molecular Biology
University of the Punjab
87-West Canal Bank Road, Thokar Niaz Baig
LAHORE-53700, Pakistan
Tel: 042-5421235
Fax: 042-542-1316
Email: [email protected]
PROGRAMME
www.cemb.edu.pk/Bioforum2006
PLENARY LECTURES
GLOBALIZATION OF R&D EFFORTS THROUGH COLLABORATIVE ENDEAVOURS.
OUTSOURCING AS A MEANS TO ACTIVATE GLOBALIZATION
OPTIMIZATION OF RETURNS FROM UNIVERSITY RESEARCH – TECHNICAL & LEGAL
MEASURES
ENFORCEMENT OF PATENTS IN PAKISTAN
FUNDING FOR PAKISTAN’S RESEARCH & DEVELOPMENT IN LIFE SCIENCES
REGULATORY ISSUES
An Overview of cGMP Requirements by USFDA / European FDA (legal principles and
implementation tools)
 Introduction to validation
 Regulatory/ user requirements
 Good engineering practices
 Protocols
cGMP APPLICATIONS
 Concepts and regulations
 Contamination and cross contamination issues/ drug safety
 Design of GMP bio-containment facilities for pharmaceutical and vaccine production
 Risk and impact assessment
 Impact on operation
CONCURRENT WORKSHOPS
I:
II:
III:
IV:
V:
food
Vaccines (Hepatitis B &C)
siRNA Technology as a new Therapeutic Tool
Stem Cells & Regenerative Medicine
Bioethical issues in Research & Clinical Trials
Detection of chemical, biological and GMO’s toxic materials in the environment and
chain
REGISTRATION OF PHARMACEUTICALS IN PAKISTAN
CLINICAL TRIALS
APPROVAL PROCESS OF PHARMACEUTICALS
PARTNERING SESSIONS AMONG UNIVERSITY SCIENTISTS AND
ENTREPRENEURS
 Agriculture
 Health
 Industry
THE CENTRE FOR MOLECULAR BIOLOGY
COORDIALLY INVITES YOU
TO PARTICIPATE IN THE BIOFORUM
EXHIBITION
MARCH 13-15, 2006
LOCAL HOSPITALITY WILL BE
PROVIDED BY THE ORGANIZORS
IF YOU WISH TO PARTICIPATE IN THE EXHIBITION
please complete the following information
for your product/ process
and send it to [email protected]; [email protected]
THANK
YOU