Transcript Retinoblastoma - Sacred Heart Academy

Retinoblastoma
Retinoblastoma is a rare form of eye cancer that
develops in the retina usually before the age 5
• In most cases the disease is caused by a mutation in the
gene RB1
• RB1- regulates cell growth
• When mutated tumors form
• 2 types of the mutation
• Deletion of the segment of chromosome 13 that has RB1
• Deletion of several genes
• Slows growth
• Intellectual problems
• Distinct facial features
• Germinal Retinoblastoma
• Higher risk to other cancers
• Brain(pinealoma), bone(osteosarcoma), soft tissue, and
skin(melanoma)
Cause
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Most commonly only affects one eye
1/3 get it in both
When one eye is effected-> hard to tell if germinal or not
40% in germinal-> inherited
• Autosomal dominant
• No sex bias
• one copy-> affected
• 2 eyes affected
• 60% not germinal-> not inherited
• One eye is affected
Inheritance
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1st sign- white in the pupil->”cat’s eye reflex”
Crossed eyes
Eyes don’t point in same direction
Eye pain
Redness/irritation
Blindness/poor vision
Symptoms
• 3 main ways Retinoblastoma is diagnosed
• Eye exams-> doctor too see what is causing the symptoms
• Imaging Tests-> doctor see if the disease has affected other
areas near the eye
• Consulting with different doctors-> oncologist
• cancer doctor
Diagnosis
• If detected early-> curable
• If not treated fast-> spreads-> life threatening
• Treatments include:
• Chemotherapy, laser therapy, radiation therapy
• Cold, Heat Treatments
• Surgery
• Removal of affect eye-> implant ->fake eye
Treatment
• Retinoblastoma
• A cancer of the eye
• Can be inherited
• Autosomal dominant
• Least common
• Not inherited
• Most common
• Can be in one eye or both eyes
• Needs to be detected early or it will be life threatening
• Can be treated through therapies, treatments, or surgery
Summary!
• http://ghr.nlm.nih.gov/condition/retinoblastoma
• http://www.mayoclinic.com/health/retinoblastoma/DS007
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• http://www.cancer.gov/cancertopics/types/retinoblastoma
• http://www.cancer.org/cancer/retinoblastoma/
• http://emedicine.medscape.com/article/1222849-overview
• http://www.hinsdale86.org/staff/kgabric/Disease09/Retin
oblastoma/
• http://ghr.nlm.nih.gov/gene/RB1
Works Cited