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HPV & Cervical Cancer
Frequently Asked Questions
HPV & Cervical Cancer Prevention
2009 International Toolkit
What is Cervical Cancer?
2
Cervical cancer is cancer of the
cervix, the part of the uterus or
womb that opens to the vagina.
Before widespread use of the Pap
test in the 1950s, cervical cancer
was the leading cause of cancer
death in American women.
Today in the U.S., the Pap test has
helped reduce cervical cancer death
rates by 74%.
Burden of Disease
3
Worldwide, cervical cancer affects 490,000 women and
causes more than 270,000 deaths per year.
80% of women dying from cervical cancer reside in
developing countries.
In the U.S., cervical cancer affects more than 11,000
women and causes approximately 4,000 deaths per year.
Barriers to Prevention
4
Cervical cancer disproportionately affects minority women
and those with lower income.
According to a National Cancer Institute survey of 3,000
women:
• Only 40% had heard of HPV.
• Less than 50% knew of HPV’s link to cervical cancer.
Many developing countries lack the access to and availability of
vaccines and screening technologies.
What causes cervical cancer?
5
A virus – the human papillomavirus, or HPV – is the primary
cause of cervical cancer.
HPV is a highly common sexually transmitted virus that
usually goes away by itself without symptoms or treatment.
50% to 80% of all men and women will have HPV at some
point in their lives.
What causes cervical cancer?
(Continued)
6
Most infections will not develop into cervical cancer, are only temporary
and will go away without treatment.
Two types of HPV:
• Low-risk – can cause genital warts.
• High-risk – can lead to cancer. If the infection persists, pre-cancerous
cells may form.
Cervical cancer may develop if:
• A woman’s immune system does not destroy the infection and precancerous cells.
• The pre-cancerous cells are not found and treated.
What are the risk factors
For HPV & Cervical cancer?
7
Since cervical cancer is caused by HPV, any woman who is sexually
active can be diagnosed with cervical cancer.
HPV transmission occurs with skin-to-skin contact. Condoms may
reduce the risk of HPV, but they do not fully protect against the virus.
Other contributing risk factors for HPV and cervical cancer include:
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Immune suppression or HIV infection
Cigarette smoking
Sexual activity beginning at an early age
Multiple sex partners
Chlamydia infection
Diet low in fruits and vegetables
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Overweight or obese
Oral contraceptives
Multiple pregnancies
Low socioeconomic status
Family history of cervical cancer
Does HPV have symptoms?
8
In most cases HPV does not symptoms.
HPV test – the only way to detect a high-risk HPV infection.
Signs of an HPV infection may appear weeks, months, or years
after the infection.
Cervical cell changes – that result from an HPV infection and
may lead to cancer – can only be detected by a Pap test. These
changes do not have symptoms.
Can hpv be treated?
9
There is no treatment for HPV.
There are treatments for cervical cell changes that HPV can
cause.
Women with such changes should discuss treatment options
with their doctor.
What are the symptoms of
Cervical cancer?
10
Cervical cancer or early cervical pre-cancers often have no signs
or symptoms. Early symptoms may include:
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Any unusual discharge from the vagina
Blood spots or light bleeding when you're not having your period
Bleeding after menopause
Bleeding or pain during sex
The symptoms do not necessarily mean a diagnosis of cervical
cancer – these may occur for other reasons.
Women with any of these symptoms should contact their doctor
immediately.
Can cervical cancer be treated?
11
Cervical cancer can be treated with:
• Surgery
• Radiation and/or
• Chemotherapy
Women diagnosed with cervical cancer should discuss
treatment options with their doctor.
A few things to remember
12
50% to 80% of all men and women will have HPV at some point
in their lives.
Most infections will not develop into cervical cancer, are only
temporary and will go away without treatment.
Cervical cancer:
• Largely preventable – regular screening, changing or avoiding certain risk
factors, and vaccinations are essential.
• Caused by a common virus – the human papillomavirus, or HPV.
• Does not usually have symptoms.
References
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American Cancer Society. Cancer Facts and Figures 2009. Atlanta, GA: American Cancer Society; 2009.
American Cancer Society. Cervical Cancer. www.cancer.org/docroot/CRI/CRI_2_1x.asp?dt=8.
Centers for Disease Control and Prevention. www.cdc.gov/std/HPV/STDFact-HPV.htm#common.
Food and Drug Administration. Gardasil (human papillomavirus quadrivalent [types 6, 11, 16, 18] vaccine,
recombinant). www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2006/ucm108666.htm.
Food and Drug Administration. HPV (human papillomavirus).
www.fda.gov/ForConsumers/ByAudience/ForWomen/ucm118530.htm.
GlaxoSmithKline. www.gsk.com/media/pressreleases/2009/2009_pressrelease_10051.htm.
National Cervical Cancer Public Education Campaign. www.cervicalcancercampaign.org.
Naucler P, Ryd W, Törnberg S, Strand A, Wadell G, Elfgren K, et al. Human papillomavirus and
Papanicolaou tests to screen for cervical cancer. New England Journal Medicine 2007; 357:1589-97.
Nobelförsamlingen. The discoveries of human papillomaviruses that cause cervical cancer and of human
immunodeficiency virus. nobelprize.org/nobel_prizes/medicine/laureates/2008/adv.pdf.
World Health Organization. Cervical cancer, human papillomavirus (HPV), and HPV vaccines – Key points for
policy-makers and health professional. Geneva, Switzerland: WHO; 2007.
www.who.int/hpvcentre/publications/en/index.html.
HPV & Cervical Cancer
Frequently Asked Questions
HPV & Cervical Cancer Prevention
2009 International Toolkit