Transcript Department of Defense Long

Michael Birrer, PI, Director, Gynecologic Medical Oncology, MGH
Lari Wenzel, Co-PI, Prof. of Medicine, University of California, Irvine
[email protected]
Finding the Key to Long-Term Survival for All Women
23,000 women in the USA each year are diagnosed with
Ovarian Cancer
80% have an advanced stage cancer (Stage III or IV)
16,000 women in USA die of Ovarian Cancer each year
But 10% Do Survive Long Term !
Finding the Key to Long-Term Survival for All Women
Who Are We?
Finding the Key to Long-Term Survival for All Women
• What is different about long-term (10+ years) survivors?
• Is it something about the patient or the tumor or both?
• What are the long-term consequences of the diagnosis and
treatment of ovarian cancer?
Finding the Key to Long-Term Survival for All Women
Goals
PROs
QOL
Finding the Key to Long-Term Survival for All Women
 Identify Stage 3 or 4 Ovarian Cancer Long-Term Survivors
 Collect Tissues and Characterize
1. Molecular markers (genetic, biochemical, immunology)
2. Patient Quality of Life
 Identify a Link Between 1 and 2
 Establish Clinical Tools and Targeted Therapies
Finding the Key to Long-Term Survival for All Women
Consortium Structure
Scientific Advisory Board
Chair: Phil DiSaia
PATIENTS
Advocate Advisory Board
Chair: Mary Scroggins
Coordinating Center: MGH
PI: Michael J. Birrer
Co-PI: Lari Wenzel, Ph.D.
GOG Clinical Trials
39 Institutions
Scientific
Committee
Research
Sites
GOG Tissue Bank
39 Institutions
Genomic, Biologic, Psychosocial
Data Collection
Clinical Conclusions: Tools and Targets
The Gynecology Oncology Group
Tissue Repository
Patients Database
50 Principal Centers and 187 Participating Hospitals
Multi-Modality Group with Over 2100 Participants
GOG Clinical Trials Brought ALL the Major Improvements
in the Management of Ovarian Cancer
Finding the Key to Long-Term Survival for All Women
Ensures the project remains patient- and goalfocused, scientifically sound, and clinically relevant
Finding the Key to Long-Term Survival for All Women
Identification of Long-Term Survivors (10+ years) with
Advanced Stage Ovarian Cancer (Stage III and IV only)
Paraffin-Embedded Tumor Specimen from
ANY Biopsy or Surgery
“Quality of Life”, Toxicity and Medical Treatment Reports
Finding the Key to Long-Term Survival for All Women
Please Contact
The Long-Term Survivors Group:
[email protected]
Finding the Key to Long-Term Survival for All Women