Transcript Strata Oncology - Di..

Cancer
1.6M new cases
600K deaths
12.7M new cases
7.6M deaths
Cancer is a disease of
DNA mutations
Frequency
100’s of different gene mutations cause cancer
ALK
Mutated cancer genes
Matthew
• Aug 2011: Diagnosed with stage IV lung cancer
• Sept 2, 2011: Critical condition - collapsed lungs,
respiratory failure, pulmonary embolism
“I was dying”
• Sept 10, 2011: ALK test, first dose of crizotinib (Pfizer)
• Sept 21, 2011: discharged, no signs of cancer
• May 2012: cancer relapsed, ceritinib (Novartis)
• June 2012: Quick, dramatic improvements
• January 2013: cancer progressed again, new
chemotherapy regimen
• September 2013: PhD student, Cleveland Clinic
studying cancer mutations
Matthew
• June 2014: Got married, still on chemotherapy
• July 2015: New clinical trial, back in remission
“Unlike most people my age, I am not planning things
too far into the future. I usually only look about three to
six months ahead,” he says. “I have learned to really
‘stop to smell the roses’, as cliché as that sounds. I have
found it is so important to take things day by day and
appreciate all the little things in life.”
crizotinib
20 months
ceritinib
28 months
?
Frequency
Dozens of new precision medicines coming
Mutated cancer genes
Approved Drugs
Investigational Drugs
ROS1
NTRK1-3
MAP2K1
MAPK1
Catch-22
$$
Reimbursement
X
Genetic Testing
X
X
Precision Medicine Trials
Strata Trial
1. Sequence 100,000 cancer patients & match to trials
2. Accelerate 10 new drug approvals in 5 years
1. DNA sequencing
2. Big data
3. Precision oncology network
11/18
S trata Onco l o gy
12/18
S trata Onco l o gy
100 million wells / chip
100 bases / well / 3 hour run
= 10 billion bases / run
1 cancer genome = 3 billion bases
One 3X cancer genome / run
- OR Target 100 informative genes only
= 100,000 bases
With barcoding & multiplexing
100 1,000X cancer genomes / run
Alignment & Variant Calling
100 – 200 patient samples / day
10 – 20 billion bases / day
25 – 50,000 patient samples / year
2 – 4 trillion bases / year
1,000+ trial matches / year
Regional hospital
Pharma trials
Cancer Centers
Strata Oncology
Tumor
sample
Cancer patient
DNA sequencing + Big data + Precision oncology network
= Broadened access + Better outcomes