Transcript Differential genetic interactions of yeast stress

Differential genetic interactions of yeast stress response
MAPK pathways
by Humberto Martin, Michael Shales, Pablo Fernandez‐Piñar, Ping Wei, Maria
Molina, Dorothea Fiedler, Kevan M Shokat, Pedro Beltrao, Wendell Lim, and Nevan
J Krogan
Mol Syst Biol
Volume 11(4):800
April 17, 2015
©2015 by European Molecular Biology Organization
A differential epistatic interaction map (dE‐MAP) of Saccharomyces cerevisiae MAPK stress
pathways A total of 49 deletion query genes related to MAPK signalling (i.e. kinases,
phosphatases, transcription factors, adaptors) were crossed against a deletion...
Humberto Martin et al. Mol Syst Biol 2015;11:800
©2015 by European Molecular Biology Organization
Differential genetic interactions are extensive and specific and recapitulate previously known
functional associations Scatterplot of the genetic interaction S‐scores in the presence and
absence of zymolyase.
Humberto Martin et al. Mol Syst Biol 2015;11:800
©2015 by European Molecular Biology Organization
Putative gene–complex associations highlight novel roles for membrane trafficking and the
COMPASS complexes in modulating the cell wall integrity pathway Condition‐specific
associations between the query genes and protein complexes were predicted based o...
Humberto Martin et al. Mol Syst Biol 2015;11:800
©2015 by European Molecular Biology Organization
Correlation of genetic profiles under different conditions provides insights into
condition‐dependent functional interactions AThe vector of genetic interaction S‐scores for each
query gene was used to calculate pair‐wise Pearson correlation coefficient...
Humberto Martin et al. Mol Syst Biol 2015;11:800
©2015 by European Molecular Biology Organization
Dissection of differential genetic interactions into post‐translational and transcriptional
regulatory components Representation of the HOG pathway and the fraction of SO‐dependent
genetic interactions explained by different types of query genes: sensors...
Humberto Martin et al. Mol Syst Biol 2015;11:800
©2015 by European Molecular Biology Organization