Transcript Joey Barnett, Ph.D. Vice Chair, Department of Pharmacology

Pharmacology Training Programs
in the Future
Major Accomplishments in Pharmacology and
Impact of other disciplines.
(partly from ASPET’s “Significant events in Pharmacology”)
1978 - Discovery of G proteins - biochemistry
1981-1983 - ANP - physiology/biochemistry
1988 - ANP receptor Guanylyl Cyclase - biochem/mol. biology
1987 - Zidovudine effective against HIV - virology/immunology
Late 80’s to 90’s - Structures of G proteins (ras, Gi, Gs, G)
biochem/structural biol
1997 - structure of adenylyl cyclase - biochem/structural biol
2000 - structure of rhodopsin (GPCR) - biochem/structural biol
90’s - current - transgenics and knock outs - genetics/mol.
biol./physiol/pathology.
Systems
Pharmacogenomics Biology
Mathematical
Modeling
Molecular Biology
Biochemistry
Chemistry
Pharmacology
Immunology
Microbiology
Genetics
Cell Biology
Physiology
Structural Biology
Proteomics
Astrophysics
Pharmacology
Students/Postdocs
Other (writing
Patent law, etc)
Industry
Administration
Govt.
(CDC
NIH, etc.)
Science
(R&D)
Academia
Teaching
Needs on curriculum: How much do we teach?
What do we teach?
More Biochemistry? Proteomics?
Systems Biology/ Computational Biology (Mathematical
Modeling)? - Collaborations with biology/math depts.
- joint programs?
Small molecule screens? (interactions with industry)
Intellectual Property and Patenting? (ditto)
More genomics/genetics?
Structure based inhibitors/activators? Structural Biology?
Administration? Ph.D/MBA programs?
Enhance the translational side of research
Collaborations with Clinicians (co-mentors/committee members)
- insights into clinical trials
Collaborations/Partership with Industry (scholarships/fellowships)
Co-mentors in Industry?
Advantages: Learn hands-on the processes that contribute
to drug development - analyses of clinical trial data
Gain insights into the nuances of how Industry
works - from data books, proprietary rights, to research
priorities.
Make informed decisions about careers in industry.
Hurdles: Time away from primary lab
Delay in publications!
Commitment on part of industry? - investment?